Patents by Inventor Philip R. Dormitzer

Philip R. Dormitzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RSV F PROTEIN COMPOSITIONS AND METHODS FOR MAKING SAME
    Publication number: 20220372115
    Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.
    Type: Application
    Filed: June 23, 2022
    Publication date: November 24, 2022
    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Kurt SWANSON, Philip R. DORMITZER
  • RSV F PROTEIN COMPOSITIONS AND METHODS FOR MAKING SAME
    Publication number: 20220340645
    Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.
    Type: Application
    Filed: June 23, 2022
    Publication date: October 27, 2022
    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Kurt SWANSON, Philip R. DORMITZER
  • RSV F PROTEIN COMPOSITIONS AND METHODS FOR MAKING SAME
    Publication number: 20220213177
    Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.
    Type: Application
    Filed: December 29, 2021
    Publication date: July 7, 2022
    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Kurt SWANSON, Philip R. DORMITZER
  • RSV F protein compositions and method for making same
    Patent number: 11261239
    Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: March 1, 2022
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Kurt Swanson, Philip R. Dormitzer
  • RSV F PROTEIN COMPOSITIONS AND METHOD FOR MAKING SAME
    Publication number: 20200172600
    Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.
    Type: Application
    Filed: August 16, 2017
    Publication date: June 4, 2020
    Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA
    Inventors: Kurt Swanson, Philip R. Dormitzer
  • Norovirus derived immunogenic compositions and methods
    Patent number: 10287324
    Abstract: The invention relates to chimeric norovirus VP1 proteins containing the S-domain of VP1 of a first norovirus strain and a P-domain that contains at least a portion of the P-domain of VP1 of a second norovirus strain. The invention also relates to nucleic acids that encode the chimeric VP1 proteins, virus-like particles that contain a chimeric norovirus VP1 protein, and to immunogenic compositions.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: May 14, 2019
    Assignee: NOVARTIS AG
    Inventors: Ethan Settembre, Angelica Medina-Selby, Doris Coit, Philip R. Dormitzer
  • Rotavirus particles with chimeric surface proteins
    Patent number: 10192025
    Abstract: The present invention relates to the use of rotavirus particles for displaying a heterologous protein, alone or in complex with another molecule. The invention further relates to methods that employ these modified rotavirus particles to rapidly determine the structure of the heterologous protein or the complex using cryo-electron microscopy (cryo-EM). The invention also relates to a method of immunizing a patient, wherein said method comprises administering to the patient the modified rotavirus particles of the invention.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: January 29, 2019
    Assignee: Novartis AG
    Inventors: Philip R. Dormitzer, Nikolaus Grigorieff, Stephen Harrison, Junhua Pan, Ethan Settembre
  • NOROVIRUS DERIVED IMMUNOGENIC COMPOSITIONS AND METHODS
    Publication number: 20190023746
    Abstract: The invention relates to chimeric norovirus VP1 proteins containing the S-domain of VP1 of a first norovirus strain and a P-domain that contains at least a portion of the P-domain of VP1 of a second norovirus strain.
    Type: Application
    Filed: August 2, 2018
    Publication date: January 24, 2019
    Inventors: Ethan Settembre, Angelica Medina-Selby, Doris Coit, Philip R. Dormitzer
  • Norovirus derived immunogenic compositions and methods
    Patent number: 10065994
    Abstract: The invention relates to chimeric norovirus VP1 proteins containing the S-domain of VP1 of a first norovirus strain and a P-domain that contains at least a portion of the P-domain of VP1 of a second norovirus strain. The invention also relates to nucleic acids that encode the chimeric VP1 proteins, virus-like particles that contain a chimeric norovirus VP1 protein, and to immunogenic compositions.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: September 4, 2018
    Assignee: Novartis AG
    Inventors: Ethan Settembre, Angelica Medina-Selby, Doris Coit, Philip R. Dormitzer
  • Method for generating a parvovirus B19 virus-like particle
    Patent number: 9744228
    Abstract: The invention provides a process for generating parvovirus VP1/VP2 virus like particles (VLPs). The invention further provides methods for purification of the parvovirus VLPs and immunogenic compositions that contain the VLPs. The invention also includes recombinant nucleic acid molecules that encode parvovirus VP1 and VP2, and host cells that contain the recombinant nucleic acids.
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: August 29, 2017
    Assignee: Norvartis AG
    Inventors: Ethan Settembre, Angelica Medina-Selby, Doris Coit, Philip R. Dormitzer
  • NOROVIRUS DERIVED IMMUNOGENIC COMPOSITIONS AND METHODS
    Publication number: 20160222066
    Abstract: The invention relates to chimeric norovirus VP1 proteins containing the S-domain of VP1 of a first norovirus strain and a P-domain that contains at least a portion of the P-domain of VP1 of a second norovirus strain.
    Type: Application
    Filed: November 19, 2015
    Publication date: August 4, 2016
    Inventors: Ethan Settembre, Angelica MEDINA-SELBY, Doris COIT, Philip R. DORMITZER
  • ROTAVIRUS PARTICLES WITH CHIMERIC SURFACE PROTEINS
    Publication number: 20160188790
    Abstract: The present invention relates to the use of rotavirus particles for displaying a heterologous protein, alone or in complex with another molecule. The invention further relates to methods that employ these modified rotavirus particles to rapidly determine the structure of the heterologous protein or the complex using cryo-electron microscopy (cryo-EM). The invention also relates to a method of immunising a patient, wherein said method comprises administering to the patient the modified rotavirus particles of the invention.
    Type: Application
    Filed: July 8, 2014
    Publication date: June 30, 2016
    Inventors: Philip R. Dormitzer, Nikolaus Grigorieff, Stephen Harrison, Junhua Pan, Ethan Settembre
  • Rotavirus antigens
    Patent number: 8685411
    Abstract: The present invention relates to novel recombinant polypeptide antigens that may comprise subunit vaccines against rotavirus infection. Further, the present invention relates to methods for use of said antigens in the diagnosis, treatment and prevention of rotavirus infection.
    Type: Grant
    Filed: January 3, 2007
    Date of Patent: April 1, 2014
    Assignees: Children's Medical Center Corporation, The Board of Trustees of the Leland Stanford Junior University, The United States of America as represented by the National Institutes of Health (NIH), The United States of America as represented by the Dept. of Health and Human Services (DHHS)
    Inventors: Philip R. Dormitzer, Stephen C. Harrison, Harry B. Greenberg, Joshua Yoder
  • METHOD FOR GENERATING A PARVOVIRUS B19 VIRUS-LIKE PARTICLE
    Publication number: 20130273109
    Abstract: The invention provides a process for generating parvovirus VP1/VP2 virus like particles (VLPs). The invention further provides methods for purification of the parvovirus VLPs and immunogenic compositions that contain the VLPs. The invention also includes recombinant nucleic acid molecules that encode parvovirus VP1 and VP2, and host cells that contain the recombinant nucleic acids.
    Type: Application
    Filed: April 7, 2011
    Publication date: October 17, 2013
    Applicant: NOVARTIS AG
    Inventors: Ethan Settembre, Angelica Medina-Selby, Doris Coit, Philip R. Dormitzer
  • NOROVIRUS DERIVED IMMUNOGENIC COMPOSITIONS AND METHODS
    Publication number: 20130171185
    Abstract: The invention relates to chimeric norovirus VP1 proteins containing the S-domain of VP1 of a first norovirus strain and a P-domain that contains at least a portion of the P-domain of VP1 of a second norovirus strain. The invention also relates to nucleic acids that encode the chimeric VP1 proteins, virus-like particles that contain a chimeric norovirus VP1 protein, and to immunogenic compositions.
    Type: Application
    Filed: July 5, 2011
    Publication date: July 4, 2013
    Inventors: Ethan Settembre, Angelica Medina-Selby, Doris Coit, Philip R. Dormitzer
  • RSV F PROTEIN COMPOSITIONS AND METHODS FOR MAKING SAME
    Publication number: 20110305727
    Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.
    Type: Application
    Filed: July 15, 2010
    Publication date: December 15, 2011
    Applicant: Novartis AG
    Inventors: Kurt Swanson, Philip R. Dormitzer