Patents by Inventor Philip Morrissey
Philip Morrissey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8548219Abstract: Photometric and morphometric features derived from multi-mode imagery of cells in flow are used as a cell analyzer to determine if a marker corresponding to a cancer cell or precancerous cell is present in the population of cells imaged. An imaging system simultaneously acquires a plurality of images for each cell passing through the field of view of the imaging system. Acquiring a plurality of different images (i.e., bright field, dark field, and fluorescent images) facilitates the determination of different morphological and morphometric parameters. Simultaneously acquiring the plurality of images enables relatively large populations of cells to be rapidly imaged, so that relatively small numbers of cancer cells in a large population of cells can be detected. Initially, known cancer cells are imaged to enable a marker to be identified. Then, a sample that may include cancer cells is imaged to determine if the marker is present.Type: GrantFiled: February 14, 2012Date of Patent: October 1, 2013Assignee: Amnis CorporationInventors: William Ortyn, David Basiji, Luchuan Liang, Vidya Venkatachalam, Philip Morrissey
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Patent number: 8406498Abstract: Multimodal or multispectral images of cells comprising a population of cells are simultaneously collected. Photometric and/or morphometric image features identifiable in the images are used to identify differences between first and second populations of cells. The differences can include changes in a relative percentage of different cell types in each population, or a change in a first type of cell present in the first population of cells and the same type of cell in the second population of cells. The changes may be indicative of a disease state, indicative of a relative effectiveness of a therapy, or indicative of a health of the person from whom the cells populations were obtained.Type: GrantFiled: December 4, 2009Date of Patent: March 26, 2013Assignee: Amnis CorporationInventors: William Ortyn, David Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry
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Publication number: 20120148142Abstract: Photometric and morphometric features derived from multi-mode imagery of cells in flow are used as a cell analyzer to determine if a marker corresponding to a cancer cell or precancerous cell is present in the population of cells imaged. An imaging system simultaneously acquires a plurality of images for each cell passing through the field of view of the imaging system. Acquiring a plurality of different images (i.e., bright field, dark field, and fluorescent images) facilitates the determination of different morphological and morphometric parameters. Simultaneously acquiring the plurality of images enables relatively large populations of cells to be rapidly imaged, so that relatively small numbers of cancer cells in a large population of cells can be detected. Initially, known cancer cells are imaged to enable a marker to be identified. Then, a sample that may include cancer cells is imaged to determine if the marker is present.Type: ApplicationFiled: February 14, 2012Publication date: June 14, 2012Applicant: Amnis CorporationInventors: William Ortyn, David Basiji, Luchuan Liang, Vidya Venkatachalam, Philip Morrissey
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Patent number: 8131053Abstract: Photometric and morphometric features derived from multi-mode imagery of cells in flow are used as a cell analyzer to determine if a marker corresponding to a cancer cell or precancerous cell is present in the population of cells imaged. An imaging system simultaneously acquires a plurality of images for each cell passing through the field of view of the imaging system. Acquiring a plurality of different images (i.e., bright field, dark field, and fluorescent images) facilitates the determination of different morphological and morphometric parameters. Simultaneously acquiring the plurality of images enables relatively large populations of cells to be rapidly imaged, so that relatively small numbers of cancer cells in a large population of cells can be detected. Initially, known cancer cells are imaged to enable a marker to be identified. Then, a sample that may include cancer cells is imaged to determine if the marker is present.Type: GrantFiled: July 28, 2008Date of Patent: March 6, 2012Assignee: Amnis CorporationInventors: William Ortyn, David Basiji, Luchuan Liang, Vidya Venkatachalam, Philip Morrissey
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Patent number: 7925069Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.Type: GrantFiled: September 29, 2009Date of Patent: April 12, 2011Assignee: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry
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Publication number: 20100232675Abstract: Multimodal or multispectral images of cells comprising a population of cells are simultaneously collected. Photometric and/or morphometric image features identifiable in the images are used to identify differences between first and second populations of cells. The differences can include changes in a relative percentage of different cell types in each population, or a change in a first type of cell present in the first population of cells and the same type of cell in the second population of cells. The changes may be indicative of a disease state, indicative of a relative effectiveness of a therapy, or indicative of a health of the person from whom the cells populations were obtained.Type: ApplicationFiled: December 4, 2009Publication date: September 16, 2010Applicant: Amnis CorporationInventors: William Ortyn, David Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry
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Publication number: 20100021039Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.Type: ApplicationFiled: September 29, 2009Publication date: January 28, 2010Applicant: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry
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Patent number: 7634126Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.Type: GrantFiled: January 29, 2009Date of Patent: December 15, 2009Assignee: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry
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Patent number: 7634125Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.Type: GrantFiled: August 20, 2008Date of Patent: December 15, 2009Assignee: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry
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Publication number: 20090190822Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.Type: ApplicationFiled: January 29, 2009Publication date: July 30, 2009Applicant: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry
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Patent number: 7522758Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.Type: GrantFiled: February 1, 2006Date of Patent: April 21, 2009Assignee: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry
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Publication number: 20090003681Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.Type: ApplicationFiled: August 20, 2008Publication date: January 1, 2009Applicant: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry
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Publication number: 20080317325Abstract: Photometric and morphometric features derived from multi-mode imaged. An imaging system simultaneously acquires a plurality of images for each cell passing through the field of view of the imaging system. Acquiring a plurality of different images (i.e., bright field, dark field, and fluorescent images) facilitates the determination of different morphological and morphometric parameters. Simultaneously acquiring the plurality of images enables relatively large populations of cells to be rapidly imaged, so that relatively small numbers of cancer cells in a large population of cells can be detected. Initially, known cancer cells are imaged to enable a marker to be identified. Then, a sample that may include cancer cells is imaged to determine if the marker is present.Type: ApplicationFiled: July 28, 2008Publication date: December 25, 2008Applicant: Amnis CorporationInventors: William Ortyn, David Basiji, Luchuan Liang, Vidya Venkatachalam, Philip Morrissey
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Publication number: 20060257884Abstract: The present invention provides methods for preparing cells with highly condensed chromosomes, such as sperm, and methods for detecting and quantifying specific cellular target molecules in intact cells. Specifically, methods are provided for detecting chromosomes and chromosomal abnormalities, including aneuploidy, in intact cells using fluorescence in situ hybridization of cells in suspension, such as sperm cells.Type: ApplicationFiled: May 20, 2005Publication date: November 16, 2006Applicant: AMNIS CORPORATIONInventors: James Brawley, Philip Morrissey, Rosalynde Finch, David Basiji, Luchuan Liang
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Publication number: 20060204071Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.Type: ApplicationFiled: February 1, 2006Publication date: September 14, 2006Applicant: Amnis CorporationInventors: William Ortyn, David Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry