Patents by Inventor Philip M. Zakas

Philip M. Zakas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Factor VIII proteins having ancestral sequences, expression vectors, and uses related thereto
    Patent number: 11897938
    Abstract: This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising the proteins or vectors and related methods of inducing blood clotting.
    Type: Grant
    Filed: June 23, 2021
    Date of Patent: February 13, 2024
    Assignees: EMORY UNIVERSITY, GEORGIA TECH RESEARCH CORPORATION
    Inventors: H. Trent Spencer, Christopher B. Doering, Philip M. Zakas, Eric Gaucher
  • FACTOR VIII PROTEINS HAVING ANCESTRAL SEQUENCES, EXPRESSION VECTORS, AND USES RELATED THERETO
    Publication number: 20210388055
    Abstract: This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising the proteins or vectors and related methods of inducing blood clotting.
    Type: Application
    Filed: June 23, 2021
    Publication date: December 16, 2021
    Applicants: EMORY UNIVERSITY, GEORGIA TECH RESEARCH CORPORATION
    Inventors: H. Trent Spencer, Christopher B. Doering, Philip M. Zakas, Eric Gaucher
  • Factor VIII proteins having ancestral sequences, expression vectors, and uses related thereto
    Patent number: 11046750
    Abstract: This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising the proteins or vectors and related methods of inducing blood clotting.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: June 29, 2021
    Assignees: Emory University, Georgia Tech Research Corporation
    Inventors: H. Trent Spencer, Christopher B. Doering, Philip M. Zakas, Eric Gaucher
  • FACTOR VIII PROTEINS HAVING ANCESTRAL SEQUENCES, EXPRESSION VECTORS, AND USES RELATED THERETO
    Publication number: 20200277356
    Abstract: This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising the proteins or vectors and related methods of inducing blood clotting.
    Type: Application
    Filed: May 14, 2020
    Publication date: September 3, 2020
    Applicants: EMORY UNIVERSITY, GEORGIA TECH RESEARCH CORPORATION
    Inventors: H. Trent Spencer, Christopher B. Doering, Philip M. Zakas, Eric Gaucher
  • Factor VIII proteins having ancestral sequences, expression vectors, and uses related thereto
    Patent number: 10654910
    Abstract: This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising the proteins or vectors and related methods of inducing blood clotting.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: May 19, 2020
    Assignees: Emory University, Georgia Tech Research Corporation
    Inventors: H. Trent Spencer, Christopher Doering, Philip M. Zakas, Eric Gaucher
  • FACTOR VIII PROTEINS HAVING ANCESTRAL SEQUENCES, EXPRESSION VECTORS, AND USES RELATED THERETO
    Publication number: 20180009873
    Abstract: This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising the proteins or vectors and related methods of inducing blood clotting.
    Type: Application
    Filed: January 27, 2016
    Publication date: January 11, 2018
    Inventors: Trent H. Spencer, Christopher Doering, Philip M. Zakas, Eric Gaucher