Patents by Inventor Philip R. Page
Philip R. Page has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5075470Abstract: A process for the preparation of .mu.-3-carbopentazane-N.sup.1, N.sup.4 :N.sup.2, N.sup.5 -bis-[bis(triphenylphosphine)rhodium (I)] dinitrate by the reaction of tris(triphenylphosphine)nitratorhodium (I) with hydrazine in degassed methanol under an inert atmosphere.Type: GrantFiled: July 26, 1990Date of Patent: December 24, 1991Assignee: Plurichemie AnstaltInventors: William Heggie, Philip R. Page, Ivan Villax, Indira Ghatak, Michael B. Hursthouse
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Patent number: 5026693Abstract: Novel esters of 9.alpha.-fluoro- and chloro-corticosteroids of the formula ##STR1## wherein Y is chlorine or OR.sub.1, R.sub.1 and R.sub.2 represent an acyl group of 2-6 carbon atoms or a benzoyl group and where R.sub.1 and R.sub.2 can be the same or different in the same molecule, R.sub.3 is methyl or fluorine in either the .alpha.- or .beta.- orientation, X is chlorine or fluorine, and the C.sub.1 C.sub.2 bond can be saturated or not, especially those compounds of the formula ##STR2## wherein Y and R.sub.2 have the significance given above, are prepared by reacting the respective 9.beta.,11.beta.-epoxy compounds with hydrogen fluoride or chloride.Type: GrantFiled: May 21, 1990Date of Patent: June 25, 1991Assignee: Hovione Inter Ltd.Inventors: Ivan Villax, William Heggie, Philip R. Page
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Patent number: 4968654Abstract: The present invention refers to the compounds (.mu.-hydrazine-N.sup.1 :N.sup.2)-bis[bis(triphenylphosphine)-chlororhodium (I)] and di(.mu.-hydrazine-N.sup.1 :N.sup.2)-bis[bis(triphenylphosphine)rhodium (I)] dichloride, which are homogenous hydrogenation catalysts and their application in the hydrogenation of the exocyclic methylene group of acid addition salts of 6-demethyl-6-deoxy-6-methylene-5-hydroxytetracycline (methacycline) to prepare .alpha.-6-deoxy-5-hydroxytetracycline (doxycycline).Type: GrantFiled: March 20, 1989Date of Patent: November 6, 1990Assignee: Plurichemie AnstaltInventors: William Heggie, Philip R. Page, Ivan Villax
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Patent number: 4913892Abstract: Preparation of novel solvates of beclomethasone 17,21-dipropionate, by dissolution of beclomethasone 17,21-dipropionate in an ethereal or halogenated hydrocarbon solvent and precipitation by the addition of di-isopropyl ether. These new solvates are bulk stable, in both the micronized and non-micronized forms. The micronized form is especially suitable for the preparation of stable aerosol.Type: GrantFiled: July 24, 1985Date of Patent: April 3, 1990Assignee: Hovione Inter Ltd.Inventors: Philip R. Page, William Heggie
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Patent number: 4911865Abstract: The present invention refers to complexes prepared by reacting rhodium trinitrate with a suitable hydrazine and a suitable tertiary phosphine, more specifically to the compounds di(.mu.-hydrazine-N.sup.1 :N.sup.2)-bis[bis(triphenylphosphine)rhodium (I)]dinitrate and .mu.-3-carbopentazane-N.sup.1, N.sup.4 :N.sup.2, N.sup.5 -bis[bis(triphenylphosphine)rhodium (I)]dinitrate, which are homogenous hydrogenation catalysts and their application in the hydrogenation of the exocyclic methylene group of acid addition salts of 6-demethyl-6-deoxy-6-methylene-5-hydroxytetracycline (methacycline) to prepare .alpha.-6-deoxy-5-hydroxy-tetracycline (doxycycline).Type: GrantFiled: March 13, 1989Date of Patent: March 27, 1990Assignee: Plurichemie AnstaltInventors: William Heggie, Philip R. Page, Ivan Villax, Indira Ghatak, Michael Hursthouse
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Patent number: 4877559Abstract: A homogenous hydrogenation process of preparing 6-demethyl-6-deoxy-6 methylene-5-hydroxytetracycline using a stereospecific tertiary phosphine-hydrozino-rhodium complex catalyst.Type: GrantFiled: October 27, 1986Date of Patent: October 31, 1989Assignee: Plurichenue AnstaltInventors: Philip R. Page, Ivan Villax
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Patent number: 4863639Abstract: The present invention refers to the compounds (.mu.-hydrazine-N.sup.1 :N.sup.2)-bis[bis(triphenylphosphine)-chlororhodium (I)] and di(.mu.-hydrazine-N.sup.1 :N.sup.2)-bis[bis(triphenylphosphine)rhodium (I)] dichloride, which are homogenous hydrogenation catalysts and their application in the hydrogenation of the exocyclic methylene group of acid addition salts of 6-demethyl-6-deoxy-6-methylene-5-hydroxytetracycline (methacycline) to prepare .alpha.-6-deoxy-5-hydroxytetracycline (doxycycline).Type: GrantFiled: May 15, 1987Date of Patent: September 5, 1989Assignee: Plurichemie AnstaltInventors: William Heggie, Philip R. Page, Ivan Villax, Michael Hursthouse, Richard Somerville
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Patent number: 4857235Abstract: The present invention refers to complexes prepared by reacting rhodium trinitrate with a suitable hydrazine and a suitable tertiary phosphine, more specifically to the compounds di(.mu.-hydrazine-N.sup.1 :N.sup.2)-bis[bis(triphenylphosphine)rhodium (I)]dinitrate and .mu.-3-carbopentazane-N.sup.1,N.sup.4 :N.sup.2,N.sup.5 -bis[bis(triphenylphosphine)rhodium (I)]dinitrate, which are homogeneous hydrogenation catalysts and their application in the hydrogenation of the exocyclic methylene group of acid addition salts of 6-demethyl-6-deoxy-6-methylene-5-hydroxytetracycline (methacycline) to prepare .alpha.-6-deoxy-5-hydroxy-tetracycline (doxycycline).Type: GrantFiled: May 15, 1987Date of Patent: August 15, 1989Assignee: Plurichemie AnstaltInventors: William Heggie, Philip R. Page, Ivan Villax, Indira Ghatak, Michael Hursthouse
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Patent number: 4743699Abstract: A homogeneous stereospecific rhodium complex hydrogenation catalyst is prepared using a degassed organic solvent and eventually water.Type: GrantFiled: May 13, 1985Date of Patent: May 10, 1988Assignee: Plurichemie AnstaltInventors: Philip R. Page, Ivan Villax
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Patent number: 4655971Abstract: A process for the preparation of corticosteriod esters of the formula ##STR1## in which ---- signifies that a double bond can be present;X is hydrogen, chlorine or fluorine;R.sub.1 is hydrogen, fluorine, chlorine or methyl, which may be either .alpha. or .beta.;R.sub.2 is halogen, oxo or hydroxyl;or R.sub.3 is hydrogen, .alpha.-methyl or .beta.-methyl;or R.sub.2 and X jointly form an epoxide group;R.sub.4 is an acyl group of the formula RCO, in which R is one of the following(i) an alkyl group containing 1 to 16 carbon atoms, whether straight-chained, branched or cyclic;(ii) an aralkyl group of 7 to 8 carbon atoms;(iii) a phenyl group;R.sub.5 is hydroxyl or R.sub.6 ; whereR.sub.6 is hydrogen, one or two halogen atom substituents or OR.sub.7, where R.sub.Type: GrantFiled: August 16, 1984Date of Patent: April 7, 1987Assignee: Plurichemie AnstaltInventors: Philip R. Page, William Heggie
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Patent number: 4597904Abstract: A process for the preparation of .alpha.-6-deoxy-tetracyclines by the stereoselective heterogeneous hydrogenation of a 6-demethyl-6-deoxy-6-methylene-tetracycline or an acid addition salt thereof, in the presence of a tertiary phosphine, or the simultaneous dehalogenation and stereo-selective heterogeneous hydrogenation of an 11a-halo-6-demethyl-6-deoxy-6-methylene-tetracycline or an acid addition salt thereof, in the presence of a tertiary phosphine, characterized by the use of a rhodium salt catalysts, wherein the rhodium is bonded to a polysiloxane carrier, having the following formulae:Rh Cl.sub.3 [N{(CH.sub.2).sub.3 SiO.sub.3/2 }.sub.3 ].sub.10Rh Cl.sub.3 [N{(CH.sub.2).sub.3 SiO.sub.3/2 }.sub.3 ].sub.12Rh Cl.sub.3 [N{(CH.sub.2).sub.3 SiO.sub.3/2 }.sub.3 ].sub.15Rh Cl.sub.3 [HN{(CH.sub.2).sub.3 SiO.sub.3/2 }.sub.2 ].sub.4Rh Cl.sub.3 [HN{(CH.sub.2).sub.3 SiO.sub.3/2 }.sub.2 ].sub.8permitting easy recovery of the rhodium, by simple filtration.Type: GrantFiled: August 17, 1984Date of Patent: July 1, 1986Assignee: Hovione Inter Ltd.Inventor: Philip R. Page
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Patent number: 4550096Abstract: Stable homogeneous hydrogenation catalysts are prepared by reacting a rhodium salt or complex with a hydrazine in the presence or absence of a tertiary phosphine.Type: GrantFiled: January 14, 1983Date of Patent: October 29, 1985Assignee: Plurichemie AnstaltInventors: Philip R. Page, Ivan Villax
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Patent number: 4500458Abstract: An improved process for the preparation of .alpha.-6-deoxytetracyclines and more particularly to the stereo specific hydrogenation of the 6-methylene group of 6-deoxy-6-demethyl-6-methylene-5-hydroxytetracyline and of its 11a-halo-analog, is described in which the catalyst is the reaction product of a rhodium salt or a complex with a hydrazine or salt thereof.Type: GrantFiled: January 14, 1983Date of Patent: February 19, 1985Assignee: Plurichemie AnstaltInventors: Ivan Villax, Philip R. Page
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Patent number: 4343739Abstract: The 17.alpha.-monoesters and 17.alpha.,21-diesters of corticosteriods are well known and represent nowadays the most efficient group of anti-inflammatory compounds for topical application, having minimal systemic action.Type: GrantFiled: May 27, 1981Date of Patent: August 10, 1982Assignee: Plurichemie AnstaltInventors: Ivan Villax, Philip R. Page
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Patent number: RE32535Abstract: An improved process for the preparation of .alpha.-6-deoxytetracyclines and more particularly to the stereo specific hydrogenation of the 6-methylene group of 6-deoxy-6-demethyl-6-methylene-5-hydroxytetracyline and of its 11.alpha.-halo-analog, is described in which the catalyst is the reaction product of a rhodium salt or a complex with a hydrazine or salt thereof.Type: GrantFiled: May 1, 1986Date of Patent: October 27, 1987Assignee: Plurichemie AnstaltInventors: Ivan Villax, Philip R. Page