Patents by Inventor Philip Stewart Low

Philip Stewart Low has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Folate Receptor Binding Conjugates of Antifolates
    Publication number: 20200147072
    Abstract: Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating such diseases are also described.
    Type: Application
    Filed: June 13, 2019
    Publication date: May 14, 2020
    Applicants: Purdue Research Foundation, Endocyte, Inc.
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Philip Stewart Low
  • PSMA binding ligand-linker conjugates and methods for using
    Patent number: 10557128
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Grant
    Filed: March 24, 2018
    Date of Patent: February 11, 2020
    Assignee: Purdue Research Foundation
    Inventors: Philip Stewart Low, Venkatesh Chelvam, Youngsoon Kim, Sumith A. Kularatne
  • COMPOSITIONS AND METHODS FOR CAR T CELL THERAPY
    Publication number: 20200023009
    Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
    Type: Application
    Filed: February 28, 2018
    Publication date: January 23, 2020
    Inventors: Philip Stewart LOW, Haiyan CHU, Yong Gu LEE, Yingjuan J. LU, Christopher Paul LEAMON, Leroy W. WHEELER, II
  • LUTEINIZING HORMONE-RELEASING HORMONE RECEPTOR (LHRH-R) CONJUGATES AND USES THEREOF
    Publication number: 20190365904
    Abstract: The present teachings relate generally to conjugates and methods for imaging a tumor microenvironment in a patient, and to conjugates and methods for treating LHRH-R expressing cancer in a patient. The present teachings relate generally to method of making conjugates comprising an LHRH-R antagonist.
    Type: Application
    Filed: December 13, 2017
    Publication date: December 5, 2019
    Inventors: Philip Stewart LOW, Jyoti ROY
  • LIGAND IONOPHORE CONJUGATES
    Publication number: 20190298843
    Abstract: The invention described herein pertains to ligand-ionophore conjugates, that may also comprise a linked therapeutic agent or imaging agent, and pharmaceutical compositions containing the conjugates. Also described are methods of using the conjugates for increasing the endosomal accumulation and escape of a therapeutic agent, or an imaging agent.
    Type: Application
    Filed: May 16, 2019
    Publication date: October 3, 2019
    Inventors: Philip Stewart LOW, Andrea L. KASINSKI, Loganathan RANGASAMY, Venkatesh CHELVAM
  • Ligand ionophore conjugates
    Patent number: 10406238
    Abstract: The invention described herein pertains to ligand-ionophore conjugates, that may also comprise a linked therapeutic agent or imaging agent, and pharmaceutical compositions containing the conjugates. Also described are methods of using the conjugates for increasing the endosomal accumulation and escape of a therapeutic agent, or an imaging agent.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: September 10, 2019
    Assignee: Purdue Research Foundation
    Inventors: Philip Stewart Low, Venkatesh Chelvam
  • METHODS OF USE FOR CAR T CELLS
    Publication number: 20190255109
    Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells wherein the CAR T cells comprise a CAR and the CAR comprises an E2 anti-fluorescein antibody fragment, and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
    Type: Application
    Filed: January 22, 2019
    Publication date: August 22, 2019
    Inventors: Philip Stewart LOW, Haiyan CHU, Yingjuan June LU, Christopher Paul LEAMON, Leroy W. WHEELER, II, Michael C. JENSEN, James MATTHAEI
  • Folate receptor binding conjugates of antifolates
    Patent number: 10363250
    Abstract: Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating stroll diseases are also described.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: July 30, 2019
    Assignees: Endocyte, Inc., Purdue Research Foundation
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Philip Stewart Low
  • METHOD OF TREATING CANCER BY TARGETING MYELOID-DERIVED SUPPRESSOR CELLS
    Publication number: 20190216935
    Abstract: The invention described herein relates to methods for treating a cancer using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker. More particularly, the invention described herein relates to methods for treating a cancer using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker to target myeloid-derived suppressor cells.
    Type: Application
    Filed: May 25, 2017
    Publication date: July 18, 2019
    Inventors: Philip Stewart LOW, Bingbing WANG, Christopher Paul LEAMON, Yingjuan June LU, Leroy W. WHEELER, II
  • METHODS AND COMPOSITIONS FOR CAR T CELL THERAPY
    Publication number: 20190091308
    Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
    Type: Application
    Filed: April 7, 2017
    Publication date: March 28, 2019
    Inventors: Philip Stewart LOW, Haiyan CHU, Yong Gu LEE
  • PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING
    Publication number: 20190002861
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Application
    Filed: March 24, 2018
    Publication date: January 3, 2019
    Inventors: Philip Stewart Low, Venkatesh Chelvam, Youngsoon Kim, Sumith A. Kularatne
  • LIGAND IONOPHORE CONJUGATES
    Publication number: 20180154006
    Abstract: The invention described herein pertains to ligand-ionophore conjugates, that may also comprise a linked therapeutic agent or imaging agent, and pharmaceutical compositions containing the conjugates. Also described are methods of using the conjugates for increasing the endosomal accumulation and escape of a therapeutic agent, or an imaging agent.
    Type: Application
    Filed: May 11, 2016
    Publication date: June 7, 2018
    Inventors: Philip Stewart LOW, Venkatesh CHELVAM
  • PSMA binding ligand-linker conjugates and methods for using
    Patent number: 9951324
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: April 24, 2018
    Assignee: Purdue Research Foundation
    Inventors: Philip Stewart Low, Venkatesh Chelvam, Youngsoon Kim, Sumith A. Kularatne
  • METHODS OF TREATING CANCER BY TARGETING TUMOR-ASSOCIATED MACROPHAGES
    Publication number: 20170266303
    Abstract: Methods for treating cancers using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker are described. Methods for treating cancers using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker to target tumor associated macrophages are described.
    Type: Application
    Filed: November 24, 2015
    Publication date: September 21, 2017
    Inventors: Yingjuan J. LU, Leroy W. WHEELER, II, Philip Stewart LOW, Christopher Paul LEAMON
  • Folate Receptor Binding Conjugates of Antifolates
    Publication number: 20170246314
    Abstract: Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating stroll diseases are also described.
    Type: Application
    Filed: December 13, 2016
    Publication date: August 31, 2017
    Applicants: Purdue Research Foundation, Endocyte, Inc.
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Philip Stewart Low
  • Folate receptor alpha binding ligands
    Patent number: 9629918
    Abstract: The invention described herein pertains to targeted drug delivery conjugates comprising folate receptor ? (FR-?) selective binding ligands and methods for diagnosing, monitoring, and eliminating pathological cells that express FR-?.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: April 25, 2017
    Assignee: Purdue Research Foundation
    Inventors: Philip Stewart Low, Balasubramanian Vaitilingam, Venkatesh Chelvam
  • Folate receptor binding conjugates of antifolates
    Patent number: 9549992
    Abstract: Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating such diseases are also described.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: January 24, 2017
    Assignees: Purdue Research Foundation, Endocyte, Inc.
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Philip Stewart Low
  • Folate Receptor Binding Conjugates of Antifolates
    Publication number: 20160263237
    Abstract: Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating such diseases are also described.
    Type: Application
    Filed: October 21, 2015
    Publication date: September 15, 2016
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Philip Stewart Low
  • PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING
    Publication number: 20160151508
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Application
    Filed: February 8, 2016
    Publication date: June 2, 2016
    Inventors: Philip Stewart Low, Venkatesh Chelvam, Youngsoon Kim, Sumith A. Kularatne
  • Ex vivo flow cytometry method and device
    Patent number: 9279813
    Abstract: The invention relates to a method for diagnosing a disease state mediated by pathogenic cells. The method comprises the steps of combining with an ex vivo patient sample a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using flow cytometry.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: March 8, 2016
    Assignee: Purdue Research Foundation
    Inventors: Philip Stewart Low, Wei He, Sumith A. Kularatne