Abstract: A method for joining or reconstructing biological tissue comprises providing a solid filler material in the form of a preformed sheet, where the sheet comprises collagen, gelatin or a mixture thereof. The filler material is placed over tissue. Radiofrequency energy or optical energy is thereafter applied to the filler material in an amount sufficient to melt or denature the filler material.

Abstract: Biological materials are joined, repaired or fused by heating the material in proximity to a mechanical support. Preferably, the mechanical support comprises a patch or bridge structure. In the most preferred embodiment, the patch is formed from collagen having a thickness from between 2 to 30 mils, and most preferably from 2 to 15 mils thick. Preferably, the patch or support structure contains holes or interlock vias which permit the coagulum to form a mechanical bond therewith, whether preformed or generated by an electrical energy source during welding. The preferred method comprises the steps of: first, placing the patch in contact with the materials to be joined, supplying energy to the tissue in an amount sufficient to form a coagulum at the surface of the patch, and finally, permitting the coagulum to form a mechanical bond with the support or patch.

Abstract: Wounds in lung tissue are closed in a two step method consisting essentially of applying fasteners to a region adjacent to the wound, wherein the fasteners may cause penetrations. The fasteners are present in a preformed layer of collagen, fibrin, fibrinogen, elastin, albumin, or a combination thereof, and energy is applied to the region to fuse the material to the tissue and seal perforations in the tissue.

Abstract: A method for joining or restructuring tissue consists essentially of providing a preformed film or sheet of a solid filler material which fuses to tissue upon the application of energy. The material comprises collagen, gelatin, mixtures thereof, optionally combined with a plasticizer, and the film may be cut prior to placing over the tissue. Radiofrequency energy is then applied at between about 20 and 120 Watts to the filler material and the tissue after the filler material has been placed over the tissue for about 1 to 60 seconds so that about 20 to 1800 joules are delivered to the filler material and tissue.

Abstract: An anti-turbulent, anti-thrombogenic intravascular stent of a helically shaped titanium or aluminum strip having an airfoil on internal surfaces thereof for increasing blood flow through the stent without creating areas of stagnant or turbulent flow therein. Also, a method for cleaning the stent for optimum performance in the intended application, and the stents which are cleaned by the process, and novel devices for introducing the stents of the invention into the body of a patient.

Abstract: P-carboethoxy ammonium ascorbate as an anti-thrombotic compound and method of making same from ascorbic acid and ethyl p-amino benzoate.

Abstract: A method of joining or reconstructing biological tissue which comprises applying optical energy to the biological tissue while providing a collagen filler material thereto; denaturing the collagen filler material and biological tissue with the optical energy to cause joining of the collagen filler material and biological tissue, thus joining or reconstructing such tissue.

Abstract: An anti-turbulent, anti-thrombogenic intravascular stent of a helically shaped titanium or aluminum strip having an airfoil on internal surfaces thereof for increasing blood flow velocity through the stent without creating areas of stagnant or turbulent flow therein.

Abstract: A fluid flow control device of tubular means having fluid input means and fluid output means connected by a bore constituting a flow channel, means for maintaining the bore in a normally closed position, the bore being forcible to an open position in response to insertion of a medical device into the fluid input means and past the maintaining means, the maintaining means being constructed and arranged to return the bore to the closed position when the medical device is removed therefrom; and means for prevention of fluid reflux or blood from the fluid output means toward the fluid input means when the bore is in the open position.

Abstract: Methods for reducing thrombotic tendencies in a host by administering a therapeutically effective amount of p-carboethoxy ammonium ascorbate, p-carboglyceryloxy ammonium ascorbate or a mixture of esters of para amino benzoic acid and ascorbic acid.

Abstract: Methods for preventing needle-stick injuries to healthcare workers during intravenous or intra-arterial procedures as well as for preventing catheter-contamination and blood clotting within the tip of the catheter. Also, novel fluid directing means and catheters which include integral fluid flow control means for use in these methods.

Abstract: A method for preventing the introduction of air into the vascular system of a patient during intravenous or intra-arterial procedures, as well as for preventing the reflux of fluids into the body of a patient. Also, novel fluid directing means and catheters which include integral or attached fluid flow control means for use in this method.

Abstract: A composite medical article comprising a porous body, a first layer of a medicinal substance and a second layer of a medicinal substance. A method for forming a composite medical article comprising saturating a porous substrate so as to incorporate a first medicinal substance therein, preparing a coating therefor comprising a second medicinal substance with at least a portion thereof in liquid phase, affixing an onlay of the coating to the material by freezing the liquid portion of the coating to the material to form an onlaid composite medical article and drying the article. The medicinal substances may comprise either a hemostatic agent or a medicament.

Abstract: A solution of L-ascorbic acid and a solution of para amino benzoic acid are mixed and the mixture evaporated to permit recovery of a solid compound. The compound is administered to a host to reduce thrombotic tendencies.

Abstract: Methods for preventing the introduction of air into the vascular system of a patient during intravenous or intraarterial procedures, as well as for preventing the reflex of fluids into the body of a patient. Also, novel fluid directing means and catheters which include integal or attached fluid flow control means for use in these methods.

Abstract: An intravenous system is provided which includes a source of intravenous fluid, a needle or catheter for insertion into the vascular system of a patient, a pump for pumping the intravenous fluid via the needle or catheter into the patient and catheters coupling the pump to the source and to the needle. The pump includes an arrangement to terminate pumping upon an opening upon one of the catheters to ambient atmosphere. A flow control is provided in at least one of the catheters to prevent movement of air through the corresponding catheters into the patient.

Abstract: An improved hemostatic article is made by fusing an onlay of hemostatic agent to a porous body which is already impregnated with the same or with a different hemostatic agent. The hemostatic agent(s) may comprise a collagen or collagen-like substance which has been modified by rendering the surface charge thereof effectively more positive than prior to modification.

Abstract: A flow control device which consists of a tubular body having radial sets of orifices therein covered by a resilient member which defines an annular space to which the orifices are connected. The resilient member permits positive pressure to drive fluid through the orifices but prevents negative pressure from sucking air through the orifices. A spring urges the resilient member against one of the sets of orifices.

Abstract: An improved hemostatic article is made by combining collagen or a collagen-like substance with a pad or sponge. The thusly modified pad or sponge is employed to control or terminate bleeding.

Abstract: An improved hemostatic article is made by combining collagen or a collagen-like substance with a pad or sponge. The thusly modified pad or sponge is employed to control or terminate bleeding.