Patents by Inventor Philip N. Rather

Philip N. Rather has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of screening for anti-microbial utilizing aarC and compositions thereof
    Patent number: 6383745
    Abstract: The present invention provides an oligonucleotide (aarC) which encodes a novel bacterial polypeptide (AarC) that is essential for the viability of bacteria. The invention provides recombinant expression vectors comprising the nucleotide sequence encoding AarC, as well as host cells containing these expression vectors. Further provided herein are methods for screening bacteria which contain aarC or variants or homologs thereof. Also provided are methods for using the aarC oligonucleotide sequence to screen antimicrobials which target AarC activity in gram negative and gram positive bacteria. Additionally, the invention provides for the use of aarC in diagnostic assays which utilize the aarC oligonucleotide to hybridize with nucleic acid sequences encoding AarC as well as with AarC mRNA. The invention further describes monoclonal and polyclonal AarC antibodies and their use in diagnostic assays for the detection of bacteria which express AarC.
    Type: Grant
    Filed: October 13, 1998
    Date of Patent: May 7, 2002
    Assignee: Case Western Reserve University
    Inventor: Philip N. Rather
  • Methods for screening for antimicrobials utilizing AarC and compositions thereof
    Patent number: 5858367
    Abstract: The present invention provides an oligonucleotide (aarC) which encodes a novel bacterial polypeptide (AarC) that is essential for the viability of bacteria. The invention provides recombinant expression vectors comprising the nucleotide sequence encoding AarC, as well as host cells containing these expression vectors. Further provided herein are methods for screening bacteria which contain aarC or variants or homologs thereof. Also provided are methods for using the aarC oligonucleotide sequence to screen antimicrobials which target AarC activity in gram negative and gram positive bacteria. Additionally, the invention provides for the use of aarC in diagnostic assays which utilize the aarC oligonucleotide to hybridize with nucleic acid sequences encoding AarC as well as with AarC mRNA. The invention further describes monoclonal and polyclonal AarC antibodies and their use in diagnostic assays for the detection of bacteria which express AarC.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: January 12, 1999
    Assignee: Case Western Reserve University
    Inventor: Philip N. Rather