Patents by Inventor Philip Neil Edwards
Philip Neil Edwards has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8486962Abstract: Compounds of formula (I), and pharmaceutically acceptable salts thereof, may be used in therapy, for example as antifungal agents: (I) wherein: R1, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. Certain compounds of formula (I) are also provided. Compounds of formula (T), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.Type: GrantFiled: May 18, 2006Date of Patent: July 16, 2013Assignee: F2G Ltd.Inventors: Samantha Patricia Thomson, Rhian Teresa Davies, Nigel Mark Allanson, Alexandre Kuvshinov, Gareth Morse Davies, Philip Neil Edwards
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Publication number: 20100056511Abstract: The invention provides compounds of formula (I), and pharmaceutically acceptable salts thereof wherein: R1, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. These compounds are useful in the manufacture of medicaments for use in the prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.Type: ApplicationFiled: November 21, 2007Publication date: March 4, 2010Inventors: Robert Downham, Edward Sibley Morris, Lloyd James Payne, Philip Neil Edwards, Gareth Morse Davies
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Publication number: 20080161302Abstract: Compounds of formula (I), and pharmaceutically acceptable salts thereof, may be used in therapy, for example as antifungal agents: (I) wherein: R1, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. Certain compounds of formula (I) are also provided. Compounds of formula (T), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.Type: ApplicationFiled: May 18, 2006Publication date: July 3, 2008Applicant: F2G Ltd.Inventors: Samantha Patricia Thomson, Rhian Teresa Davies, Nigel Mark Allanson, Alexandre Kuvshinov, Gareth Morse Davies, Philip Neil Edwards
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Publication number: 20030195158Abstract: Novel peptide derivatives, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing them are useful in treating MHC class II dependent T-cell method autoimmune or inflammatory diseases, such as rheumatoid arthritis.Type: ApplicationFiled: December 16, 2002Publication date: October 16, 2003Inventors: Keith Oldham, Philip Neil Edwards, Richard William Arthur Luke, Ronald Cotton
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Patent number: 6541453Abstract: Novel peptide derivatives, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing then are useful in treating MHC class II dependent T-cell method autoimmune or inflammatory diseases, such as rheumatoid arthritis.Type: GrantFiled: May 26, 1999Date of Patent: April 1, 2003Assignee: Syngenta LimitedInventors: Keith Oldham, Philip Neil Edwards, Richard William Arthur Luke, Ronald Cotton
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Publication number: 20020103335Abstract: The invention concerns pharmaceutically useful peptide derivatives of the formula (I), P-AA I -AA 2 -AA 3 -AA 4 -AA 5 -AA 6 -AA 7 -AA 8 -Q, in which P, AA 1, AA 2, AA 3 , AA 4, AA 5, AA 6, AA 7, AA 8, and Q have the various meanings defined herein and their pharmaceutically accentable salts, and pharmaceutical compositions containing them. The novel peptide derivatives are of value in treating MHC class II dependent T-cell mediated autoimmune or inflammatory diseases, such as rheumatoid arthritis. The invention further concerns processes for the manufacture of the novel peptide derivatives and the use of the compounds in medical treatment.Type: ApplicationFiled: May 26, 1999Publication date: August 1, 2002Inventors: KEITH OLDHAM, PHILIP NEIL EDWARDS, RICHARD WILLIAM ARTHUR LUKE, RONALD COTTON
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Publication number: 20010001101Abstract: The present invention provides a phenanthroline derivative of formula (I) 1Type: ApplicationFiled: December 20, 2000Publication date: May 10, 2001Applicant: Zeneca LimitedInventors: Philip Neil Edwards, Michael Stewart Large, Neil James Hales
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Patent number: 6200974Abstract: The present invention provides a phenanthroline derivative of formula (I) wherein, for example, R1 is hydrogen, carboxy, cyano, nitro, (1-4C)alkyl, (1-6C)alkoxycarbonyl, (1-4C)alkylamino, (2-4C)alkanoyl, (1-4C)alkoxy-(2-4C)alkoxy-(2-4C)alkoxycarbonyl or N-[amino-(2-8C)alkyl]carbamoyl; R2 is, for example, hydrogen, carboxy, (1-6C)alkoxycarbonyl, carbamoyl, N-(1-8C)alkylcarbamoyl, N,N-di-(1-8C)alkylcarbamoyl, N-(1-4C)alkylcyclohexylcarbamoyl, 1,2,3,4-tetrahydro-isoquinolin-2-ylcarbonyl or N,N-[di-(1-4C)alkyl]thiocarbamoyl; R3 and R4, which may be the same or different, are, for example, hydrogen or halo; and R5 is, for example, hydrogen, di-(1-4C)alkylamino or halo; or a pharmaceutically-acceptable salt thereof. The invention further provides pharmaceutical compositions comprising phenanthroline derivatives, processes for making the same and their use in producing an anti-fibroproliferative effect.Type: GrantFiled: May 4, 1999Date of Patent: March 13, 2001Assignee: Zeneca LimitedInventors: Philip Neil Edwards, Michael Stewart Large, Neil James Hales
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Patent number: 6087336Abstract: The invention concerns pharmaceutically useful peptide derivatives of the formula (I): P--R.sup.1 --R.sup.2 --R.sup.3 --R.sup.4, in which P, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 have the various meanings defined herein, and their pharmaceutically acceptable salts, and pharmaceutical compositions containing them. The novel peptide derivatives are of value in treating MHC class II dependent T-cell mediated autoimmune or inflammatory diseases, such as rheumatoid arthritis. The invention further concerns processes for the manufacture of the novel peptide derivatives and the use of the compounds in medical treatment.Type: GrantFiled: August 20, 1998Date of Patent: July 11, 2000Assignee: Zeneca LimitedInventors: Philip Neil Edwards, Richard William Arthur Luke, Ronald Cotton
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Patent number: 5916898Abstract: The present invention provides a phenanthroline derivative of formula (I) ##STR1## wherein, for example, R.sup.1 is hydrogen, carboxy, cyano, nitro, (1-4C)alkyl, (1-6C)alkoxycarbonyl, (1-4C)alkylamino, (2-4C)alkanoyl, (1-4C)alkoxy-(2-4C)alkoxy-(2-4C)alkoxycarbonyl or N-?amino-(2-8C)alkyl!carbamoyl;R.sup.2 is, for example, hydrogen, carboxy, (1-6C)alkoxycarbonyl, carbamoyl, N-(1-8C)alkylcarbamoyl, N,N-di-(1-8C)alkylcarbamoyl, N-(1-4C)alkylcyclohexylcarbamoyl, 1,2,3,4-tetrahydro-isoquinolin-2-ylcarbonyl or N,N-?di-(1-4C)alkyl!thiocarbamoyl;R.sup.3 and R.sup.4, which may be the same or different, are, for example, hydrogen or halo; andR.sup.5 is, for example, hydrogen, di-(1-4C)alkylamino or halo; or a pharmaceutically-acceptable salt thereof.The invention further provides pharmaceutical compositions comprising phenanthroline derivatives, processes for making the same and their use in producing an anti-fibroproliferative effect.Type: GrantFiled: October 24, 1997Date of Patent: June 29, 1999Assignee: Zeneca LimitedInventors: Philip Neil Edwards, Michael Stewart Large, Neil James Hales
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Patent number: 3939169Abstract: Bis(pyridinium quaternary salts), typically those of the formula: ##SPC1## wherein R.sup.1 and R.sup.2, which may be the same or different, are each an alkyl having 8 to 14 carbon atoms, n-undec-10-yl, 2-n-hexyloxyethyl, 2-(2-butoxyethoxy)ethyl, 3,4-dichlorophenyl, 4-chlorobenzyl, 2,4-dichlorobenzyl or 2-naphthylmethyl; A.sup.1 and A.sup.2 are each a direct linkage or a linking group of the formula:--CH.sub.2 CO.NH--wherein the methylene is joined to the pyridine nitrogen; (X.sup.1.X.sup.2).sup.2.sup.- represents two mono-anions or a dianion selected from the group consisting of two halide, methanesulphonate, toluene-p-sulphonate or acetate anions or the sulphate dianion; and A.sup.3 is a linking group of the formula:--(CH.sub.2).sub.n H.CO.NH(CH.sub.2).sub.y NH.CO.NH(CH.sub.2).sub.n --Wherein n is 0, 1 or 2; and y is 0 or 2 to 6.Type: GrantFiled: December 27, 1973Date of Patent: February 17, 1976Assignee: Imperial Chemical Industries LimitedInventor: Philip Neil Edwards