Patents by Inventor Philip R. Hamann

Philip R. Hamann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 3-cyano-[1.7], [1.5], and [1.8] naphthyridine inhibitors of tyrosine kinases
    Patent number: 6548496
    Abstract: This invention provides compounds of formula I having the structure Wherein substitutions at A″, Z, n, and X are set forth in the specification.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: April 15, 2003
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Philip R. Hamann, Ayako Yamashita
  • Substituted 3-cyano-[1.7], [1.5], and [1.8] naphthyridine inhibitors of tyrosine kinases
    Publication number: 20020165229
    Abstract: This invention provides compounds of formula I having the structure 1
    Type: Application
    Filed: December 21, 2001
    Publication date: November 7, 2002
    Applicant: American Cyanamid Company
    Inventors: Allan Wissner, Philip R. Hamann, Ayako Yamashita
  • Substituted 3-cyano-[1.7],[1.5], and [1.8] naphthyridine inhibitors of tyrosine kinases
    Patent number: 6355636
    Abstract: This invention provides compounds of formula I having the structure useful as inhibitors of protein tyrosine kinase.
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: March 12, 2002
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Philip R. Hamann, Ayako Yamashita
  • Substituted 3-cyanoquinolines
    Patent number: 6297258
    Abstract: This invention provides compounds of formula I having the structure wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
    Type: Grant
    Filed: August 1, 2000
    Date of Patent: October 2, 2001
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Hwei-Ru Tsou, Dan M. Berger, Middleton B. Floyd, Jr., Philip R. Hamann, Nan Zhang, Philip Frost
  • Substituted 3-cyanoquinolines
    Patent number: 6288082
    Abstract: This invention provides compounds of formula I having the structure wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: September 11, 2001
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Hwei-Ru Tsou, Dan M. Berger, Middleton B. Floyd, Jr., Philip R. Hamann, Nan Zhang, Mark E. Salvati, Philip Frost
  • Substituted quinazoline derivatives
    Patent number: 6251912
    Abstract: This invention provides compounds of formula 1 having the structure wherein: X, R1, R2, R3, R4, Z, X, and n are as defined hereinbefore in the specification, which are useful as antineoplastic agents and in the treatment of certain kidney diseases, such as polycystic kidney disease.
    Type: Grant
    Filed: July 29, 1998
    Date of Patent: June 26, 2001
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Hwei-Ru Tsou, Bernard D. Johnson, Philip R. Hamann, Nan Zhang
  • Targeted forms of methyltrithio antitumor agents
    Patent number: 6015562
    Abstract: The invention is humanized CT-M-01 monoclonal antibody molecule-drug conjugates prepared from the family of methyltrithio antitumor agents.
    Type: Grant
    Filed: February 16, 1996
    Date of Patent: January 18, 2000
    Assignee: American Cyanamid Company
    Inventors: Lois M. Hinman, Philip R. Hamann
  • Process for preparing targeted forms of methyltrithio antitumor agents
    Patent number: 5770701
    Abstract: This disclosure describes a method for constructing targeting agent drug conjugates from the family of methyltrithio antibacterial and antitumor agents.
    Type: Grant
    Filed: October 26, 1994
    Date of Patent: June 23, 1998
    Assignee: American Cyanamid Company
    Inventors: William James McGahren, Martin Leon Sassiver, George A. Ellestad, Philip R. Hamann, Lois M. Hinman, Janis Upeslacis
  • Phosphocholine derivative inhibitors of phospholipase A.sub.2
    Patent number: 5208223
    Abstract: Phospocholine derivatives having the formula: ##STR1## in which W, Z, Q and R are described in the specification are disclosed as useful for inhibiting the enzyme phospholipase A.sub.2. Methods of making and using the compounds are also disclosed.
    Type: Grant
    Filed: June 3, 1992
    Date of Patent: May 4, 1993
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Robert E. Schaub, Kenneth E. Green, Philip R. Hamann
  • Phosphocholine derivative inhibitors of phospholipase A.sub.2
    Patent number: 5144045
    Abstract: Phospocholine derivatives having the formula: ##STR1## in which W, Z, Q and R are described in the specification are disclosed as useful for inhibiting the enzyme phospholipase A.sub.2. Methods of making and using the compounds are also disclosed.
    Type: Grant
    Filed: November 13, 1990
    Date of Patent: September 1, 1992
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Robert E. Schaub, Kenneth E. Green, Philip R. Hamann
  • Targeted forms of methyltrithio antitumor agents
    Patent number: 5053394
    Abstract: This disclosure describes a method for constructing carrier-drug conjugates from the family of methyltrithio antibacterial and antitumor agents.
    Type: Grant
    Filed: April 14, 1989
    Date of Patent: October 1, 1991
    Assignee: American Cyanamid Company
    Inventors: George A. Ellestad, William J. McGahren, Martin L. Sassiver, Philip R. Hamann, Lois M. Hinman, Janis Upeslacis
  • Compounds and methods useful for the synthesis of thromboxane A.sub.2
    Patent number: 4782081
    Abstract: Compounds having the structure: ##STR1## wherein X may be hydrogen, bromine, chlorine, fluorine or iodine are provided, together with methods for synthesizing these compounds, pharmaceutical compositions and use thereof for reducing vascular blood flow.Also provided are compounds having the structure: ##STR2## wherein X may be bromine, chlorine, fluorine or iodine, together with methods for preparing the compounds, pharmaceutical compositions and use thereof for reducing vascular blood flow.
    Type: Grant
    Filed: October 22, 1986
    Date of Patent: November 1, 1988
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: W. Clark Still, Philip R. Hamann, Shripad S. Bhagwat
  • Precursors and synthesis of methyl-9-oxo-11.alpha.,16-dihydroxy-16-vinyl-5-cis-13-trans-prostadienoa tes
    Patent number: 4762935
    Abstract: This disclosure describes novel compounds which are useful as precursors in the synthesis of 9-oxo-11.alpha.,16-dihydroxy-16-vinyl-5-cis-13-trans-prostadienoate esters which possess activity as hypotensive agents and/or as vasodilators.
    Type: Grant
    Filed: October 6, 1986
    Date of Patent: August 9, 1988
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Kenneth E. Green, Philip R. Hamann, Jeremy Levin
  • Compounds and methods useful for the synthesis of thromboxane A.sub.2
    Patent number: 4672131
    Abstract: Compounds having the structure: ##STR1## wherein X may be hydrogen, bromine, chlorine, fluorine or iodine are provided, together with methods for synthesizing these compounds, pharmaceutical compositions and use therof for reducing vascular blood flow.Also provided are compounds having the structure: ##STR2## wherein X may be bromine, chlorine, fluorine or iodine, together with methods for preparing the compounds, pharmaceutical compositions and use thereof for reducing vascular blood flow.
    Type: Grant
    Filed: May 30, 1985
    Date of Patent: June 9, 1987
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: W. Clark Still, Philip R. Hamann, Shripad S. Bhagwat
  • Substituted 3-cyanoquinolines
    Patent number: RE42376
    Abstract: This invention provides compounds of formula I having the structure wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: May 17, 2011
    Assignee: Wyeth Holdings Corporation
    Inventors: Allan Wissner, Hwei-Ru Tsou, Dan M. Berger, Middleton B. Floyd, Jr., Philip R. Hamann, Nan Zhang, Philip Frost