Abstract: The current invention concerns a fluid microscope system for analyzing and/or monitoring the contents of one or more fluid-based reactors or canalizations such as bio-reactors, micro-reactors, brewing reactors, water supply systems or sewer systems. The fluid microscope system includes a digital holographic microscope (DHM) with one or more electro-fluidic systems, capable of guiding fluid from the reactors to the DHM. The current invention also concerns an electro-fluidic system for such a fluid microscope system having any or all of the elements mentioned above. Furthermore, the current invention encompasses a method for installing, replacing and removing such an electro-fluidic system in and from a fluid microscope system, and lastly, a method for monitoring and/or observing suspended objects in a fluid in a fluid-based reactor or canalization.

Abstract: A method for providing a viral infection status of at least one cell in a cell sample comprising receiving holographic information (304) of the cell sample obtained by digital holographic microscopy, and determining from the holographic information, the viral infection status (306) of the at least one cell.

Abstract: The current invention concerns a flow cytometric system and method for observing, analyzing and/or separating objects in a liquid sample, comprising a digital holographic microscope (DHM) and at least one fluidic system, whereby the DHM comprises illumination means, an interferometric system and digital recording means, whereby the fluidic system is capable of guiding said objects through an illumination beam of the illumination means of said DHM, whereby the fluidic system comprises a mechanism for inducing a liquid sample stream through the fluidic system, whereby preferably the fluidic system comprises a stream size controlling device for controlling the transverse dimensions of a liquid sample stream inside said fluidic system, preferably said stream size controlling device is capable of lining up the objects one-by-one or multiple objects at a time in said liquid sample stream.

Abstract: The current invention concerns a method for detecting cancerous cells and/or classifying cells in a cell sample comprising the following steps: providing a cell sample; obtaining holographic information from said cell sample by digital holographic microscopy (DHM); deriving at least one cellular parameter from said holographic information, and; classifying said cells of cells sample; characterized in that said classification occurs by appointing a Scoring Factor to said cells of cell sample, based on said cellular parameters. In a second aspect, a system for the detection of cancerous cells and/or classification of cells in a cell sample is provided, employing the method as disclosed in the invention. In a final aspect, a method for updating and/or improving a database comprising thresholds linked to holographic information and the database related thereof is equally disclosed.

Abstract: The current invention concerns a fluid microscope system for analyzing and/or monitoring the contents of one or more fluid-based reactors or canalizations such as bio-reactors, micro-reactors, brewing reactors, water supply systems or sewer systems comprising a digital holographic microscope (DHM) capable of obtaining phase information of a fluid sample and comprising illumination means and one or more fluidic systems connected to said reactors and to said DHM, capable of guiding fluid from said reactors to said DHM, whereby at least one fluidic system comprises one or more tubes which may come in direct contact with fluid from said reactor, characterized in that at least one tube comprises a part which is at least partially transparent for the illumination means of said DHM for obtaining holographic information of said fluid sample. The current invention also concerns a tube and a fluidic system for such a fluid microscope.

Abstract: The current invention concerns a method for detecting cancerous cells and/or classifying cells in a cell sample comprising the following steps: providing a cell sample; obtaining holographic information from said cell sample by digital holographic microscopy (DHM); deriving at least one cellular parameter from said holographic information, and; classifying said cells of cells sample; characterized in that said classification occurs by appointing a Scoring Factor to said cells of cell sample, based on said cellular parameters. In a second aspect, a system for the detection of cancerous cells and/or classification of cells in a cell sample is provided, employing the method as disclosed in the invention. In a final aspect, a method for updating and/or improving a database comprising thresholds linked to holographic information and the database related thereof is equally disclosed.

Abstract: The current invention concerns a fluid microscope system for analyzing and/or monitoring the contents of one or more fluid-based reactors or canalizations such as bio-reactors, micro-reactors, brewing reactors, water supply systems or sewer systems. The fluid microscope system includes a digital holographic microscope (DHM) with one or more electro-fluidic systems, capable of guiding fluid from the reactors to the DHM. The current invention also concerns an electro-fluidic system for such a fluid microscope system having any or all of the elements mentioned above. Furthermore, the current invention encompasses a method for installing, replacing and removing such an electro-fluidic system in and from a fluid microscope system, and lastly, a method for monitoring and/or observing suspended objects in a fluid in a fluid-based reactor or canalization.

Abstract: The current invention concerns a method for detecting cancerous cells and/or classifying cells in a cell sample comprising the following steps: providing a cell sample; obtaining holographic information from said cell sample by digital holographic microscopy (DHM); deriving at least one cellular parameter from said holographic information, and; classifying said cells of cells sample; characterized in that said classification occurs by appointing a Scoring Factor to said cells of cell sample, based on said cellular parameters. In a second aspect, a system for the detection of cancerous cells and/or classification of cells in a cell sample is provided, employing the method as disclosed in the invention. In a final aspect, a method for updating and/or improving a database comprising thresholds linked to holographic information and the database related thereof is equally disclosed.

Abstract: A vessel is for storing and monitoring a suspension of microscopic objects, which comprises a cap suitable for closing off the vessel. The cap includes a fluidics system, which includes an inlet and an outlet. The inlet and the outlet are arranged to be in an interior volume of the vessel when the cap is closing off the vessel. The cap also includes a measurement region for optical microscopy, which includes a sample region suitable for the suspension. The sample region is in fluid connection with the fluidics system. The cap also includes a pump suitable for inducing a flow in the fluidics system. A particular monitoring system and setup is for monitoring cells in a cell culture liquid.

Abstract: A vessel is for storing and monitoring a suspension of microscopic objects, which comprises a cap suitable for closing off the vessel. The cap includes a fluidics system, which includes an inlet and an outlet. The inlet and the outlet are arranged to be in an interior volume of the vessel when the cap is closing off the vessel. The cap also includes a measurement region for optical microscopy, which includes a sample region suitable for the suspension. The sample region is in fluid connection with the fluidics system. The cap also includes a pump suitable for inducing a flow in the fluidics system. A particular monitoring system and setup is for monitoring cells in a cell culture liquid.

Abstract: The current invention concerns a fluid microscope system for analyzing and/or monitoring the contents of one or more fluid-based reactors or canalizations such as bio-reactors, micro-reactors, brewing reactors, water supply systems or sewer systems comprising a digital holographic microscope (DHM) capable of obtaining phase information of a fluid sample and comprising illumination means and one or more fluidic systems connected to said reactors and to said DHM, capable of guiding fluid from said reactors to said DHM, whereby at least one fluidic system comprises one or more tubes which may come in direct contact with fluid from said reactor, characterized in that at least one tube comprises a part which is at least partially transparent for the illumination means of said DHM for obtaining holographic information of said fluid sample. The current invention also concerns a tube and a fluidic system for such a fluid microscope.

Abstract: The current invention concerns a flow cytometric system and method for observing, analyzing and/or separating objects in a liquid sample, comprising a digital holographic microscope (DHM) and at least one fluidic system, whereby the DHM comprises illumination means, an interferometric system and digital recording means, whereby the fluidic system is capable of guiding said objects through an illumination beam of the illumination means of said DHM, whereby the fluidic system comprises a mechanism for inducing a liquid sample stream through the fluidic system, whereby preferably the fluidic system comprises a stream size controlling device for controlling the transverse dimensions of a liquid sample stream inside said fluidic system, preferably said stream size controlling device is capable of lining up the objects one-by-one or multiple objects at a time in said liquid sample stream.

Abstract: The present invention discloses a method for analyzing a liquid cell sample, comprising the steps of: a) providing at least one liquid cell sample in a sample vial; b) obtaining data linked to the cells in the sample by performing differential digital holographic microscopy on said liquid cell sample in said sample vial. In a second aspect, the invention also provides for a system for analyzing a liquid cell sample, comprising (i) a differential digital holographic microscope comprising illumination means, a differential interferometer and a digital recording device connected to a processing device such as a computer; (ii) at least one exchangeable sample vial comprising a liquid cell (iii) a movable sample vial holder; characterized in that (iv) said sample vial holder is adapted to receive said sample vial; (v) said sample vial holder is adapted to position said sample vial such that the focal plane of the objective lens of said differential digital holographic microscope lies in the vial.

Abstract: The current invention concerns an object database comprising a set of object entries, which comprise object properties, whereby said object properties comprise obtained object properties, which comprise DHM-obtained object properties and preferably object identification properties, characterized in that said DHM-obtained object properties comprise properties about a sample comprising said objects, said information derived from information acquired by a digital holographic microscope (DHM) and whereby preferably said object identification properties comprise information about the objects which allow identification of the object between the object database and an database. The invention furthermore discloses an object database updating method and a computing system comprising an object database and object database updating method as disclosed in the current invention.

Abstract: The current invention concerns a method for detecting cancerous cells and/or classifying cells in a cell sample comprising the following steps: providing a cell sample; obtaining holographic information from said cell sample by digital holographic microscopy (DHM); deriving at least one cellular parameter from said holographic information, and; classifying said cells of cells sample; characterized in that said classification occurs by appointing a Scoring Factor to said cells of cell sample, based on said cellular parameters. In a second aspect, a system for the detection of cancerous cells and/or classification of cells in a cell sample is provided, employing the method as disclosed in the invention. In a final aspect, a method for updating and/or improving a database comprising thresholds linked to holographic information and the database related thereof is equally disclosed.

Abstract: A device for exchanging documents between two parties through a network comprises: an interface (13) arranged for receiving transmitter document data (16) coming from the network and including at least a transmitter identifier and an addressee identifier, a converter (15) capable of converting transmitter document data (16) into intermediate document data (18) on the basis of a transmitter model associated with the transmitter identifier of the transmitter document data (16), while keeping the transmitter identifier and the addressee identifier, a generator (20) capable of converting intermediate document data (18) on the one hand into addressee document data (22) on the basis of an addressee model associated with the addressee identifier of the intermediate document data (18), and on the other hand into archive document data (24), and a controller (14) arranged for calling the generator (20) with the resulting intermediate document data, and for storing the resulting archive document data for later access by