Patents by Inventor Philip S. Low

Philip S. Low has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160287731
    Abstract: Described herein are compounds, compositions, and methods for diagnosing and/or monitoring pathogenic disease using positron emission tomography. Also described are conjugates of the formula B-L-P, wherein B is a radical of a targeting agent selected from vitamin receptor binding ligands (such as folate), PSMA binding ligands, or PSMA inhibitors; L is a divalent linker comprising aspartic acid, lysine, or arginine, and P is a radical of an imaging agent or radiotherapy agent, such as a radionuclide or radionuclide containing group, or a radical of a compound capable of binding a radionuclide, such as a metal chelating group.
    Type: Application
    Filed: November 13, 2014
    Publication date: October 6, 2016
    Inventors: Iontcho R. VLAHOV, Christopher P. LEAMON, Philip S. LOW, Garth L PARHAM, Qingshou CHEN
  • Publication number: 20160274090
    Abstract: The invention relates to methods and compositions for the selection of patients for therapy with an anti-inflammatory drug. More particularly, the invention relates to compositions comprising folate-imaging agent conjugates for the selection of patients for therapy with an anti-inflammatory drug, and methods and uses therefor.
    Type: Application
    Filed: November 19, 2014
    Publication date: September 22, 2016
    Inventors: Philip S. Low, Lindsay E. Kelderhouse
  • Publication number: 20160207999
    Abstract: Human anti-human folate receptor beta antibodies and antigen-binding fragments thereof are described, as well as methods of using such antibodies and fragments to treat inflammatory disorders or cancers expressing cell surface FR?.
    Type: Application
    Filed: April 8, 2016
    Publication date: July 21, 2016
    Applicants: PURDUE RESEARCH FOUNDATION, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVI
    Inventors: Philip S. LOW, Dimiter S. DIMITROV, Yang FENG, Jiayin SHEN
  • Publication number: 20160166679
    Abstract: The invention relates to a method of treating a cancer, the method comprising the steps of administering to a patient an immunogen conjugate, administering to the patient a folate conjugate comprising a folate linked to a hapten, and administering to the patient a tyrosine kinase inhibitor.
    Type: Application
    Filed: December 11, 2015
    Publication date: June 16, 2016
    Inventors: Philip S. Low, Nimalka A. Bandara
  • Patent number: 9341629
    Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: May 17, 2016
    Assignee: Purdue Research Foundation
    Inventors: Sumith A. Kularatne, Sakkarapalayam M. Mahalingam, Philip S. Low
  • Patent number: 9333270
    Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
    Type: Grant
    Filed: August 26, 2013
    Date of Patent: May 10, 2016
    Assignee: Purdue Research Foundation
    Inventors: Philip S. Low, Sumith A. Kularatne, Sakkarapalayam M. Mahalingam
  • Publication number: 20160067341
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Application
    Filed: November 23, 2015
    Publication date: March 10, 2016
    Inventors: Philip S. LOW, Sumith A. KULARATNE
  • Patent number: 9250238
    Abstract: Pathogens are detected through the use of mutation-resistant ligands.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: February 2, 2016
    Assignee: Purdue Research Foundation
    Inventors: Philip S. Low, Alexander Wei, Ronald G. Reifenberger, Youngsoon Kim, Avijit Kumar Adak, David Lyvers, Kulbhushan Durugkar, Derek Doorneweerd, Rajendra P. Bandari, Rajesh Kumar Pandey, Alexei Leonov, Walter A. Henne, Yeong E. Kim
  • Publication number: 20160011199
    Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
    Type: Application
    Filed: May 19, 2015
    Publication date: January 14, 2016
    Inventors: Sumith A. Kularatne, Sakkarapalayam M. Mahalingam, Philip S. Low
  • Patent number: 9233175
    Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods of imaging of inflammatory diseases using the compounds.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: January 12, 2016
    Assignee: Purdue Research Foundation
    Inventors: Philip S. Low, Sumith A. Kularatne, Lindsay E. Kelderhouse, Sakkarapalayam M. Mahalingam
  • Patent number: 9180215
    Abstract: Described herein are compositions and methods for diagnosing and/or monitoring pathogenic disease states using positron emission tomography, wherein the pathogenic cells uniquely express, preferentially express, or overexpress vitamin receptors. Also described herein are 18F conjugates of vitamins and vitamin receptor-binding analogs and derivatives.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: November 10, 2015
    Assignee: Purdue Research Foundation
    Inventors: Philip S. Low, Sumith A. Kularatne
  • Patent number: 9061057
    Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: June 23, 2015
    Assignee: Purdue Research Foundation
    Inventors: Sumith A. Kularatne, Sakkarapalayam M. Mahalingam, Philip S. Low
  • Publication number: 20150110798
    Abstract: Human anti-human folate receptor beta antibodies and antigen-binding fragments thereof are described, as well as methods of using such antibodies and fragments to treat inflammatory disorders or cancers expressing cell surface FR?.
    Type: Application
    Filed: October 27, 2014
    Publication date: April 23, 2015
    Inventors: Philip S. Low, Dimiter S. Dimitrov, Yang Feng, Jiayin Shen
  • Publication number: 20150050212
    Abstract: Conjugates are described herein where CCK2R targeting ligands are attached to an active moiety, such as therapeutic agent or an imaging agent, through a linker. The conjugates can be used in the detection, diagnosis, imaging and treatment of cancer.
    Type: Application
    Filed: February 22, 2013
    Publication date: February 19, 2015
    Inventors: Philip S. Low, Charity Wayua
  • Patent number: 8916167
    Abstract: The invention relates to a method of treating or monitoring/diagnosing a disease state mediated by activated macrophages. The method comprises the step of administering to a patient suffering from a macrophage mediated disease state an effective amount of a composition comprising a conjugate or complex of the general formula Ab-X where the group Ab comprises a ligand capable of binding to activated macrophages, and when the conjugate is being used for treatment of the disease state, the group X comprises an immunogen, a cytotoxin, or a compound capable of altering macrophage function, and when the conjugate is being used for monitoring/diagnosing the disease state, X comprises an imaging agent. The method is useful for treating a patient suffering from a disease selected from the group consisting of rheumatoid arthritis, ulcerative colitis, Crohn's disease, inflammation, infections, osteomyelitis, atherosclerosis, organ transplant rejection, pulmonary fibrosis, sarcoidosis, and systemic sclerosis.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: December 23, 2014
    Assignee: Purdue Research Foundation
    Inventors: Philip S. Low, Mary J. Turk
  • Patent number: 8907058
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: December 9, 2014
    Assignee: Purdue Research Foundation
    Inventors: Philip S. Low, Sumith A. Kularatne
  • Patent number: 8871206
    Abstract: Human anti-human folate receptor beta (FR?) antibodies and antigen-binding fragments thereof are described, as well as methods of using such antibodies and fragments to treat inflammatory disorders or cancers expressing cell surface FR?.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: October 28, 2014
    Assignees: Purdue Research Foundation, The United States of America, as Represented by the Secretary Department of Health and Human Services
    Inventors: Philip S. Low, Dimiter S. Dimitrov, Yang Feng, Jiayin Shen
  • Patent number: 8865128
    Abstract: A method of differentiating tumors from healthy cells in tissue is disclosed. The method includes the steps of providing a marker-folate conjugate, placing the marker-folate conjugate in contact with the tissue and viewing the tissue.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: October 21, 2014
    Assignee: Endocyte, Inc.
    Inventors: Karim N. Jallad, Michael D. Kennedy, Philip S. Low, Dor Ben-Amotz
  • Publication number: 20140309233
    Abstract: The disclosure relates to methods, compositions, and kits for treatment of parasite-mediated disease. In one embodiment, the disclosure relates to compounds, compositions, methods and kits for the treatment of malaria. In still another embodiment, the disclosure relates to a method for treating malaria comprising the use of a Syk kinase inhibitor.
    Type: Application
    Filed: December 18, 2013
    Publication date: October 16, 2014
    Applicant: HULOW, LLC
    Inventors: Philip S. Low, Francesco Michelangelo Turrini, Kristina Rose Kesely
  • Patent number: 8858914
    Abstract: A method of differentiating tumors from healthy cells in tissue is disclosed. The method includes the steps of providing a marker-folate conjugate, placing the marker-folate conjugate in contact with the tissue and viewing the tissue.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: October 14, 2014
    Assignee: Endocyte, Inc.
    Inventors: Michael D. Kennedy, Philip S. Low