Patents by Inventor Philip M. Carabateas
Philip M. Carabateas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5324737Abstract: 2-R.sub.2 -R.sub.4 -substitutea-3-R.sub.3 -CO-1-[(C-attached-N-heteryl)(Alk).sub.n ]-1H-indoles useful as analgesic, anti-rheumatic, anti-inflammatory or anti-glaucoma agents.Type: GrantFiled: September 26, 1991Date of Patent: June 28, 1994Assignee: Sterling Winthrop Inc.Inventors: Thomas E. D'Ambra, Edward R. Bacon, Malcolm R. Bell, Philip M. Carabateas, Michael A. Eissenstat, Virendra Kumar, John P. Mallamo, Susan J. Ward
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Patent number: 5068234Abstract: 2-R.sub.2 -R.sub.4 -substituted-3-R.sub.3 -CO-1-[(C-attached-N-herteryl)-(Alk).sub.n ]-1H-indoles useful as analgesic, anti-rheumatic, anti-inflammatory or anti-glaucoma agents.Type: GrantFiled: February 26, 1990Date of Patent: November 26, 1991Assignee: Sterling Drug Inc.Inventors: Thomas E. D'Ambra, Edward R. Bacon, Malcolm R. Bell, Philip M. Carabateas, Michael A. Eissenstat, Virendra Kumar, John P. Mallamo, Susan J. Ward
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Patent number: 4861791Abstract: Compounds of the formula ##STR1## wherein the substituents are as defined herein are useful as antiviral agents, in particular against picornaviruses.Type: GrantFiled: December 3, 1987Date of Patent: August 29, 1989Assignee: Sterling Drug Inc.Inventors: Guy D. Diana, Philip M. Carabateas
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Patent number: 4857539Abstract: Compounds of the formula ##STR1## wherein: Y is an alkylene bridge of 3-9 carbon atoms;Z is N or HC;R is hydrogen or lower-alkyl of 1-5 carbon atoms, with the proviso that when Z is N, R is lower-alkyl;R.sub.1 and R.sub.2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarbonyl or trifluoromethyl; andHet is selected from specified heterocyclic groups,are useful and antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.Type: GrantFiled: June 16, 1987Date of Patent: August 15, 1989Assignee: Sterling Drug Inc.Inventors: Guy D. Diana, Philip M. Carabateas
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Patent number: 4431651Abstract: 3,4-Dihydro-3-R.sub.1 -4-R.sub.2 -5-Q-6-R-2(1H)-pyridinones (I), where R.sub.1 and R.sub.2 are each hydrogen or methyl, R is lower-alkyl, and Q is 4(or 3)-hydroxyphenyl, 4(or 3)-methoxyphenyl, 4(or 3)-pyridinyl or 4(or 3)-pyridinyl having one or two lower-alkyl substituents, or acid-addition salts thereof, and their preparation are shown. Also shown is the cardiotonic use of I where Q is 4(or 3)-hydroxyphenyl, 4(or 3)-pyridinyl or 4(or 3)-pyridinyl having one or two lower-alkyl substituents.Type: GrantFiled: November 18, 1982Date of Patent: February 14, 1984Assignee: Sterling Drug Inc.Inventors: George Y. Lesher, Baldev Singh, Philip M. Carabateas
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Patent number: 4268678Abstract: 4-(Arylaliphatic)isoxazoles, having antiviral activity, are prepared by reacting with hydroxylamine a diketone of the formula Ar-Y-CH(CO-R).sub.2, wherein Ar is substituted phenyl, Y is (CH.sub.2).sub.n or O(CH.sub.2).sub.n, and R is lower-alkyl.Type: GrantFiled: September 4, 1979Date of Patent: May 19, 1981Assignee: Sterling Drug Inc.Inventors: Guy D. Diana, Philip M. Carabateas
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Patent number: 4261928Abstract: 4-(Aryloxyalkyl)pyrazoles of the formula ##STR1## useful as antiviral agents, are prepared by reacting the corresponding diketones of the formula Ar--O--Alk--CH(COR')COR" with hydrazine or a substituted hydrazine H.sub.2 NNHR.Type: GrantFiled: October 24, 1979Date of Patent: April 14, 1981Assignee: Sterling Drug Inc.Inventors: Guy D. Diana, Philip M. Carabateas
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Patent number: 4234725Abstract: 4-(Aryloxyalkyl)pyrazoles of the formula ##STR1## useful as antiviral agents, are prepared by reacting the corresponding diketones of the formula Ar--O--Alk--CH(COR')COR" with hydrazine or a substituted hydrazine H.sub.2 NNHR.Type: GrantFiled: October 24, 1979Date of Patent: November 18, 1980Assignee: Sterling Drug Inc.Inventors: Guy D. Diana, Philip M. Carabateas
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Patent number: 4232161Abstract: 4-(Aryloxyalkyl)pyrazoles of the formula ##STR1## useful as antiviral agents, are prepared by reacting the corresponding diketones of the formula Ar-O-Alk-CH(COR')COR" with hydrazine or a substituted hydrazine H.sub.2 NNHR.Type: GrantFiled: October 24, 1979Date of Patent: November 4, 1980Assignee: Sterling Drug Inc.Inventors: Guy D. Diana, Philip M. Carabateas
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Patent number: 4209526Abstract: 4-(Aryloxyalkyl)pyrazoles of the formula ##STR1## useful as antiviral agents, are prepared by reacting the corresponding diketones of the formula Ar-O-Alk-CH(COR')COR" with hydrazine or a substituted hydrazine H.sub.2 NNHR.Type: GrantFiled: February 1, 1979Date of Patent: June 24, 1980Assignee: Sterling Drug Inc.Inventors: Guy D. Diana, Philip M. Carabateas
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Patent number: 4171365Abstract: 4-(Aryloxyalkyl)pyrazoles of the formula ##STR1## useful as antiviral agents, are prepared by reacting the corresponding diketones of the formula Ar--O--Alk--CH(COR')COR" with hydrazine or a substituted hydrazine H.sub.2 NNHR.Type: GrantFiled: August 5, 1977Date of Patent: October 16, 1979Assignee: Sterling Drug Inc.Inventors: Guy D. Diana, Philip M. Carabateas
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Patent number: 4055588Abstract: 4-(3-Nitrophenyl)pyridine, an intermediate useful in the preparation of 1-(lower-alkyl)-1,4-dihydro-4-oxo-7-(4-pyridyl)-3-quinolinecarboxylates, which are useful as antibacterial agents, is prepared by reacting 3-nitrobenzaldehyde with two molar equivalents of di-(lower-alkyl) oxalacetate (II) in the presence of a catalytic condensing agent, preferably piperidine and/or its acetate, to produce tetra-(lower-alkyl) 3-(3-nitrophenyl)-1,5-pentanedione-1,2,4,5-tetracarboxylate (III), reacting III with ammonia to produce tetra-(lower-alkyl) 1,4-dihydro-4-(3-nitrophenyl)-2,3,5,6-pyridinetetracarboxylate (IV), oxidizing IV to produce tetra-(lower-alkyl) 4-(3-nitrophenyl)-2,3,5,6-pyridinetetracarboxylate (V), hydrolyzing V to produce 4-(3-nitrophenyl)-2,3,5,6-pyridinetetracarboxylic acid (VI) and decarboxylating VI to produce 4-(3-nitrophenyl)pyridine (VI). Intermediates III, IV, V and VI are novel.Type: GrantFiled: August 18, 1976Date of Patent: October 25, 1977Assignee: Sterling Drug Inc.Inventors: Philip M. Carabateas, Gordon L. Williams
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Patent number: 4008239Abstract: 4-(3-Nitrophenylpyridine and intermediate useful in the preparation of 1-(lower-alkyl)-1,4-dihydro-4-oxo-7-(4-pyridyl)-3-quinolinecarboxylates, which are useful as antibacterial agents, is prepared by reacting 3-nitrobenzaldehyde with two molar equivalents of di-(lower-alkyl) oxalacetate (II) in the presence of a catalytic condensing agent, preferably piperidine and/or its acetate, to produce tetra-(lower-alkyl) 3-(3-nitrophenyl)-1,5-pentanedione-1,2,4,5-tetracarboxylate (III), reacting III with ammonia to produce tetra-(lower-alkyl) 1,4-dihydro-4-(3-nitrophenyl)-2,3,5,6-pyridinetetracarboxylate (IV), oxidizing IV to produce tetra-(lower-alkyl) 4-(3-nitrophenyl)-2,3,5,6-pyridinetetracarboxylate (V), hydrolyzing V to produce 4-(3-nitrophenyl)-2,3,5,6-pyridinetetracarboxylic acid (VI) and decarboxylating VI to produce 4-(3-nitrophenyl)pyridine (VI). Intermediates III, IV, V and VI are novel.Type: GrantFiled: February 20, 1976Date of Patent: February 15, 1977Assignee: Sterling Drug Inc.Inventors: Philip M. Carabateas, Gordon L. Williams
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Patent number: 3994903Abstract: 4-(3-NITROPHENYL)PYRIDINE, AN INTERMEDIATE USEFUL IN THE PREPARATION OF THE ANTIBACTERIALLY ACTIVE 1-ALKYL-1,4-DIHYDRO-4-OXO-7-(4-PYRIDYL)-3-QUINOLINECARBOXYLIC ACIDS, IS PREPARED BY REACTING 4-(4-DIMETHYLAMINOPHENYL)PYRIDINE (I) with a demethylating agent to yield 4-(4-aminophenyl)pyridine (II), reacting said 4-aminophenyl compound (II) with a lower-alkanoylating agent to yield 4-[4-(lower-alkanoylamino)-phenyl]pyridine (III), nitrating the 4-(lower-alkanoylamino)-phenyl derivative (III) to yield 4-[4-(lower-alkanoylamino)-3-nitrophenyl]pyridine (IV), hydrolyzing the 4-(lower-alkanoylamino)-3-nitrophenyl compound (IV) to yield 4-(4-amino-3-nitrophenyl)-pyridine (V), and removing the 4-amino group of V by diazotization and reaction of the diazonium salt with a deaminating reducing agent to produce said intermediate 4-(3-nitrophenyl)pyridine (VI). Intermediates IV and V are novel.Type: GrantFiled: February 25, 1974Date of Patent: November 30, 1976Assignee: Sterling Drug Inc.Inventors: Philip M. Carabateas, Ruth Pauline Brundage
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Patent number: 3970662Abstract: 4-(3-Nitrophenyl)pyridine, an intermediate useful in the preparation of 1-(lower-alkyl)-1,4-dihydro-4-oxo-7-(4-pyridyl)-3-quinolinecarboxylates, which are useful as anti-bacterial agents, is prepared by reacting 3-nitrobenzaldehyde with two molar equivalents of di-lower-alkyl) oxalacetate (II) in the presence of a catalytic condensing agent, preferably piperidine and/or its acetate, to produce tetra-(lower-alkyl) 3-(3-nitrophenyl)-1,5-pentanedione-1,2,4,5-tetracarboxylate (III), reacting III with ammonia to produce tetra-(lower-alkyl) 1,4-dihydro-4-(3-nitrophenyl)-2,3,5,6-pyridinetetracarboxylate (IV), oxidizing IV to produce tetra-(lower-alkyl) 4-(3-nitrophenyl)-2,3,5,6-pyridinetetracarboxylate (V), hydrolyzing V to produce 4-(3-nitrophenyl)-2,3,5,6-pyridinetetracarboxylic acid (VI) and decarboxylating VI to produce 4-(3-nitrophenyl)pyridine (VII). Intermediates III, IV, V and VI are novel.Type: GrantFiled: June 19, 1975Date of Patent: July 20, 1976Assignee: Sterling Drug Inc.Inventors: Philip M. Carabateas, Gordon L. Williams