Abstract: Provided herein are methods of treating and/or managing cancers, which comprise administering to a patient Compound A. Provided herein are also methods of treating and/or managing cancers, which comprise administering to a patient Compound A in combination with nivolumab. Additionally, provided herein are methods of treating and/or managing cancers, which comprise administering to a patient Compound A in combination with chemotherapy.

Abstract: A configurable apparatus for vertical food roasting has a fixed centered anchor to support a removeable vertical pole or a removable vertical food skewer. Top section of vertical pole further supports interchangeable food hooks. When interchangeable food hooks are engaged, a variety of food items could be attached and cooked vertically above the surface of the configurable apparatus. Alternatively, when the removable vertical food skewer frame member is engaged, a removeable horizontal food grill could be installed onto the fixed centered anchor. Food items could be stacked in a vertical formation on the horizontal food grill and cooked in vertical fashion. High side wall of roasting apparatus catches all oil drips, and wide handles on either side of side wall allows for safe and stable movement and transfer of hot oil drips and roasted hot food items while they are engaged onto interchangeable food hook or vertical food skewer.

Abstract: A method for preparing a complex comprising a radioisotope of gallium for use in radiotherapy or in a medical imaging procedure, said method comprising adding a gallium radioisotope solution obtained directly from a gallium radionuclide generator to a composition comprising a pharmaceutically acceptable buffer and optionally also a pharmaceutically acceptable basic reagent, in amounts sufficient to increase the pH to a level in the range of 3 to 8, wherein the composition further comprises a chelator that is able to chelate radioactive gallium within said pH range and at moderate temperature, said chelator being optionally linked to a biological targeting agent. Kits and compositions for use in the method are also described and claimed.

Abstract: Fabric and home care compositions including a surfactant and a protease. The automatic dishwashing composition is in the form of a water-soluble unit-dose pouch including a compartment. The compartment includes both a powder component and a gel component. The protease is a subtilisin variant that includes: (i) a mutation at position 122; and (ii) one or more mutations at positions 126, 127, 128, 211 and 212, with reference to SEQ ID NO: 1. The variant has at least about 80% identity to the amino acid sequence of SEQ ID NO: 1.

Abstract: A battery-powered tool equipped with damping to reduce vibration, noise and heat generated by drive components and high oscillation rates of components and mating accessories mounted to those tools. Some versions of the tool may include elastomeric damping pads, rings, strips, blocks, threaded mounts or co-molded elements. Other versions may include shrouded components or shrouds comprising elastomeric materials.

Abstract: A transmission for a power train of a vehicle, the transmission including an input shaft, a first output shaft, and a second output shaft, where the first output shaft is received at least partially within the second output shaft, and where the first and second output shafts are rotatable. The transmission further includes a differential operatively arranged between the input shaft and the first and second output shafts, where the differential is configured to divide drive power applied at the input shaft onto the first and second output shafts. Moreover, the transmission includes a stationary component. Additionally, the transmission includes a cover between the second output shaft and the stationary component, where the cover defines at least one duct for guiding lubricant, with the at least one duct extending substantially radially.

Abstract: Excessive deposition of extracellular matrix is a hallmark of Idiopathic pulmonary fibrosis (IPF); it is advantageous to target the cells and the mechanisms associated with this process. By targeting myofibroblasts (specialized contractile fibroblasts) that are key for the development of IPF with drugs conjugated with fibroblast activation protein (FAP), this technology helps minimize the production of extracellular matrix in the lungs and provides a new treatment option for patients diagnosed with IPF.

Abstract: Embodiments disclosed are directed to ensuring resource compliance within a cloud-based environment. The embodiments include steps for performing both pre-provisioning and post-provisioning checks of resources, such as network protocols, prior to and after their deployment within the cloud-based environment. These steps include using bitemporal analysis to determine the impact of deploying resources within the environment through the use of multiple execution timelines where the impact of deploying a resource may be evaluated on an alternative timeline that does not change the current resource scope of the cloud-based environment. The analysis may further include tracking the impact of the resource after it has been deployed to ensure resource compliance.

Abstract: The present disclosure relates to delivering a biological material to a wounded tissue of a patient by the application of a composition comprising biocompatible modified starch particles modified by carboxylation or hydroxylation of glucose units in the starch. Compositions comprising biocompatible modified starch particles are also provided.

Abstract: The present disclosure relates to V and F-codoped cobalt hydroxide nanowires electrocatalysts V—Co(OH)2 comprises vanadium (V) at less stable 4+ oxidation state and fluoride (F) ions codoped directly on carbon cloth electrode. The V—Co(OH)2 produces excellent oxygen evolution reaction (OER) activity in alkaline conditions. The present disclosure also relates to a method of fabrication of the V and F-codoped cobalt hydroxide nanowires electrocatalysts V—Co(OH)2 comprising vanadium (V) at less stable 4+ oxidation state and fluoride (F) ions codoped directly on carbon cloth electrode by hydrothermal reaction.

Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

Abstract: In one embodiment, a method for a process facility is disclosed. The method includes identifying a plurality of moving entities and a plurality of movable parts associated with the process facility. The method further includes determining an action event for each of at least some interactions between one or more of the plurality of moving entities and one or more of the plurality of movable parts, where one or more of the at least some interactions include a manipulation of at least one of the plurality of movables parts by at least one of the plurality of moving entities. Moreover, the method includes determining an actual duration for each of at least some of the action events. Additionally, the method includes tracking the actual duration for each of at least some of the action events in relation to an expected duration of each action event.

Abstract: The present invention relates to compounds that bind to prostate-specific membrane antigen (PSMA) comprising a PSMA binding moiety, a linker group comprising a silicon-fluoride acceptor (SIFA) moiety and a chelator moiety, optionally containing a chelated nonradioactive or radioactive cation, wherein the SIFA moiety comprises a covalent bond between a silicon and a fluorine atom which can be 18F. The disclosure includes compounds of Formula (1) or a pharmaceutically acceptable salt or any individual isomer thereof, wherein CM is defined herein, and their use as cancer diagnostic or imaging agents.

Abstract: Embodiments of this disclosure provides systems and methods for displays. In embodiments, a display system includes a frame, an eyepiece coupled to the frame, and a first adhesive bond disposed between the frame and the eyepiece. The eyepiece can include a light input region and a light output region. The first adhesive bond can be disposed along a first portion of a perimeter of the eyepiece, where the first portion of the perimeter of the eyepiece borders the light input region such that the first adhesive bond is configured to maintain a position of the light input region relative to the frame.

Abstract: An attachment mechanism configured to couple to a receiving port of a bronchoscope, the attachment mechanism including an adapter segment having a tubular body having an inner lumen and distal end, where the distal end includes a plurality of axial slits positioned circumferentially around the distal end to define a flexible tab section, where the flexible tab section defined a recess within the inner lumen configured to receive and mechanically interlock with the receiving port of the bronchoscope; and a slide lock positioned over the tubular body configured to slide over the tubular body between a first position that allows flexible tab section to flex radially outward to receive the receiving port within the recess, and a second position where slide lock restrains the radial expansion of flexible tab section.

Abstract: A computer-implemented system for predictive assembly includes a model generator and a model analyzer. The model generator generates a first model of a first component and a second model of a second component before the first component and the second component are coupled together. The model analyzer analyzes the first model and the second model to determine dimensions of a space between a first mating surface of the first component and a second mating surface of the second component after the first component and the second component are coupled together.

Abstract: Apparatus and methods for charging and specifying a capacitor for storing charge in a wearable cardioverter defibrillator (“WCD”). In one aspect the WCD circuitry includes a power source such as a battery coupled to a charger that provides charge energy to an energy storage module including an energy storage capacitor having a rated voltage. Control circuitry is configured to implement a multi-stage charging scheme under which the energy storage capacitor is charged to a first intermediate voltage below its rated voltage during a first charging stage and charged to a second voltage above the rated voltage for a limited time during a second charging stage. In response to detection of potential shockable rhythms the capacitor is charged to an intermediate voltage, while upon confirmation of shockable rhythms the capacitor may be charged to the second voltage, which is then used to deliver a shock to a patient.

Abstract: Systems and methods for multi-modal image generation are provided. One or more aspects of the systems and methods includes obtaining a text prompt and layout information indicating a target location for an element of the text prompt within an image to be generated and computing a text feature map including a plurality of values corresponding to the element of the text prompt at pixel locations corresponding to the target location. Then the image is generated based on the text feature map using a diffusion model. The generated image includes the element of the text prompt at the target location.

Abstract: The invention relates to a method for a communication between a fueling device (2) and a vehicle (4), having the steps of coupling the fueling device to a tank (6) of the vehicle by means of a fuel hose (10), providing pressurized fuel to the fuel hose, varying the pressure on the fuel hose by superimposing a specified base pressure with a pressure sequence in order to modulate a first signal to be transmitted, detecting the pressure being applied to the fuel hose by means of the vehicle, and extracting the first signal to be transmitted from the detected pressure.

Abstract: A pivotable junction box and driver housing unit includes a junction box having a junction box cavity, and a driver housing having a driver housing cavity to contain a light fixture driver. The junction box and the driver housing are attached to each other. The junction box and the driver housing are rotatable with respect to each other.