Abstract: The one-handed computer interface device is a computer input device that allows the user to input a full range of computer commands using only one hand. The one-handed computer interface device includes a housing having opposed upper and lower surfaces and at least one side surface. The upper surface of the housing is divided into a plurality of finger regions, with each finger region being adapted for receiving one of the user's fingers. Similarly, a thumb region is further defined on the at least one side surface, with the thumb region being adapted for receiving the user's thumb. A plurality of sets of finger tip sensors and a set of thumb tip sensors are respectively positioned within each finger region and the thumb region. In use, actuation of one of the finger tip and thumb tip sensors generates a command signal corresponding to actuation of a computer key.