Abstract: An assembly for a body joint orthotic that generates a distraction force to the joint that can be synchronized with the flexion of said joint. The hinge may be polycentric or unicentric. For a polycentric hinge, the distraction can be generated by varying the distance between the axes of rotation of the two pivot points. For a unicentric hinge, the distraction can be generated by increasing the length of at least one of the arms that connects the strapping element which holds the orthotic to the limb or body part to the hinge. The synchronization of the amount of distraction to the angle of flexion may be achieved by purely mechanical mechanisms or involving a motor.

Abstract: A multi-axis rotational control hip orthosis that can stabilize and control forces around a hip joint and may be customized to a wearer's physical or medical needs.

Abstract: A metered dose inhaler comprising a metering valve, a canister, an actuator comprising an actuator nozzle, wherein the canister comprises a formulation, the formulation comprising greater than 70% by weight of propellant HFO-1234ze(E), and at least one active pharmaceutical ingredient dissolved in the formulation to form a solution, said active pharmaceutical ingredient preferably selected from beclomethasone, formoterol or tiotropium.

Abstract: An adjustable tensioning device capable of providing and holding high tensions needed for medical devices, prosthetics, and orthotics.

Abstract: The present invention is directed to a shaped soft goods article that is unitary non-woven material having at least one three-dimensional shape. The article includes a first region substantially formed of a first formula and a second region substantially formed of a second formula. Between the first and second regions, there is an intermingling region that includes at least some of the first formula and the second formula. The first and second formulas are both comprised of at least one type of natural or synthetic fibers and at least one of crosslinkers, natural and/or synthetic adhesives, biobased and/or synthetic thermoplastics, including nanocellulose, and/or latex; however, the first and second formulas differ in at least one characteristic. An intermingling region exists where the first region (and first formula) intermingle with the second region (and second formula) meet.

Abstract: The present invention discloses a shaped soft goods article that includes a first material, and second element at least partially embedded therein. The first material is a unitary non-woven material having at least one three-dimensional feature that is made from a slurry containing at least one type of natural or synthetic fibers and at least one of crosslinkers, natural and/or synthetic adhesives, biobased and/or synthetic thermoplastics, including nanocellulose, and/or latex. The second element can be functional or decorative.

Abstract: Novel mutant ESR1 molecules and uses are disclosed.

Abstract: A tension adjustment mechanism transforming the rotation of a dial into a change of volume of a worn-article, such as a prosthetic socket, to improve the fit of the worn-article.

Abstract: A method of making an optical article having a gradient tint and a gradient polarization. The method includes contacting one or more dye compositions including at least one of a dichroic dye, a photochromic-dichroic dye, or any combination thereof, with an optical element having a continuous coating including at least one alignment zone. At least a portion of the dye composition diffuses into the coating at a predetermined concentration gradient along at least a portion of the coating.

Abstract: A mycelium growth bed for growing a solid substrate-bound mycelium through which the mycelium composite is easily and readily removed. This is achieved through the use of a perforation layer embedded between the mycelium substrate and the mycelium composite so as to create a uniform structural weakness and thereby enhancing harvesting abilities of the ex-substrate mycelium via a greatly reduced and uniform tear strength. The perforation layer, through which the mycelium grows, allows for the gated and controlled extrusion of a matrix of colonial cells that may be easily and uniformly delaminated from the underlying mycelium substrate.

Abstract: A method, machine readable medium and system for RGBD semantic segmentation of video data includes determining semantic segmentation data and depth segmentation data for less than all classes for images of each frame of a first video, determining semantic segmentation data and depth segmentation data for images of each key frame of a second video including a synchronous combination of respective frames of the RGB video and the depth-aware video in parallel to the determination of the semantic segmentation data and the depth segmentation data for each frame of the first video, temporally and geometrically aligning respective frames of the first video and the second video, and predicting semantic segmentation data and depth segmentation data for images of a subsequent frame of the first video based on the determination of the semantic segmentation data and depth segmentation data for images of a key frame of the second video.

Abstract: A system and a method for controlling an electronic device embedded in a package of a consumer product are disclosed. In one aspect, the consumer product packaging includes a bottle for a beverage, a memory, a receiver and a circuit. The memory stores an action to be performed in response to an input. The receiver receives the input indicative of movement of the bottle. The circuit retrieves the action stored in memory upon receipt of the input and command an electronic communication module to perform the action at a particular time or in a particular sequence.

Abstract: An adjustable tensioning device capable of providing and holding high tensions needed for medical devices, prosthetics, and orthotics.

Abstract: An assembly for a body joint orthotic that generates a distraction force to the joint that can be synchronized with the flexion of said joint. The hinge may be polycentric or unicentric. For a polycentric hinge, the distraction can be generated by varying the distance between the axes of rotation of the two pivot points. For a unicentric hinge, the distraction can be generated by increasing the length of at least one of the arms that connects the strapping element which holds the orthotic to the limb or body part to the hinge. The synchronization of the amount of distraction to the angle of flexion may be achieved by purely mechanical mechanisms or involving a motor.

Abstract: An apparatus and methods for making for shoulder orthoses, which can control the position of the humeral head/arm relative to the shoulder joint by adjusting tension across the joint. The orthoses allows the user to modify the direction and magnitude of force applied while wearing the orthosis. The orthosis may contain cams or extensions to direct and amplify the force around the joint towards a specific range of motion. The orthoses can be made from digitally imaging joints and then partially or fully automating the design of orthosis.

Abstract: A multi-axis rotation control ankle brace, wherein the direction and magnitude of force can be controlled around three axes of the ankle joint through an adjustable tensioning apparatus. The device may be applied to address conditions such as chronic ankle instability, foot drop, or osteoarthritis by providing such forces around the joint as an external-muscle tendon system to improve function, reduce pain, or restore mobility of the user. While more are contemplated herein, five preferred embodiments are specifically disclosed in the current application. Three preferred embodiments comprise a proximal portion and a distal portion, wherein the proximal portion is anchored above the ankle joint and houses, in aspects, the adjustment mechanism. The proximal portion is connected to the distal portion by tensioning or compressive elements, through which threes can be controlled by the user via the adjustment mechanism.

Abstract: A system and a method for controlling an electronic device embedded in a package of a consumer product are disclosed. In one aspect, the consumer product packaging includes a bottle for a beverage, a memory, a receiver and a circuit. The memory stores an action to be performed in response to an input. The receiver receives the input indicative of movement of the bottle. The circuit retrieves the action stored in memory upon receipt of the input and command an electronic communication module to perform the action at a particular time or in a particular sequence.

Abstract: An adjustable tensioning device capable of providing and holding high tensions needed for medical devices, prosthetics, and orthotics.

Abstract: Method of price discovery includes: creating a bid design file as a set of specification variables, pricing variables, bid evaluation scenarios, and bid evaluation formulas; producing a scenario file as a set of observations; producing a specification variable matrix including the bid scenario for each observation and item; producing a bid template including producing a data structure as a bid template including the pricing variables, bid evaluation formulas, and the specification variable matrix; transmitting the bid template to the bidding suppliers; receiving completed bids; computing price savings attributable to each item across all bidding suppliers; producing a bid evaluation matrix including bid prices for each bidder for each item from the specification variables and computed price savings attributable to each item across all bidding suppliers; and displaying contents of the bid evaluation matrix to a buyer, as the price discovery for the plurality of bidding suppliers and items.

Abstract: A method of making an optical article having a gradient tint and a gradient polarization. The method includes providing an optical element including a coating having at least one alignment zone. A dye composition is contacted with the coating. The dye composition includes at least one of: a dichroic dye, a photochromic-dichroic dye, or a combination thereof to diffuse at least a portion of the dye composition into the coating at a predetermined concentration gradient along at least a portion of the coating to provide the gradient tint and the gradient polarization. A kit for making an optical article having a gradient tint and a gradient polarization. An optical article prepared from a method for making an optical article having a gradient tint and a gradient polarization.