Patents by Inventor Philip W. Ingham
Philip W. Ingham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7901686Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: GrantFiled: August 3, 2005Date of Patent: March 8, 2011Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology Ltd.Inventors: Clifford Tabin, Valeria Marigo, Philip W. Ingham, Andrew P. McMahon
-
Patent number: 7781215Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: GrantFiled: December 5, 2006Date of Patent: August 24, 2010Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology Ltd.Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin
-
Publication number: 20080171328Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: ApplicationFiled: August 20, 2007Publication date: July 17, 2008Applicants: The President and Fellows of Harvard College, Imperial Cancer Research Technology LimitedInventors: Clifford Tabin, Valeria Marigo, Philip W. Ingham, Andrew P. McMahon
-
Patent number: 7144732Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: GrantFiled: April 28, 2004Date of Patent: December 5, 2006Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology InstituteInventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin
-
Patent number: 7060450Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: GrantFiled: November 13, 2000Date of Patent: June 13, 2006Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology Ltd.Inventors: Clifford Tabin, Valeria Marigo, Philip W. Ingham, Andrew P. McMahon
-
Patent number: 6884775Abstract: The present application is directed to the discovery that hedgehog proteins, and agents which effect the activities thereof, can be used to control the formation and/or maintenance of cartilage and bone.Type: GrantFiled: August 1, 1997Date of Patent: April 26, 2005Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology, Inc.Inventors: Clifford J. Tabin, Andrew P. McMahon, Philip W. Ingham, Andrea M. Vortkamp
-
Publication number: 20040224882Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: ApplicationFiled: August 25, 2003Publication date: November 11, 2004Applicants: Imperial Cancer Research Technology Limited, President and Fellows of Harvard CollegeInventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin
-
Patent number: 6664075Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by tissue patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: GrantFiled: December 13, 2000Date of Patent: December 16, 2003Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology Ltd.Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin, David A. Bumcrot, Elisa Marti-Gorostiza
-
Publication number: 20030190696Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by tissue patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: ApplicationFiled: December 13, 2000Publication date: October 9, 2003Applicant: President and Fellows of Harvard CollegeInventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin, David A. Bumcrot, Elisa Marti-Gorostiza
-
Patent number: 6630148Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: GrantFiled: October 20, 1997Date of Patent: October 7, 2003Assignees: Imperial Cancer Research Technology Ltd., President and Fellows of Harvard CollegeInventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin
-
Publication number: 20030186357Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: ApplicationFiled: June 5, 1995Publication date: October 2, 2003Inventors: PHILIP W. INGHAM, ANDREW P. MCMAHON, CLIFFORD J. TABIN
-
Patent number: 6610656Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: GrantFiled: October 20, 1997Date of Patent: August 26, 2003Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology, Ltd.Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin
-
Patent number: 6607913Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: GrantFiled: November 23, 1999Date of Patent: August 19, 2003Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin
-
Patent number: 6576237Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by tissue patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vetebrate tissue both in vitro and in vivo.Type: GrantFiled: August 16, 2000Date of Patent: June 10, 2003Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology Ltd.Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin, David A. Bumcrot, Elisa Marti-Gorostiza
-
Publication number: 20030054437Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: ApplicationFiled: October 20, 1997Publication date: March 20, 2003Inventors: PHILIP w INGham, ANDREW P. MCMAHON, CLIFFORD J TABIN
-
Patent number: 6384192Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: GrantFiled: October 20, 1997Date of Patent: May 7, 2002Assignees: President & Fellows of Harvard College, Imperial Cancer Research Technology, Ltd.Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin
-
Patent number: 6271363Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: GrantFiled: October 20, 1997Date of Patent: August 7, 2001Assignees: President & Fellows of Harvard College, Imperial Cancer Research Technology, Ltd.Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin
-
Patent number: 6261786Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: GrantFiled: July 2, 1996Date of Patent: July 17, 2001Assignees: Imperial Cancer Res. Technology, President & Fellows of Harvard CollegeInventors: Valeria Marigo, Clifford J. Tabin, Philip W. Ingham, Andrew P. McMahon
-
Patent number: 6165747Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by tissue patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: GrantFiled: June 5, 1995Date of Patent: December 26, 2000Assignees: President & Fellows of Harvard College, Imperial Cancer Research Technology, Ltd.Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin, David A. Bumcrot, Elisa Marti-Gorostiza
-
Patent number: 5844079Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: GrantFiled: December 14, 1994Date of Patent: December 1, 1998Assignee: President and Fellows of Harvard CollegeInventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin