Patents by Inventor Philip Maria Timmerman

Philip Maria Timmerman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intravenous Drug Administration and Blood Sampling Model in the Awake Rat
    Publication number: 20070259435
    Abstract: There is a continuing need for increased throughput in the examination of new chemical entities (NCEs) in terms of the pharmacokinetic (PK) parameters. The aim was to validate a new study method which allows a higher throughput, the examination of inter-animal variability and a reduction in the numbers of animals needed for routine bioavailability studies of NCEs in awake rats. The design uses a new method for intravenous (iv) administration via the saphenous vein in combination with serial blood sampling via the tail vein. The multiple sampling method was compared with single sampling (decapitation) and the effect on haematocrit (Hct) levels was studied. Direct injection in the saphenous vein was compared to iv administration using an indwelling jugular catheter. Using structural different CE's, it was shown that a combination of direct injection via the saphenous vein and multiple sampling from the tail vein produces comparable plasma concentrations and subsequent PK results to the comparator methods.
    Type: Application
    Filed: May 24, 2005
    Publication date: November 8, 2007
    Applicant: Janssen Pharmaceutica N.V.
    Inventors: Claire Mackie, Marc Jozef Haseldonckx, Saskia Blokland, Koen Wuyts, Petra Gysemberg, Iris Juliana Verhoeven, Philip Maria Timmerman, Maria Johanna Nijsen
  • Morpholinyl containing benzimidazoles as inhibitors of respiratory syncytial virus replication
    Publication number: 20070043022
    Abstract: The present invention concerns morpholinyl containing benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula a prodrug, N-oxide, addition salt, quaternary amine, metal complex or stereochemically isomeric form thereof wherein G is a direct bond or optionally substituted C1-10alkanediyl; R1 is Ar1 or a monocyclic or bicyclic heterocycle Q is R7, pyrrolidinyl substituted with R7, piperidinyl substituted with R7 or homopiperidinyl substituted with R7; one of R2a and R3a is selected from halo, optionally mono- or polysubstituted C1-6alkyl, optionally mono- or polysubstituted C2-6alkenyl, nitro, hydroxy, Ar2, N(R4aR4b) N(R4aR4b)sulfonyl, N(R4aR4b)carbonyl, C1-6alkyloxy, Ar2oxy, Ar2C1-6alkyloxy, carboxyl, C1-6alkyloxycarbonyl, or —C(=Z)Ar2; and the other one of R2a and R3a is hydrogen; in case R2a is different from hydrogen then R2b is hydrogen, C1-6alkyl or halogen and R3b is hydrogen; in case R3a is different from hydrogen then R3b is hydrogen,
    Type: Application
    Filed: December 20, 2004
    Publication date: February 22, 2007
    Inventors: Jean-Francois Bonfanti, Koenraad Andries, Jerome Fortin, Phillippe Muller, Frederic Doublet, Christophe Meyer, Rudy Willebrords, Tom Gevers, Philip Maria Timmerman