Abstract: A machine learning predictor model is trained to generate a prediction of the appearance of a tissue sample stained with a special stain such as an IHC stain from an input image that is either unstained or stained with H&E. Training data takes the form of thousands of pairs of precisely aligned images, one of which is an image of a tissue specimen stained with H&E or unstained, and the other of which is an image of the tissue specimen stained with the special stain. The model can be trained to predict special stain images for a multitude of different tissue types and special stain types, in use, an input image, e.g., an H&E image of a given tissue specimen at a particular magnification level is provided to the model and the model generates a prediction of the appearance of the tissue specimen as if it were stained with the special stain. The predicted image is provided to a user and displayed, e.g., on a pathology workstation.

Abstract: A machine learning predictor model is trained to generate a prediction of the appearance of a tissue sample stained with a special stain such as an IHC stain from an input image that is either unstained or stained with H&E. Training data takes the form of thousands of pairs of precisely aligned images, one of which is an image of a tissue specimen stained with H&E or unstained, and the other of which is an image of the tissue specimen stained with the special stain. The model can be trained to predict special stain images for a multitude of different tissue types and special stain types, in use, an input image, e.g., an H&E image of a given tissue specimen at a particular magnification level is provided to the model and the model generates a prediction of the appearance of the tissue specimen as if it were stained with the special stain. The predicted image is provided to a user and displayed, e.g., on a pathology workstation.

Abstract: A machine learning predictor model is trained to generate a prediction of the appearance of a tissue sample stained with a special stain such as an IHC stain from an input image that is either unstained or stained with H&E. Training data takes the form of thousands of pairs of precisely aligned images, one of which is an image of a tissue specimen stained with H&E or unstained, and the other of which is an image of the tissue specimen stained with the special stain. The model can be trained to predict special stain images for a multitude of different tissue types and special stain types, in use, an input image, e.g., an H&E image of a given tissue specimen at a particular magnification level is provided to the model and the model generates a prediction of the appearance of the tissue specimen as if it were stained with the special stain. The predicted image is provided to a user and displayed, e.g., on a pathology workstation.

Abstract: A signal processor for a sound reproduction system which is arranged to perform processing of a sound recording so as to provide input signals for an array of distributed loudspeakers, such that the sound field generated by the loudspeakers results in cross-talk cancellation in respect of multiple listener positions at substantially all frequencies reproduced by the loudspeakers, and wherein the sound field so generated is an approximation of a sound field produced by an Optimal Source Distribution, OSD.

Abstract: A signal processor for a sound reproduction system which is arranged to perform processing of a sound recording so as to provide input signals for an array of distributed loudspeakers, such that the sound field generated by the loudspeakers results in cross-talk cancellation in respect of multiple listener positions at substantially all frequencies reproduced by the loudspeakers, and wherein the sound field so generated is an approximation of a sound field produced by an Optimal Source Distribution, OSD.

Abstract: A machine learning predictor model is trained to generate a prediction of the appearance of a tissue sample stained with a special stain such as an IHC stain from an input image that is either unstained or stained with H&E. Training data takes the form of thousands of pairs of precisely aligned images, one of which is an image of a tissue specimen stained with H&E or unstained, and the other of which is an image of the tissue specimen stained with the special stain. The model can be trained to predict special stain images for a multitude of different tissue types and special stain types, in use, an input image, e.g., an H&E image of a given tissue specimen at a particular magnification level is provided to the model and the model generates a prediction of the appearance of the tissue specimen as if it were stained with the special stain. The predicted image is provided to a user and displayed, e.g., on a pathology workstation.

Abstract: The disclosure relates to an apparatus for generating a sound field on the basis of an input audio signal. The apparatus comprises a plurality of transducers, wherein each transducer is configured to be driven by a transducer driving signal ql of the respective transducer; a plurality of filters configured to generate for each transducer the transducer driving signal ql of the respective transducer; and a control unit configured to provide or receive a first transducer driving signal vector q0 of dimension L such that the gradient of J(q;?) with respect to q is zero in (q0;?0), the control unit is further configured to provide a second transducer driving signal vector {tilde over (q)} of dimension L such that the gradient of the cost function J(q;?) with respect to q is [approximately] zero in ({tilde over (q)}; {tilde over (?)}), the control unit is configured to provide the second transducer driving signal vector {tilde over (q)}.

Abstract: The disclosure relates to an apparatus for generating a sound field on the basis of an input audio signal. The apparatus comprises a plurality of transducers, wherein each transducer is configured to be driven by a transducer driving signal ql of the respective transducer; a plurality of filters configured to generate for each transducer the transducer driving signal ql of the respective transducer; and a control unit configured to provide or receive a first transducer driving signal vector q0 of dimension L such that the gradient of J(q;?) with respect to q is zero in (q0;?0), the control unit is further configured to provide a second transducer driving signal vector {tilde over (q)} of dimension L such that the gradient of the cost function J(q;?) with respect to q is [approximately] zero in ({tilde over (q)};{tilde over (?)}), the control unit is configured to provide the second transducer driving signal vector {tilde over (q)}.

Abstract: Method and, apparatus for implementing the method, the method comprising determining control signal data for an array of loudspeakers, the control signal data being such as to control the loudspeakers to produce a desired sound field associated with an audio signal, the method comprises determining control signal data for different frequency components of the desired sound field in respect of respective different positions in a listening volume of the loudspeaker array, wherein determination of the control signal data comprises sampling the desired sound field at the surface of a control volume (V).

Abstract: Method and, apparatus for implementing the method, the method comprising determining control signal data for an array of loudspeakers, the control signal data being such as to control the loudspeakers to produce a desired sound field associated with an audio signal, the method comprises determining control signal data for different frequency components of the desired sound field in respect of respective different positions in a listening volume of the loudspeaker array, wherein determination of the control signal data comprises sampling the desired sound field at the surface of a control volume (V).

Abstract: A manually operated trigger sprayer includes a feature that limits the forward pivoting movement of the trigger. By limiting the forward pivoting movement of the trigger, the novel construction of the trigger sprayer prevents the trigger from engaging against the nozzle assembly attached to the sprayer housing of the trigger sprayer and potentially dislodging the nozzle assembly from its attachment to the trigger sprayer housing.

Abstract: The present invention pertains to the construction of a manually operated trigger sprayer in which the sprayer housing has a reduced diameter dimension liquid discharge passage to increase the velocity of liquid flow through the liquid discharge passage, and in which the nozzle assembly has a novel configuration that securely attaches the nozzle assembly to the sprayer housing to prevent the increased velocity of liquid flow through the sprayer housing liquid discharge passage from dislodging the nozzle assembly from the sprayer housing. The novel construction of the sprayer housing and the nozzle assembly includes a resilient crossbar provided on the sprayer housing that crosses over the liquid discharge passage and a pair of resilient flanges on the nozzle assembly that engage over opposite sides of the sprayer assembly crossbar and securely attaching the nozzle assembly to the sprayer housing.

Abstract: A trigger sprayer has a venting apparatus with a unique construction that is formed by the combination of a sprayer housing of the trigger sprayer and a plug seal assembled to the sprayer housing. The plug seal includes a dip tube connector, a valve seat, an annular rim seal, and a portion of the air vent baffle apparatus that are combined as one integral piece.

Abstract: A manually operated trigger sprayer is constructed with a reduced number of parts and in a novel manner in which all of the component parts of the sprayer are constructed of a plastic material. The construction of the trigger sprayer replaces the conventional metal coil spring in the pump chamber with a pair of plastic bowed springs that are integral with the piston rod and are positioned outside the pump chamber. Constructing all of the sprayer parts of a plastic material enables a cost efficient recycling of the parts, which does not require disassembling the parts to remove a metal spring.

Abstract: A manually operated trigger sprayer is constructed with a reduced number of parts and in a novel manner in which all of the component parts of the sprayer are constructed of a plastic material. The construction of the trigger sprayer replaces the conventional metal coil spring in the pump chamber with a pair of plastic springs having inverted U-shaped configurations that are integral with the piston rod and are positioned outside the pump chamber. Constructing all of the sprayer parts of a plastic material enables a cost efficient recycling of the parts, which does not require disassembling the parts to remove a metal spring.

Abstract: A manually operated pump dispenser is attached to the top of a bottle of liquid and pumps and dispenses liquid from the bottle. The dispenser includes a pump housing containing a liquid pump chamber, and a pump plunger that is manually reciprocated in the pump chamber. A liquid piston is mounted on the pump plunger and is reciprocated in the pump chamber by the pump plunger. The liquid piston is mounted on the pump plunger for limited axial movement of the piston on the plunger. The movement of the piston on the plunger opens and closes a liquid flow path between the interior of the liquid pump chamber and a liquid discharge passage passing through the pump plunger.

Abstract: A closure is removably attachable to a container and comprises a dispensing orifice and a valve element that is biased closed over the orifice. By inverting the container so that a liquid contents of the container exerts pressure on the valve element, or by squeezing the container causing the liquid contents to exert pressure on the valve element, the valve element opens the dispensing orifice allowing the liquid contents to be dispensed from the container. On removing the pressure from the valve element, the valve element resiliently closes the dispensing orifice.

Abstract: One or more server-based constructs are projected into one or more corresponding desktop objects. Thereafter one or more events involving the desktop objects are processed according to behaviors defined during the projection using action handlers cached at a desktop client. The action handlers provide a mechanism for instituting the server-defined behaviors at the desktop, including the playing of locally cached web forms that provide a user with options for interacting with the desktop objects according to those behaviors. Any or all interactions with the desktop objects may be subsequently communicated to the server, which can accept or reject any changes and resynchronize an updated view of the object(s) to the desktop client.

Abstract: A manually operated vertically reciprocated pump dispenser has a simplified construction with two separate pumps that pump two separate liquids from a container and keep the two separate liquids separated from each other as they are pumped through the dispenser, mixing the liquids for the first time in a discharge passage of the dispenser just prior to the mixed liquids being discharged from the dispenser. The dispenser has a rotatable sleeve that covers the two pumps and is rotated to lock and unlock a dispenser head that operates the two pumps.

Abstract: This invention provides an apparatus and method for processing produce to reduce microorganisms thereon by treating the produce in a treatment chamber. The treatment chamber comprises a produce receiver disposed in the treatment chamber, a means for providing a gas stream comprising chlorine dioxide and a carrier gas into the treatment chamber, a chlorine dioxide sensor in communication with the treatment chamber, and a means for controlling the concentration of chlorine dioxide in the treatment chamber. The method comprises exposing the produce to an atmosphere comprising gaseous chlorine dioxide and a carrier gas in a treatment chamber and can comprise controlling the concentration of chlorine dioxide in the treatment chamber, moving the produce in the treatment chamber during exposure to the gaseous chlorine dioxide, spraying water to remove the gaseous chlorine dioxide, and purging the treatment chamber to remove any residual chlorine dioxide.