Patents by Inventor Philip S. Schein
Philip S. Schein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230174562Abstract: The present disclosure relates to prodrugs, double prodrugs, derivatives and analogues of 3-(methylamino)-2-((methy-lamino)methyl)propane-1-thiol. Their use as radio- and chemo-protectors is also described.Type: ApplicationFiled: May 7, 2021Publication date: June 8, 2023Inventors: Philip S. Schein, Darryl C. Rideout
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Publication number: 20230138150Abstract: The present disclosure relates to prodrugs, double prodrugs, derivatives and analogues of 3-(methylamino)-2-((methylamino)methyl)propane-1-thiol. The compounds of this disclosure also relate to formula I: The use of these compounds as radio- and chemo-protectors is also described.Type: ApplicationFiled: November 21, 2022Publication date: May 4, 2023Inventors: Philip S. Schein, Darryl C. Rideout
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Patent number: 11566032Abstract: The present disclosure relates to prodrugs, double prodrugs, derivatives and analogues of 3-(methylamino)-2-((methylamino)methyl)propane-1-thiol. The compounds of this disclosure also relate to The use of these compounds as radio— and chemo—protectors is also described.Type: GrantFiled: May 7, 2021Date of Patent: January 31, 2023Assignees: TONIX PHARMACEUTICALS, INC., TONIX PHARMACEUTICALS HOLDING CORP.Inventors: Philip S. Schein, Darryl C. Rideout
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Publication number: 20210388011Abstract: The present disclosure relates to prodrugs, double prodrugs, derivatives and analogues of 3-(methylamino)-2-((methylamino)methyl)propane-1-thiol. Their use as radio- and chemo-protectors is also described.Type: ApplicationFiled: May 7, 2021Publication date: December 16, 2021Inventors: Philip S. Schein, Darryl C. Rideout
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Patent number: 6218377Abstract: The present invention provides methods of administering aminoalkyl phosphorothioate and/or aminoalkyl thiol compounds to patients in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compounds as compared with conventional intravenous administration.Type: GrantFiled: June 5, 2000Date of Patent: April 17, 2001Assignee: MedImmune Oncology Inc.Inventors: Martin Stogniew, Philip S. Schein
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Patent number: 6127351Abstract: The present invention provides methods of administering aminoalkyl phosphorothioate and/or aminoalkyl thiol compounds to patients in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compounds as compared with conventional intravenous administration.Type: GrantFiled: February 10, 1998Date of Patent: October 3, 2000Assignee: MedImmune Oncology Inc.Inventors: Martin Stogniew, Philip S. Schein
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Patent number: 6051563Abstract: The present invention provides methods of administering aminoalkyl phosphorothioate and/or aminoalkyl thiol compounds to patients in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compounds as compared with conventional intravenous administration.Type: GrantFiled: February 12, 1997Date of Patent: April 18, 2000Assignee: U.S. Bioscience, Inc.Inventors: Martin Stogniew, Philip S. Schein
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Patent number: 5824664Abstract: Chronic HIV infection is treated by administering to a subject an organic thiophosphate alone or in combination with another anti-HIV or anti-AIDS drug. The organic thiophosphate is preferably WR 151327, a compound with antioxidant and free radical scavenging activities, or a functional derivative or analogue thereof. WR 151327 suppresses induction of HIV expression in chronically infected cells mediated by cytokines such as TNF.alpha. and GM-CSF. Pharmaceutical compositions comprising at least one organic thiophosphate in combination with one or more anti-HIV or anti-AIDS drugs are also disclosed.Type: GrantFiled: March 26, 1993Date of Patent: October 20, 1998Assignees: U.S. Bioscience, Inc., National Institutes of Health, The National Cancer InstituteInventors: Philip S. Schein, Thea Kalebic
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Patent number: 5804571Abstract: S-.omega.(.omega.-aminoalkylamino)alkyl dihydrogen phosphorothioates or pharmaceutically acceptable derivatives thereof are useful in protecting a patient undergoing AZT treatment for AIDS and AIDS-related complex from the harmful side effects or reactions and toxicity of the AZT.Type: GrantFiled: June 7, 1995Date of Patent: September 8, 1998Assignee: U.S. BioscienceInventor: Philip S. Schein
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Patent number: 5292497Abstract: A method of decreasing the toxicity of chemical therapeutic agents administered in cancer chemotherapy including adminstration to a patient undergoing chemotherapy. This reduction in toxicity can be accomplished by administering an effective amount of S-3-(3-methylaminopropylamino)propyl dihydrogen phosphorothioate. Methods of inducing mucolytic activity and reducing toxicity of acetominophen overdose are also discussed. Such activities are induced through the administration of S-3-(3-methylaminopropylamino)propyl dihydrogen phosphorothioate.Type: GrantFiled: March 29, 1993Date of Patent: March 8, 1994Assignee: U.S. Bioscience, Inc.Inventors: Philip S. Schein, James R. Piper
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Patent number: 4956459Abstract: Compounds of the formula: ##STR1## wherein each of R.sub.1 and R.sub.2 is independently selected from the group consisting of halogen, hydroxy, or mono carboxylic acid or R.sub.1 and R.sub.2 together is a multifunctional carboxylic acid residue which forms a ring with the platinum atom through two oxygens of said multifunctional carboxylic acid; R.sub.3 is a deoxy mono or disaccharide or a derivative thereof; and R.sub.4 is selected from the group consisting of hydrogen, C.sub.1-4 -alkyl, phenyl, benzyl, substituted phenyl or substituted benzyl, wherein substituents are selected from the group consisting of halogen, nitro, C.sub.1-2 -alkoxy, carboxy, carbony ester or phenyl or a pharmaceutically acceptable salt thereof are disclosed. Compositions containing these compounds and methods using these compounds are also discussed.Type: GrantFiled: January 14, 1988Date of Patent: September 11, 1990Assignee: Georgetown UniversityInventors: Abdolhossen Talebian, Dianna C. Green, Charles F. Hammer, Philip S. Schein
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Patent number: 4946954Abstract: Platinum compounds useful in the treatment of cancer are disclosed. Compositions containing these compounds and methods of using the same are also discussed. Compounds having the formula ##STR1## wherein n is 0 or 1 and when n is 1 R.sub.1 is H or C.sub.1 -C.sub.4 alkyl, R is non-substituted higher alkyl or mono or disaccharide or a derivative of a mono or disaccharide,when n is O, R.sub.1 is H or C.sub.1 -C.sub.4 alkyl, R is H, halogen, non-substituted C.sub.1 -.sub.20 alkyl, aryl, arlalkyloxy, mono or disaccharide, or a derivative of a mono or disaccharide,and R.sub.2 and R.sub.3 are selected from the group consisting of hydrogen, C.sub.1.sup.-4 alkyl or R.sub.2 and R.sub.3 or R.sub.2 and R.sub.3 together are linked to adjacent carbon atoms on a four, five or six membered ring structure, or R.sub.2 and R.sub.3 together form a fused or bicyclic ring with adjacent carbon atoms, or R.sub.2 and R.sub.3 together are a substituted or unsubstituted C.sub.1-5 alkylene group; with the proviso that R and R.sub.Type: GrantFiled: January 26, 1989Date of Patent: August 7, 1990Assignee: Georgetown UniversityInventors: Abdolhossen Talebian, Dianna C. Green, Philip S. Schein
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Patent number: 4895935Abstract: Platinum compounds of the formulae: ##STR1## are disclosed. Compositions containing these compounds and methods of using the same in the treatment of tumors are also discussed.Type: GrantFiled: January 14, 1988Date of Patent: January 23, 1990Assignee: Georgetown UniversityInventors: Abdolhossen Talebian, Dianna C. Green, Charles F. Hammer, Philip S. Schein
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Patent number: 4895936Abstract: Platinum compounds useful in the treatment of cancer are disclosed. Compositions containing these compounds and methods of using the same are also discussed. The compound have the formula: ##STR1## wherein n is 0 or 1, R.sub.1 is selected from the group consisting of hydrogen, a mono or disaccharide or a derivative thereof linked to the nitrogen atom by a --NHCO-amide moiety, an --NHCS-- thioamide moeity or a --CO-- carbonylmoiety, R' is selected from the group consisting of hydrogen and C.sub.1-4 alkyl, and R.sub.2 and R.sub.3 are selected from the group consisting of hydrogen, C.sub.1-4 alkyl or R.sub.2 and R.sub.3 or R.sub.2 and R.sub.3 together are linked to adjacent carbon atoms on a four, five or six membered ring structure, or R.sub.2 and R.sub.3 together form a fused or bicyclic ring with adjacent carbon atoms; with the proviso that R' and R.sub.1 cannot both be hydrogen when n=o,or a pharmaceutically acceptable salt thereof.Type: GrantFiled: January 14, 1988Date of Patent: January 23, 1990Assignee: Georgetown UniversityInventors: Abdolhossen Talebian, Dianna C. Green, Philip S. Schein
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Patent number: 4720543Abstract: This invention discloses 1a- and 7-substituted derivatives of mitosanes containing thiocarbamoyl and glycosyl residues. The compounds possess antibacterial and antitumor activity, with a concomitant reduction in bone marrow toxicity as compared to the parent compounds.Type: GrantFiled: June 6, 1985Date of Patent: January 19, 1988Assignee: Georgetown UniversityInventors: Eugene McPherson, Philip S. Schein
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Patent number: 4656159Abstract: Compounds of the formula ##STR1## wherein X is halogen; each R independently represents H, a C.sub.1 -C.sub.4 alkyl group, a C.sub.2 -C.sub.4 alkanoyl group, a phosphate group, or a sulfate, sulfonate, or benzoate group with the proviso that no more than one sulfate, sulfonate, or benzoate group is present in said compound; and R' represents R or a carbohydrate residue derived from a carbohydrate having the formula R'OH with the proviso that R' and the R on C-2 or both R groups on C-3 and C-4 together can represent an isopropylidene group; or a pharmaceutically acceptable salt thereof, are disclosed along with methods of synthesizing and using these compounds.Type: GrantFiled: October 31, 1984Date of Patent: April 7, 1987Assignee: Georgetown UniversityInventors: Eugene McPherson, Philip S. Schein
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Patent number: 4419348Abstract: Anthracycline glycoside antibiotics are complexed with cardiolipin and then encapsulated in liposomes to reduce mammalian cardiac tissue uptake of the anthracycline glycoside and to thereby reduce the deleterious effect of such cardiac tissue uptake. The invention is directed to the composition, preparation and use of the encapsulated complex of anthracycline glycoside.Type: GrantFiled: April 27, 1981Date of Patent: December 6, 1983Assignee: Georgetown UniversityInventors: Aquilur Rahman, Philip S. Schein