Patents by Inventor Philip Reaper

Philip Reaper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for measuring ATR inhibition mediated increases in DNA damage
    Patent number: 9791456
    Abstract: The present relates to methods for detecting DNA damage in subjects treated with an ATR inhibitor. More specifically, this invention relates to a method for measuring changes in levels of ?H2AX and/or pChk1Ser345 in, e.g., surrogate tissue cells, following ex vivo stimulation with a DNA damaging agent.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: October 17, 2017
    Assignees: Vertex Pharmaceuticals Incorporated, University of Newcastle Upon Tyne
    Inventors: Susanna Falcon, Philip Reaper, John Pollard, Nicola Curtin, Fiona Middleton, Tao Chen
  • Method for Measuring ATR Inhibition Mediated Increases in DNA Damage
    Publication number: 20150247866
    Abstract: The present relates to methods for detecting DNA damage in subjects treated with an ATR inhibitor. More specifically, this invention relates to a method for measuring changes in levels of ?H2AX and/or pChk1Ser345 in, e.g., surrogate tissue cells, following ex vivo stimulation with a DNA damaging agent.
    Type: Application
    Filed: February 27, 2015
    Publication date: September 3, 2015
    Inventors: Susanna Falcon, Philip Reaper, John Pollard, Nicola Curtin, Fiona Middleton, Tao Chen
  • Method for measuring ATR inhibition mediated increases in DNA damage
    Patent number: 8999632
    Abstract: The present relates to methods for detecting DNA damage in subjects treated with an ATR inhibitor. More specifically, this invention relates to a method for measuring changes in levels of ?H2AX and/or pChk1Ser345 in, e.g., surrogate tissue cells, following ex vivo stimulation with a DNA damaging agent.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: April 7, 2015
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Susanna Falcon, Philip Reaper, John Pollard, Nicola Curtin, Fiona Middleton, Tao Chen
  • Method for Measuring ATR Inhibition mediated increases in DNA damage
    Publication number: 20140134596
    Abstract: The present relates to methods for detecting DNA damage in subjects treated with an ATR inhibitor. More specifically, this invention relates to a method for measuring changes in levels of ?H2AX and/or pChk1Ser345 in, e.g., surrogate tissue cells, following ex vivo stimulation with a DNA damaging agent.
    Type: Application
    Filed: October 3, 2013
    Publication date: May 15, 2014
    Inventors: Susanna Falcon, Philip Reaper, John Pollard, Nicola Curtin, Fiona Middleton, Tao Chen
  • Methods and means for the treatment of disorders associated with cellular senescence
    Publication number: 20070099186
    Abstract: This invention relates to mechanisms of cellular senescence and, in particular, to the role of DNA repair and DNA damage checkpoint pathways in the induction and maintenance of the senescent state. Methods and means of inducing cell cycle progression in senescent cells by inhibiting DNA damage checkpoint pathways are provided herein. These methods and means provide agents and therapies for the treatment of senescent associated disorders.
    Type: Application
    Filed: April 21, 2004
    Publication date: May 3, 2007
    Inventors: Fabrizio D'Adda Di Fagagna, Philip Reaper, Stephen Jackson