Patents by Inventor Philip Ma

Philip Ma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Efficient ligand-mediated Ullmann coupling of anilines and azoles
    Patent number: 6541639
    Abstract: The present invention provides of method of preparing phenyl-substituted azoles. This method uses an efficient ligand-accelerated Ullmann coupling reaction of anilines with azoles. The coupling products are useful for preparing factor Xa inhibitors.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: April 1, 2003
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Jiacheng Zhou, Pasquale N. Confalone, Hui-Yin Li, Philip Ma, Lynette M. Oh, Lucius T. Rossano, Charles G. Clark, Chris Teleha
  • Efficient method for the conversion of nitriles to amidines
    Publication number: 20020165400
    Abstract: The present invention relates to processes for the conversion of nitrites to amidines in the preparation of compounds which are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex. The compounds described herein are potent thrombolytics and useful for the inhibition of platelet aggregation in the treatment of thromboembolic disorders.
    Type: Application
    Filed: April 25, 2002
    Publication date: November 7, 2002
    Inventors: Philip Ma, Pasquale N. Confalone, Hui-Yin Li
  • Enantioselective enzymatic aminolysis of a racemic 2-isoxazolylacetate alkyl ester
    Publication number: 20020160465
    Abstract: The present invention relates to a process for the enantioselective enzymatic aminolysis of racemic 2-[3-(4-cyanophenyl)-4,5-dihydro-5-isoxazolyl]acetate ((R/S)-I) by methyl N&agr;-Boc-L-&agr;,&bgr;-diaminoproprionate .p-toluenesulfonic acid. More specifically, this invention pertains to a process for the enantioselective enzymatic aminolysis of racemic isobutyl 2-[3-(4-cyanophenyl)-4,5-dihydro-5-isoxazolyl]-acetate by methyl N&agr;-Boc-L-&agr;,&bgr;-diaminoproprionate .p-toluene sulfonic acid to produce (R)-methyl-3-[[[3-(4-cyanophenyl)-4,5-dihydro-5-isoxazolyl]acetyl]amino]-N-(butoxycarbonyl)-L-alanine, an intermediate in the preparation of roxifiban, an isoxazoline-based platelet glycoprotein IIb/IIIa antagonist which has activity as an antithrombotic agent.
    Type: Application
    Filed: October 25, 2001
    Publication date: October 31, 2002
    Inventors: Robert DiCosimo, Philip Ma, Jaan A. Pesti
  • Synthesis of 1,3,5-trisubstituted pyrazoles
    Patent number: 6465656
    Abstract: A novel process for making 1,3,5-trisubstituted pyrazoles of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibitors.
    Type: Grant
    Filed: December 3, 2001
    Date of Patent: October 15, 2002
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Jiacheng Zhou, Lynette May Oh, Pasquale N. Confalone, Hui-Yin Li, Philip Ma
  • Efficient ligand-mediated ullmann coupling of anilnies and azoles
    Publication number: 20020099225
    Abstract: The present invention provides of method of preparing phenyl-substituted azoles. This method uses an efficient ligand-accelerated Ullmann coupling reaction of anilines with azoles. The coupling products are useful for preparing factor Xa inhibitors.
    Type: Application
    Filed: July 25, 2001
    Publication date: July 25, 2002
    Inventors: Jiacheng Zhou, Pasquale N. Confalone, Hui-Yin Li, Philip Ma, Lynette M. Oh, Lucius T. Rossano, Charles G. Clark, Chris Teleha
  • Efficient method for the conversion of nitriles to amidines
    Patent number: 6399784
    Abstract: The present invention relates to processes for the conversion of nitrites to amidines in the preparation of compounds which are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex. The compounds described herein are potent thrombolytics and useful for the inhibition of platelet aggregation in the treatment of thromboembolic disorders.
    Type: Grant
    Filed: January 10, 2001
    Date of Patent: June 4, 2002
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Philip Ma, Pasquale N. Confalone, Hui-Yin Li
  • Synthesis of 1,3,5-trisubstituted pyrazoles
    Publication number: 20020055641
    Abstract: A novel process for making 1,3,5-trisubstituted pyrazoles of the type shown below from appropriate phenyl hydrazines is described.
    Type: Application
    Filed: December 3, 2001
    Publication date: May 9, 2002
    Inventors: Jiacheng Zhou, Lynette May Oh, Pasquale N. Confalone, Hui-Yin Li, Philip Ma
  • Synthesis of 1,3,5-trisubstituted pyrazoles
    Patent number: 6329527
    Abstract: A novel process for making 1,3,5-trisubstituted pyrazoles of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibitors.
    Type: Grant
    Filed: October 10, 2000
    Date of Patent: December 11, 2001
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Jiacheng Zhou, Lynette May Oh, Pasquale N. Confalone, Hui-yin Li, Philip Ma
  • Crystalline roxifiban
    Patent number: 6306886
    Abstract: The potent platelet glycoprotein IIb/IIIa antagonist, roxifiban, is produced in crystalline form. Crystalline roxifiban exists in two polymorphic forms, designated Form 1 and Form 2. These polymorphic forms are characterized by x-ray powder diffraction and solid-state carbon NMR. Pharmaceutical compositions and methods for the treatment or prevention of diseases mediated by platelet aggregation are described.
    Type: Grant
    Filed: June 15, 1998
    Date of Patent: October 23, 2001
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Michael Blaise Maurin, Philip Ma, David John Meloni, Jaan A. Pesti, Lucius Thomas Rossano, Randall K. Ward, Jianguo Yin, Lin Hua Zhang, Goss S. Kauffman
  • Efficient method for the conversion of nitriles to amidines
    Publication number: 20010008886
    Abstract: The present invention relates to processes for the conversion of nitrites to amidines in the preparation of compounds which are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex. The compounds described herein are potent thrombolytics and useful for the inhibition of platelet aggregation in the treatment of thromboembolic disorders.
    Type: Application
    Filed: January 10, 2001
    Publication date: July 19, 2001
    Inventors: Philip Ma, Pasquale N. Confalone, Hui-Yin Li
  • Efficient method for the conversion of nitriles to amidines and species thereof
    Patent number: 6245914
    Abstract: The present invention relates to processes for the conversion of nitrites to amidines in the preparation of compounds which are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex. The compounds described herein are potent thrombolytics and useful for the inhibition of platelet aggregation in the treatment of thromboembolic disorders.
    Type: Grant
    Filed: July 1, 1999
    Date of Patent: June 12, 2001
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Philip Ma, Pasquale N. Confalone, Hui-Yin Li
  • Convergent synthesis of .alpha.-aryl-.beta.-ketonitriles
    Patent number: 6107508
    Abstract: The present invention relates to processes for the production of .alpha.-aryl-.beta.-ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.
    Type: Grant
    Filed: March 31, 1999
    Date of Patent: August 22, 2000
    Assignee: Dupont Pharmaceuticals Company
    Inventors: Jiacheng Zhou, Lynette May Oh, Philip Ma
  • Method for preparing .alpha.-chloroboronic acids from mannitol
    Patent number: 5973185
    Abstract: A novel process for making compounds of Formula I, ##STR1## wherein X is a leaving group selected from the group Br, Cl, TsO, MsO, and TfO and R is a 1,2-diol, from a compound of Formula II: ##STR2## is described.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: October 26, 1999
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Philip Ma, Biao Jiang
  • Efficient method for the conversion of nitriles to amidines
    Patent number: 5962693
    Abstract: The present invention relates to processes for the conversion of nitrites to amidines in the preparation of compounds which are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex. The compounds described herein are potent thrombolytics and useful for the inhibition of platelet aggregation in the treatment of thromboembolic disorders.
    Type: Grant
    Filed: October 5, 1998
    Date of Patent: October 5, 1999
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Philip Ma, Pasquale N. Confalone, Hui-Yin Li
  • Toy vehicle
    Patent number: D445465
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: July 24, 2001
    Assignee: Goldlok Toys Manufactory Co., Ltd.
    Inventor: Philip Ma
  • Toy vehicle
    Patent number: D445466
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: July 24, 2001
    Assignee: Goldlok Toys Manufactory Co., Ltd.
    Inventor: Philip Ma
  • Toy aeroplane
    Patent number: D449658
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: October 23, 2001
    Assignee: Goldlok Toys Manufactory Co., Ltd.
    Inventor: Philip Ma
  • Toy boat
    Patent number: D455464
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: April 9, 2002
    Assignee: Goldlok Toys Manufactory Co. Ltd.
    Inventor: Philip Ma
  • Packaging box
    Patent number: D455651
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: April 16, 2002
    Assignee: Goldlok Toys Manufactory Co., Ltd.
    Inventor: Philip Ma
  • Packaging box
    Patent number: D461124
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: August 6, 2002
    Assignee: Goldlok Toys Manufactory Co., Ltd.
    Inventor: Philip Ma