Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

Abstract: A process for cladding precious metals to precipitation hardenable materials. In accordance with one aspect of the present invention, are the steps of (i) placing a precious metal layer of a first selected thickness atop a selected beryllium-copper alloy base metal strip of a second selected thickness to approximate a desired final product thickness, (ii) cold rolling the layer and strip to reduce their respective thicknesses by generally more than 50%, (iii) heating the layer and strip to a first selected temperature generally within a range of 1000.degree.-1300.degree. F., (iv) maintaining the first temperature for a first selected time to promote metallic bonding of the layer to the strip while softening the base metal, (v) pickling the layer and strip to remove surface oxides, (vi) cold rolling the layer and strip to a thickness generally 11% greater than that of the desired final product thickness, (vii) heating the layer and strip to a second selected temperature generally within a range of 1250.degree.