Abstract: Provided is a monoclonal antibody, or an antigen binding fragment thereof, which binds specifically to an epitope within the sequence KPGAKKDTKDSRPKL (Sequence ID No. 2) of AGR2. Such monoclonal antibodies are of prognostic and diagnostic utility in the investigation of cancer, particularly metastatic cancer. The antibodies described may also be used in prognosis or diagnosis of inflammatory diseases. Also provided are kits and solid supports comprising such antibodies, as well as the therapeutic use of antibodies of the invention.

Abstract: Provided is a monoclonal antibody, or an antigen binding fragment thereof, which binds specifically to an epitope within the sequence KPGAKKDTKDSRPKL (Sequence ID No. 2) of AGR2. Such monoclonal antibodies are of prognostic and diagnostic utility in the investigation of cancer, particularly metastatic cancer. The antibodies described may also be used in prognosis or diagnosis of inflammatory diseases. Also provided are kits and solid supports comprising such antibodies, as well as the therapeutic use of antibodies of the invention.

Abstract: A prognostic indicator for metastasis comprises an antibody directed against osteopontin.

Abstract: A prognostic indicator for metastasis comprises an antibody directed against osteopontin.

Abstract: A prognostic indicator for metastasis comprises an antibody directed against osteopontin.

Abstract: A method for configuring and operating a radio system employing the ZigBee radio standard is described. The method advantageously enables a group of radio devices which are logically linked to another radio device to respond with low latency to a message. The method comprises a group identifier being generated and issued to logically linked devices, details of which are provided in a pre-installed binding table. In operation, a radio message from a device which is logically linked to another is received by a device coordinator which then broadcasts (100) the message with the generated group identifier. Only those devices which have previously received a matching group identifier (140) respond (150) to the broadcast message. Since broadcasts are not acknowledged, a rapid system response is achieved. This is important in lighting applications where a user expects instantaneous operation of lamps at the flick of a logically linked radio light switch.

Abstract: The invention relates to a protocol for communications between networked devices. The devices are logically arranged as a hierarchy of device types including a controller device type (52) from which no other device type depends and a basic device type (54) from which a number of other device types depend. The devices implement a simple device description message of fixed length and format which includes the device type, and some devices further implement an extended device description message including additional information.

Abstract: The invention relates to bridging between networks. One network uses a composite device type with a number of sub-devices. In response to a device description query from a first network device (202) a bridge device (206) responds with a message indicating its device type as being the composite device type and the number of sub-devices being the number of devices in the second network.

Abstract: The invention relates to a protocol for communications between networked devices. The devices are logically arranged as a hierarchy of device types including a controller device type (52) from which no other device type depends and a basic device type (54) from which a number of other device types depend. The devices implement a simple device description message of fixed length and format which includes the device type, and some devices further implement an extended device description message including additional information.

Abstract: The invention relates to a protocol for communications between networked devices. The devices are logically arranged as a hierarchy of device types including a controller device type (52) from which no other device type depends and a basic device type (54) from which a number of other device types depend. The devices implement a simple device description message of fixed length and format which includes the device type, and some devices further implement an extended device description message including additional information.

Abstract: Provided is a method for screening for effective agents for the treatment of cancer which method comprises selecting a putative agent that is likely to disrupt a function mediated by a critical normal gene product, which function is required for the successful division and continued cell survival of cancer cells, and which function is not required for the successful division and continued cell survival of control cells, treating a cancer cell sample and a control cell sample with a purative agent and determining the cytotoxic effect of, and/or the growth inhibitory effect of the putative agent on these samples, and identifying an effective agent as an agent which is more cytotoxic to, and/or more inhibiting to the growth of the cancer cell sample than the control cell sample. This invention further provides an effective agent identified by this screening method and a method of treating a cancer patient with such an agent.

Abstract: A method for routing messages (80) having a short routing indicator across linked master/slave configured piconets (10,20,30). Each piconet stores a routing table (62) and at each hop a receiving master node (22) performs a reception algorithm (110) on the routing indicator, the result enabling the receiving node to identify a target node and whether that node is local to the receiving piconet or a node accessible through a piconet with which the receiving piconet is linked. In the latter instance, the receiving node performs a transmission rule (120) on the result to generate a new routing indicator which is then transmitted with the message to the identified piconet.

Abstract: The invention relates to metastasis inducing DNA's, a method of identifying such DNA's and their use in diagnosis and therapy. It includes a method of screening and recovering Met-DNA comprising the steps of: (1) transferring fragments of human DNA from malignant, metastatic cancer cells into a cell line that produces only benign, non-metastasizing tumours when injected into a syngeneic animal; (2) injecting the transformed cells into a syngeneic animal; (3) selecting those animals in which metastasizing tumours have been identified; and (4) recovering the Met-DNA therefrom.