Abstract: A system and method for controlling a light emitting device for an optical sensor based on signal quality and/or power consumption requirements. Drive current and/or integration time is controlled as a function of detected ambient light or signal quality. As the signal quality decreases the drive current or integration time can be adjusted to provide a more usable signal. If after some criteria for reduction, such as “time on” or high signal quality, then the drive current can be decreased.

Abstract: Systems and methods for facilitating reservations of shared desks, phone booths, and other spaces or areas within a workspace for members of the workspace are described. For example, a space reservation system receives a request to reserve a space for a member and selects a space suitable for the member based on one or more work environment characteristics associated with the space. The system also presents various interfaces for displaying available spaces and facilitating interactions between the member and the space.

Abstract: A system and method for controlling a light emitting device for an optical sensor based on signal quality and/or power consumption requirements. Drive current and/or integration time is controlled as a function of detected ambient light or signal quality. As the signal quality decreases the drive current or integration time can be adjusted to provide a more usable signal. If after some criteria for reduction, such as “time on” or high signal quality, then the drive current can be decreased.

Abstract: An augmented reality display system comprises a passable world model data comprises a set of map points corresponding to one or more objects of the real world. The augmented reality system also comprises a processor to communicate with one or more individual augmented reality display systems to pass a portion of the passable world model data to the one or more individual augmented reality display systems, wherein the piece of the passable world model data is passed based at least in part on respective locations corresponding to the one or more individual augmented reality display systems.

Abstract: A handheld device includes a contact surface, an optical module, a processor, a display module, and a user operable switch. The optical module is disposed on the contact surface. The optical module has at least one optical emitter and at least one optical detector. The at least one optical detector has a light shield associated with the contact surface. The light shield is configured to exclude ambient light from the contact surface when the contact surface abuts tissue of a patient. The processor is coupled to the optical module and configured to execute instructions for determining a measure of oximetry corresponding to the tissue. The display module is coupled to the processor and is configured to indicate the measure of oximetry. The user operable switch is configured to activate at least one of the processor, the optical module, and the display module.

Abstract: A new, stable trimeric TNF? structure is disclosed with distorted symmetry which can bind to the TNFR1 receptor to attenuate signalling therefrom, which can be used in the treatment and/or prevention of diseases associated with the soluble TNF?/TNFR1 interaction. Membrane-bound TNF? is not affected in its ability to signal through TNFR2, and thus the new structure of TNF? may be used in therapies which do not significantly raise the risk of infection or malignancy.

Abstract: The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.

Abstract: An augmented reality device comprises one or more sensors to detect a property pertaining to an ambient light, a processor communicatively coupled to the one or more sensors to modify a characteristic associated with a virtual image to be projected to the user of a head-mounted augmented reality system based at least in part on the detected property, and an optical sub-system to project light associated with the virtual image having the modified characteristic.

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. A new assay for identifying compounds with this mechanism of action is also disclosed.

Abstract: An augmented reality device comprises one or more sensors to detect a property pertaining to an ambient light, a processor communicatively coupled to the one or more sensors to modify a characteristic associated with a virtual image to be projected to the user of a head-mounted augmented reality system based at least in part on the detected property, and an optical sub-system to project light associated with the virtual image having the modified characteristic.

Abstract: A virtual image generation system and method of operating same is provided. An end user is allowed to visualize the object of interest in a three-dimensional scene. A text region is spatially associated with the object of interest. A textual message that identifies at least one characteristic of the object of interest is generated. A textual message is streamed within the text region.

Abstract: A parallel decompression engine has separate hardware paths for sequence processing and repeated byte copying/placement. Literal byte extraction logic obtains literal bytes from a selected sequence. Literal byte write logic writes the obtained literal bytes into an uncompressed data set that is being generated. Offset and length extraction logic obtains the offset and length of repeated bytes from the selected sequence. In a separate hardware path, copying and placement logic uses the offset and length to find and copy the length of repeated bytes at the specified offset in the uncompressed data set, and place the copied repeated bytes back into the uncompressed data set adjacent to the literal bytes.

Abstract: An augmented reality display system comprises a passable world model data comprises a set of map points corresponding to one or more objects of the real world. The augmented reality system also comprises a processor to communicate with one or more individual augmented reality display systems to pass a portion of the passable world model data to the one or more individual augmented reality display systems, wherein the piece of the passable world model data is passed based at least in part on respective locations corresponding to the one or more individual augmented reality display systems.

Abstract: An augmented reality display system comprises a passable world model data comprises a set of map points corresponding to one or more objects of the real world. The augmented reality system also comprises a processor to communicate with one or more individual augmented reality display systems to pass a portion of the passable world model data to the one or more individual augmented reality display systems, wherein the piece of the passable world model data is passed based at least in part on respective locations corresponding to the one or more individual augmented reality display systems.

Abstract: The present disclosure provides a method of dual-phase hot metal extrusion comprising (i) providing a load carrier made of a first metal material, wherein the load carrier comprises one or more load chambers containing a second metal material, wherein the melting point of the second metal material is lower than the melting point of the first metal material, (ii) heating the load carrier to a temperature above the melting point of the second metal material and suitable for extrusion of the load carrier, and (iii) extruding the load carrier to form an extruded product. The present disclosure also provides apparatuses for accomplishing the dual-phase hot extrusion of metals and products resulting from such processes.

Abstract: An LED lamp comprising: a plurality of LED strings, each LED string comprising a plurality of LEDs; a plurality of constant current circuits for powering the plurality of LED strings, wherein one constant current circuit is provided for each LED string; a plurality of shift registers for controlling the operation of the plurality of constant current circuits, wherein at least one shift register is provided for each LED string; and a microprocessor for supplying timing pulses to the plurality of shift registers for controlling operation of the plurality of constant current circuits, the timing pulses comprising a plurality of serial bit streams.

Abstract: A device includes a sensor for measuring a parameter for tissue. The sensor includes a plurality of optical elements including a plurality of detectors and at least one emitter. Separation distances between the various optical elements are selected based on a depth corresponding to a region of interest in the tissue and based on a depth corresponding to an exclusion region in the tissue.

Abstract: An apparatus includes a sensor body, a circuit board, a cable, at least one light emitting device, and at least one photodetector. The circuit board is enclosed within the sensor body and includes at least one conductive trace and at least one aperture. The cable is coupled to the at least one conductive trace. The cable includes a shield conductor and a signal conductor. The at least one light emitting device is coupled to the circuit board and is configured to emit light into a tissue. The at least one photodetector includes a planar active area coupled to the circuit board and is configured to provide an output signal based on light detected by the active area. The planar active area is aligned with the aperture. The output signal is coupled to the cable.