Abstract: This provides an improved process for making a flexible, porous, dissolvable solid sheet article with improved pore structures.

Abstract: An attachment device for interconnecting a canopy to a modular floating platform includes an elongate first mounting plate defining a distal opening for receiving a first fastener for attaching the first mounting plate to the modular floating platform and an attachment opening for receiving a second fastener for attaching a leg of the canopy to the first mounting plate and a second mounting plate attached to the first mounting plate such that the second mounting plate extends substantially perpendicular to the first mounting plate. A system includes such an attachment device, a modular floating platform, and a canopy, with the attachment device interconnecting the canopy to the modular floating platform.

Abstract: Provided herein are compounds of Formula (I) that are dual inhibitors of kinases and bromo-domain proteins. The disclosure also relates to pharmaceutical compositions containing such compounds, methods for using such compounds in the treatment of cancers, particularly, the treatment of multiple myeloma cancers, and to related uses.

Abstract: The present invention relates to compounds of formula I bearing a sulfoxoniumylide moiety as warhead, or salts thereof. Such compounds can be used as activity-based probes for cysteine proteases such as cathepsin X, in methods of detecting cysteine protease activity and in related diagnostic or therapeutic methods.

Abstract: The present disclosure relates generally, but not exclusively, to compounds and their use in therapy, to compositions and agents comprising said compounds, to methods of treatment using said compounds, and their use in the manufacture of medicaments. The disclosure further relates to inhibitors of IRAP and their use in the treatment or prevention of Alzheimer's disease and the treatment and prevention of memory and cognitive disorders.

Abstract: Systems and methods designed to capture and utilize the context of a patient's visit along with a general categorization of their personality for the purpose of identifying actions to a healthcare provider for use during the specific patient visit. The actions are intended to be used by the healthcare provider to improve the patient's overall satisfaction with their care and specifically their reported satisfaction on various patient satisfaction feedback surveys. The systems and methods also can serve to improve future patient visits through better understanding, better engagement, improved trust, and better overall experience with healthcare providers.

Abstract: To allow user customisation, this shoe invention provides; 1. Interchangeable components of the shoe as shown in FIG. 1. The Shoe Sole (13) and the Shoe Upper (10). 2. Adjustable Nose Cone device, “the raiser” (14), as shown in FIG. 6. Provides further customisation allowing the Nose Cone (15) of the Shoe to be adjustable. The interchangeable Shoe design and adjustable Nose Cone device described in this patent allows users to achieve interchangeability and customisation without eliminating functionality. 1. The interchangeable Shoe design, as shown in FIG. 1. Comprises of the Shoe Sole (13) and the Shoe Upper (10). Both Components are joined together in an independent and interchangeable way by means of two layers of hook and loop material strips affixed to the respective components i.e. the Shoe Sole (13) and the Shoe Upper (10). 2. The adjustable Nose Cone (15) as shown in FIG. 1. comprises of a device called, “the raiser” (14). FIG. 6. Provides further details and views of “the raiser”.

Abstract: A system, a method, and an apparatus to retain an in-cylinder linear position sensor in a cavity of a housing of a hydraulic cylinder assembly are described. The in-cylinder linear position sensor includes a sensor body that houses circuitry of the in-cylinder linear position sensor, and a sensor cap that extends from an upper surface of the sensor body. The sensor cap has a retention mechanism with a portion that extends radially outward relative to a central vertical axis of the sensor body so as to extend into and engage a wall of an access port of the housing to hold the in-cylinder linear position sensor in the cavity of the housing. The portion of the retention mechanism is configured to move inward from an outer position toward the central vertical axis of the sensor body.

Abstract: The present invention relates to antimicrobial compounds and their uses, and in particular to peptide antibiotics which may be used in the treatment of bacterial infections such as Gram-negative bacterial infections, particularly those caused by multidrug-resistant (MDR) pathogens.

Abstract: The present disclosure relates generally, but not exclusively, to compounds and their use in therapy, to compositions and agents comprising said compounds, to methods of treatment using said compounds, and their use in the manufacture of medicaments. The disclosure further relates to inhibitors of IRAP and their use in the treatment or prevention of Alzheimer's disease and the treatment and prevention of memory and cognitive disorders.

Abstract: A system, a method, and an apparatus to retain an in-cylinder linear position sensor in a cavity of a housing of a hydraulic cylinder assembly are described. The in-cylinder linear position sensor includes a sensor body that houses circuitry of the in-cylinder linear position sensor, and a sensor cap that extends from an upper surface of the sensor body. The sensor cap has a retention mechanism with a portion that extends radially outward relative to a central vertical axis of the sensor body so as to extend into and engage a wall of an access port of the housing to hold the in-cylinder linear position sensor in the cavity of the housing. The portion of the retention mechanism is configured to move inward from an outer position toward the central vertical axis of the sensor body.

Abstract: The present invention relates to antimicrobial compounds and their uses, and in particular to peptide antibiotics which may be used in the treatment of bacterial infections such as Gram-negative bacterial infections, particularly those caused by multidrug-resistant (MDR) pathogens.

Abstract: An ergonomic case for a smartphone features contoured finger grips at appropriate locations around the outside surface, in a pattern that provides a comfortable and ergonomic grip for a hand. Specifically, three or four finger indentations are provided in the position of use in voice calling mode. The finger indentations may be located on either side, depending on whether the particular embodiment is intended for right or left-handed users. An additional thumb indentation may optionally be provided on the opposite side. The finger indentations and thumb indentations are used to hold the smartphone, to provide a more comfortable and secure grip for the fingers, and may include ridges or another high-friction surface in the indentations.

Abstract: A system and process for recovering copper from a copper-containing ore, concentrate, or other copper-bearing material to produce high quality cathode copper from a leach solution without the use of copper solvent/solution extraction techniques or apparatus. A process for recovering copper from a copper-containing ore generally includes the steps of providing a feed stream containing comminuted copper-containing ore, concentrate, or other copper-bearing material, leaching the feed stream to yield a copper-containing solution, conditioning the copper-containing solution through one or more physical or chemical conditioning steps, and electrowinning copper directly from the copper-containing solution in multiple electrowinning stages, without subjecting the copper-containing solution to solvent/solution extraction prior to electrowinning.

Abstract: The present invention relates to selective inhibitors of phosphoinositide (PI) 3-kinase ?, use of the selective inhibitors in anti-thrombotic therapy, and a method for screening compounds useful for the new anti-thrombotic therapy by detecting selective inhibitory activity of PI 3-kinase ? of the compound. The invention also relates to novel compounds that are inhibitors of PI 3-kinase.

Abstract: A system and process for recovering copper from a copper-containing ore, concentrate, or other copper-bearing material to produce high quality cathode copper from a leach solution without the use of copper solvent/solution extraction techniques or apparatus. A process for recovering copper from a copper-containing ore generally includes the steps of providing a feed stream containing comminuted copper-containing ore, concentrate, or other copper-bearing material, leaching the feed stream to yield a copper-containing solution, conditioning the copper-containing solution through one or more physical or chemical conditioning steps, and electrowinning copper directly from the copper-containing solution in multiple electrowinning stages, without subjecting the copper-containing solution to solvent/solution extraction prior to electrowinning.

Abstract: The present invention relates generally to a process for recovering copper and/or other metal values from a metal-bearing ore, concentrate, or other metal-bearing material using pressure leaching and direct electrowinning. More particularly, the present invention relates to a substantially acid-autogenous process for recovering copper from chalcopyrite-containing ore using pressure leaching and direct electrowinning in combination with a leaching, solvent/solution extraction and electrowinning operation.

Abstract: A system and process for recovering copper from a copper-containing ore, concentrate, or other copper-bearing material to produce high quality cathode copper from a leach solution without the use of copper solvent/solution extraction techniques or apparatus. A process for recovering copper from a copper-containing ore generally includes the steps of providing a feed stream containing comminuted copper-containing ore, concentrate, or other copper-bearing material, leaching the feed stream to yield a copper-containing solution, conditioning the copper-containing solution through one or more physical or chemical conditioning steps, and electrowinning copper directly from the copper-containing solution in multiple electrowinning stages, without subjecting the copper-containing solution to solvent/solution extraction prior to electrowinning.

Abstract: The present invention relates to antimicrobial compounds and their uses, and in particular to peptide antibiotics which may be used in the treatment of bacterial infections such as Gram-negative bacterial infections, particularly those caused by multidrug-resistant (MDR) pathogens.