Abstract: The present invention relates to a handheld dental device that provides photodynamic therapy. The device of the present invention may have an elongated housing; an applicator tip extending from the distal end of the housing; wherein the applicator tip has a lumen defined by a wall; an optic fiber extending through the lumen of the applicator tip; at least one power source attached to or residing within the housing; at least one light source that provides light to the optic fiber and emits a wavelength that ranges from about 650 nm to about 1400 nm; and at least one oxygen source that provides oxygen to a passage that communicates with the oxygen source and the applicator tip. Oxygen and light may be provided at the applicator tip simultaneously. The device may be used to eliminate or reduce bacteria which cause oral disease or conditions, such as endodontic treatment failures.

Abstract: The present invention relates to oral antibacterial compositions comprising trihydroxybenzoate derivatives, e.g., useful for the treatment of gum diseases (e.g., gingivitis or periodontitis) and to methods of using such compositions.

Abstract: The present invention relates to oral antibacterial compositions comprising trihydroxybenzoate derivatives, e.g., useful for the treatment of gum diseases (e.g., gingivitis or periodontitis) and to methods of using such compositions.

Abstract: The present invention relates to oral antibacterial compositions comprising trihydroxybenzoate derivatives, e.g., useful for the treatment of gum diseases (e.g., gingivitis or periodontitis) and to methods of using such compositions.

Abstract: Endodontic fibers comprising a biocompatible polymer vehicle permeable to medicaments, or combinations of medicaments, wherein the biocompatible polymer vehicle comprises one or more biocompatible and/or biodegradable polymers are described. Such fibers can be used, for example, in a method for the local delivery and sustained release of medicaments to periodontal or intracanal treatment sites. Endodontic fibers described include periodontal fibers and intracanal fibers.

Abstract: The present invention relates to new methods for making antibodies that involves chemically modifying the antigen with methylglyoxal. The present invention further relates to antibodies made in this manner, and include antibodies specific to LL-37. The present invention pertains to assays that utilize anti-LL-37 antibodies and assess compounds that stimulate LL-37 production. Such compounds are useful in antimicrobial compositions.