Patents by Inventor Philip S. Schein

Philip S. Schein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6218377
    Abstract: The present invention provides methods of administering aminoalkyl phosphorothioate and/or aminoalkyl thiol compounds to patients in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compounds as compared with conventional intravenous administration.
    Type: Grant
    Filed: June 5, 2000
    Date of Patent: April 17, 2001
    Assignee: MedImmune Oncology Inc.
    Inventors: Martin Stogniew, Philip S. Schein
  • Patent number: 6127351
    Abstract: The present invention provides methods of administering aminoalkyl phosphorothioate and/or aminoalkyl thiol compounds to patients in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compounds as compared with conventional intravenous administration.
    Type: Grant
    Filed: February 10, 1998
    Date of Patent: October 3, 2000
    Assignee: MedImmune Oncology Inc.
    Inventors: Martin Stogniew, Philip S. Schein
  • Patent number: 6051563
    Abstract: The present invention provides methods of administering aminoalkyl phosphorothioate and/or aminoalkyl thiol compounds to patients in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compounds as compared with conventional intravenous administration.
    Type: Grant
    Filed: February 12, 1997
    Date of Patent: April 18, 2000
    Assignee: U.S. Bioscience, Inc.
    Inventors: Martin Stogniew, Philip S. Schein
  • Patent number: 5824664
    Abstract: Chronic HIV infection is treated by administering to a subject an organic thiophosphate alone or in combination with another anti-HIV or anti-AIDS drug. The organic thiophosphate is preferably WR 151327, a compound with antioxidant and free radical scavenging activities, or a functional derivative or analogue thereof. WR 151327 suppresses induction of HIV expression in chronically infected cells mediated by cytokines such as TNF.alpha. and GM-CSF. Pharmaceutical compositions comprising at least one organic thiophosphate in combination with one or more anti-HIV or anti-AIDS drugs are also disclosed.
    Type: Grant
    Filed: March 26, 1993
    Date of Patent: October 20, 1998
    Assignees: U.S. Bioscience, Inc., National Institutes of Health, The National Cancer Institute
    Inventors: Philip S. Schein, Thea Kalebic
  • Patent number: 5804571
    Abstract: S-.omega.(.omega.-aminoalkylamino)alkyl dihydrogen phosphorothioates or pharmaceutically acceptable derivatives thereof are useful in protecting a patient undergoing AZT treatment for AIDS and AIDS-related complex from the harmful side effects or reactions and toxicity of the AZT.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 8, 1998
    Assignee: U.S. Bioscience
    Inventor: Philip S. Schein
  • Patent number: 5292497
    Abstract: A method of decreasing the toxicity of chemical therapeutic agents administered in cancer chemotherapy including adminstration to a patient undergoing chemotherapy. This reduction in toxicity can be accomplished by administering an effective amount of S-3-(3-methylaminopropylamino)propyl dihydrogen phosphorothioate. Methods of inducing mucolytic activity and reducing toxicity of acetominophen overdose are also discussed. Such activities are induced through the administration of S-3-(3-methylaminopropylamino)propyl dihydrogen phosphorothioate.
    Type: Grant
    Filed: March 29, 1993
    Date of Patent: March 8, 1994
    Assignee: U.S. Bioscience, Inc.
    Inventors: Philip S. Schein, James R. Piper
  • Patent number: 4956459
    Abstract: Compounds of the formula: ##STR1## wherein each of R.sub.1 and R.sub.2 is independently selected from the group consisting of halogen, hydroxy, or mono carboxylic acid or R.sub.1 and R.sub.2 together is a multifunctional carboxylic acid residue which forms a ring with the platinum atom through two oxygens of said multifunctional carboxylic acid; R.sub.3 is a deoxy mono or disaccharide or a derivative thereof; and R.sub.4 is selected from the group consisting of hydrogen, C.sub.1-4 -alkyl, phenyl, benzyl, substituted phenyl or substituted benzyl, wherein substituents are selected from the group consisting of halogen, nitro, C.sub.1-2 -alkoxy, carboxy, carbony ester or phenyl or a pharmaceutically acceptable salt thereof are disclosed. Compositions containing these compounds and methods using these compounds are also discussed.
    Type: Grant
    Filed: January 14, 1988
    Date of Patent: September 11, 1990
    Assignee: Georgetown University
    Inventors: Abdolhossen Talebian, Dianna C. Green, Charles F. Hammer, Philip S. Schein
  • Patent number: 4946954
    Abstract: Platinum compounds useful in the treatment of cancer are disclosed. Compositions containing these compounds and methods of using the same are also discussed. Compounds having the formula ##STR1## wherein n is 0 or 1 and when n is 1 R.sub.1 is H or C.sub.1 -C.sub.4 alkyl, R is non-substituted higher alkyl or mono or disaccharide or a derivative of a mono or disaccharide,when n is O, R.sub.1 is H or C.sub.1 -C.sub.4 alkyl, R is H, halogen, non-substituted C.sub.1 -.sub.20 alkyl, aryl, arlalkyloxy, mono or disaccharide, or a derivative of a mono or disaccharide,and R.sub.2 and R.sub.3 are selected from the group consisting of hydrogen, C.sub.1.sup.-4 alkyl or R.sub.2 and R.sub.3 or R.sub.2 and R.sub.3 together are linked to adjacent carbon atoms on a four, five or six membered ring structure, or R.sub.2 and R.sub.3 together form a fused or bicyclic ring with adjacent carbon atoms, or R.sub.2 and R.sub.3 together are a substituted or unsubstituted C.sub.1-5 alkylene group; with the proviso that R and R.sub.
    Type: Grant
    Filed: January 26, 1989
    Date of Patent: August 7, 1990
    Assignee: Georgetown University
    Inventors: Abdolhossen Talebian, Dianna C. Green, Philip S. Schein
  • Patent number: 4895936
    Abstract: Platinum compounds useful in the treatment of cancer are disclosed. Compositions containing these compounds and methods of using the same are also discussed. The compound have the formula: ##STR1## wherein n is 0 or 1, R.sub.1 is selected from the group consisting of hydrogen, a mono or disaccharide or a derivative thereof linked to the nitrogen atom by a --NHCO-amide moiety, an --NHCS-- thioamide moeity or a --CO-- carbonylmoiety, R' is selected from the group consisting of hydrogen and C.sub.1-4 alkyl, and R.sub.2 and R.sub.3 are selected from the group consisting of hydrogen, C.sub.1-4 alkyl or R.sub.2 and R.sub.3 or R.sub.2 and R.sub.3 together are linked to adjacent carbon atoms on a four, five or six membered ring structure, or R.sub.2 and R.sub.3 together form a fused or bicyclic ring with adjacent carbon atoms; with the proviso that R' and R.sub.1 cannot both be hydrogen when n=o,or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 14, 1988
    Date of Patent: January 23, 1990
    Assignee: Georgetown University
    Inventors: Abdolhossen Talebian, Dianna C. Green, Philip S. Schein
  • Patent number: 4895935
    Abstract: Platinum compounds of the formulae: ##STR1## are disclosed. Compositions containing these compounds and methods of using the same in the treatment of tumors are also discussed.
    Type: Grant
    Filed: January 14, 1988
    Date of Patent: January 23, 1990
    Assignee: Georgetown University
    Inventors: Abdolhossen Talebian, Dianna C. Green, Charles F. Hammer, Philip S. Schein
  • Patent number: 4720543
    Abstract: This invention discloses 1a- and 7-substituted derivatives of mitosanes containing thiocarbamoyl and glycosyl residues. The compounds possess antibacterial and antitumor activity, with a concomitant reduction in bone marrow toxicity as compared to the parent compounds.
    Type: Grant
    Filed: June 6, 1985
    Date of Patent: January 19, 1988
    Assignee: Georgetown University
    Inventors: Eugene McPherson, Philip S. Schein
  • Patent number: 4656159
    Abstract: Compounds of the formula ##STR1## wherein X is halogen; each R independently represents H, a C.sub.1 -C.sub.4 alkyl group, a C.sub.2 -C.sub.4 alkanoyl group, a phosphate group, or a sulfate, sulfonate, or benzoate group with the proviso that no more than one sulfate, sulfonate, or benzoate group is present in said compound; and R' represents R or a carbohydrate residue derived from a carbohydrate having the formula R'OH with the proviso that R' and the R on C-2 or both R groups on C-3 and C-4 together can represent an isopropylidene group; or a pharmaceutically acceptable salt thereof, are disclosed along with methods of synthesizing and using these compounds.
    Type: Grant
    Filed: October 31, 1984
    Date of Patent: April 7, 1987
    Assignee: Georgetown University
    Inventors: Eugene McPherson, Philip S. Schein
  • Patent number: 4419348
    Abstract: Anthracycline glycoside antibiotics are complexed with cardiolipin and then encapsulated in liposomes to reduce mammalian cardiac tissue uptake of the anthracycline glycoside and to thereby reduce the deleterious effect of such cardiac tissue uptake. The invention is directed to the composition, preparation and use of the encapsulated complex of anthracycline glycoside.
    Type: Grant
    Filed: April 27, 1981
    Date of Patent: December 6, 1983
    Assignee: Georgetown University
    Inventors: Aquilur Rahman, Philip S. Schein