Patents by Inventor Philip Richard Abraham

Philip Richard Abraham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel synthetic peptides with antimicrobial and endotoxin neutralizing properties for management of the sepsis syndrome
    Publication number: 20040049011
    Abstract: A peptide with an amino acid composition such that the peptide is amphipathic, cationic and forms a stable &agr;-helix and has the following structure comprising at least 12 amino acids
    Type: Application
    Filed: July 1, 2003
    Publication date: March 11, 2004
    Applicant: ACADEMISCH ZIEKHUIS BIJ DE UNIVERSITEIT
    Inventors: Philip Richard Abraham, Bernard Jan Appelmelk, Sander Jan Hendrik Van Deventer
  • Synthetic peptides with antimicrobial and endotoxin neutralizing properties for management of the sepsis syndrome
    Patent number: 6624140
    Abstract: A peptide with an amino acid composition such that the peptide is amphipathic, cationic and forms a stable &agr;-helix and has the following structure comprising at least 12 amino acids R1-R2-A1-B1-(A2-B2-C1-A3)m-(C2)n-R3, wherein A=an amino acid selected from the basic amino acids Lys,Arg or His B=an amino acid selected from the aromatic amino acids Phe, Trp or Tyr C=an amino acid selected from the group comprising the hydrophobic amino acids Leu, Ile, Val or Ala, and said peptide has either the orientation according to the formula or the retro orientation thereof, wherein at least 0-m of the repetitive sequence motifs (A2-B2-C1-A3) have the retro orientation and the remaining repetitive motifs (A2-B2-C1-A3) have the orientation as presented in the formula and wherein, R1-R2- and R3 are a number of amino acids, and wherein m=1-10, preferably 2-8, more preferably 2-5 and n=1-3, a pharmaceutical composition comprising such a peptide application thereof in treatment or
    Type: Grant
    Filed: January 28, 2000
    Date of Patent: September 23, 2003
    Assignee: Academisch Ziekenhuis Bij de Universiteit van Amsterdam Academisch Medisch Centrum
    Inventors: Philip Richard Abraham, Bernard Jan Appelmelk, Sander Jan Hendrik Van Deventer