Patents by Inventor Philip Wilson Howard

Philip Wilson Howard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES
    Publication number: 20170258934
    Abstract: The present disclosure relates to the use of antibody-drug conjugates (ADCs) comprising pyrrolobenzodiazepine (PBD) dimers and anti-CD25 antibodies for use in treating disorders characterized by the presence of CD25+ve cells.
    Type: Application
    Filed: November 25, 2015
    Publication date: September 14, 2017
    Inventors: Patricius Henrikus Cornelis VAN BERKEL, Philip Wilson HOWARD, John HARTLEY
  • Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
    Patent number: 9745303
    Abstract: A method of synthesing a compound of formula (I) from a compound of formula (III).
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: August 29, 2017
    Assignee: MEDIMMUNE LIMITED
    Inventor: Philip Wilson Howard
  • PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF
    Publication number: 20170239365
    Abstract: A conjugate comprising a PBD dimer linked from the tether joining the two PBD units, wherein the linker is of formula (A1): (Formula (A1)) wherein RN1 is selected from H and C1-4 alkyl; L is a linker connected to a cell binding agent; CBA is the cell binding agent; n is an integer selected in the range of 0 to 48; Q is: (Formula (Q)), where Qx is such that Q is an amino-acid residue, a dipeptide residue or a tripeptide residue.
    Type: Application
    Filed: September 11, 2015
    Publication date: August 24, 2017
    Inventors: Philip Wilson HOWARD, Stephen John GREGSON, Jean-Noel LEVY
  • Pyrrolobenzodiazepines used to treat proliferative diseases
    Patent number: 9732084
    Abstract: Pyrrolobenzodiazepine dimers having a C2-C3 double bond and an aryl group at the C2 position on one monomer unit, and a C2-C3 double bond and either a conjugated double or triple bond at the C2 position or an alkyl group at the C2 position on the other monomer unit, and conjugates of these compounds.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: August 15, 2017
    Assignees: Medimmune Limited, Seattle Genetics Inc.
    Inventors: Philip Wilson Howard, Luke Masterson, Arnaud Tiberghien, Scott Jeffrey, Patrick Burke, Peter Senter
  • Pyrrolobenzodiazepines and targeted conjugates
    Patent number: 9713647
    Abstract: A compound, or a pharmaceutically acceptable salt or solvate thereof, or conjugates thereof, selected from the group consisting of: wherein: (a) R10 is H, and R11 is OH, ORA, where RA is saturated C1-4 alkyl; (b) R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or (c) R10 is H and R11 is SOzM, where z is 2 or 3 and M is a monovalent pharmaceutically acceptable cation, or both M together are a divalent pharmaceutically acceptable cation.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: July 25, 2017
    Assignees: SEATTLE GENETICS, INC., MEDIMMUNE LIMITED
    Inventors: Scott Jeffrey, Patrick Burke, Philip Wilson Howard
  • Pyrrolobenzodiazepines and targeted conjugates
    Patent number: 9707301
    Abstract: This invention relates to pyrrolobenzodiazepines (PBDs), in particular pyrrolobenzodiazepine dimers having a C2-C3 double bond and an aryl group at the C2 position in each monomer unit, and their inclusion in targeted conjugates. The differing substituent groups may offer advantages in the preparation and use of the compounds, particularly in their biological properties and the synthesis of conjugates, and the biological properties of these conjugates.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: July 18, 2017
    Assignees: SEATTLE GENETICS, INC., MEDIMMUNE LIMITED
    Inventors: Scott Jeffrey, Patrick Burke, Philip Wilson Howard
  • TARGETED PYRROLOBENZODIAZAPINE CONJUGATES
    Publication number: 20170143846
    Abstract: Provided are Conjugate comprising PBDs conjugated to a targeting agent and methods of using such PBDs.
    Type: Application
    Filed: February 1, 2017
    Publication date: May 25, 2017
    Inventors: Philip Wilson HOWARD, Scott JEFFREY, Patrick BURKE, Peter SENTER
  • Pyrrolobenzodiazepines and conjugates thereof
    Patent number: 9649390
    Abstract: A conjugate of formula (A):
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: May 16, 2017
    Assignee: MEDIMMUNE LIMITED
    Inventors: Philip Wilson Howard, John A. Flygare, Thomas Pillow, Binqing Wei
  • Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative diseases
    Patent number: 9624227
    Abstract: A compound with the formula I:
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: April 18, 2017
    Assignee: MEDIMMUNE LIMITED
    Inventors: Philip Wilson Howard, Stephen John Gregson, Luke Masterson
  • Targeted pyrrolobenzodiazapine conjugates
    Patent number: 9592240
    Abstract: Provided are Conjugate comprising PBDs conjugated to a targeting agent and methods of using such PBDs.
    Type: Grant
    Filed: January 14, 2016
    Date of Patent: March 14, 2017
    Assignees: SEATTLE GENETICS INC., MEDIMMUNE LIMITED
    Inventors: Philip Wilson Howard, Scott Jeffrey, Patrick Burke, Peter Senter
  • Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases
    Patent number: 9567340
    Abstract: A compound of formula I: or a pharmaceutically acceptable salt or solvate thereof.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: February 14, 2017
    Assignee: MEDIMMUNE LIMITED
    Inventor: Philip Wilson Howard
  • Pyrrolobenzodiazepines and conjugates thereof
    Patent number: 9562049
    Abstract: A compound with the formula I: and salts and solvates thereof.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: February 7, 2017
    Assignee: MEDIMMUNE LIMITED
    Inventor: Philip Wilson Howard
  • Pyrrolobenzodiazepines and targeted conjugates
    Patent number: 9526798
    Abstract: A compound, or a pharmaceutically acceptable salt or solvate thereof, or conjugates thereof, selected from the group consisting of formula wherein: (a) R10 is H, and R11 is OH, ORA, where RA is saturated C1-4 alkyl; (b) R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or (c) R10 is H and R11 is S02M, where z is 2 or 3 and M is a monovalent pharmaceutically acceptable cation, or both M together are a divalent pharmaceutically acceptable cation.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: December 27, 2016
    Assignees: SEATTLE GENETICS, INC., MEDIMMUNE LIMITED
    Inventors: Scott Jeffrey, Patrick Burke, Philip Wilson Howard
  • PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF
    Publication number: 20160310611
    Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, pharmaceutical compositions containing them, and to their use in therapy for the prevention treatment of cancer.
    Type: Application
    Filed: December 16, 2014
    Publication date: October 27, 2016
    Applicants: Genentech Inc., Medimmune Limited
    Inventors: John FLYGARE, Janet GUNZNER-TOSTE, Thomas PILLOW, Brian SAFINA, Vishal VERMA, Binqing WEI, Guiling ZHAO, Leanna STABEN, Philip Wilson HOWARD, Luke MASTERSON
  • PYRROLOBENZODIAZEPINES AND TARGETED CONJUGATES
    Publication number: 20160289239
    Abstract: A compound, or a pharmaceutically acceptable salt or solvate thereof, or conjugates thereof, selected from the group consisting of: wherein: (a) R10 is H, and R11 is OH, ORA, where RA is saturated C1-4 alkyl; (b) R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or (c) R10 is H and R11 is SOzM, where z is 2 or 3 and M is a monovalent pharmaceutically acceptable cation, or both M together are a divalent pharmaceutically acceptable cation.
    Type: Application
    Filed: June 14, 2016
    Publication date: October 6, 2016
    Inventors: Scott Jeffrey, Patrick Burke, Philip Wilson Howard
  • PYRROLOBENZODIAZEPINES AND TARGETED CONJUGATES
    Publication number: 20160287721
    Abstract: This invention relates to pyrrolobenzodiazepines (PBDs), in particular pyrrolobenzodiazepine dimers having a C2-C3 double bond and an aryl group at the C2 position in each monomer unit, and their inclusion in targeted conjugates. The differing substituent groups may offer advantages in the preparation and use of the compounds, particularly in their biological properties and the synthesis of conjugates, and the biological properties of these conjugates.
    Type: Application
    Filed: June 15, 2016
    Publication date: October 6, 2016
    Inventors: Scott JEFFREY, Patrick BURKE, Philip Wilson HOWARD
  • PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES
    Publication number: 20160263239
    Abstract: Conjugates of specific PBD dimers with an antibody that binds to PSMA, the antibody comprising a VH domain having the sequence according to any one of SEQ ID NOs. 1, 3, 5, 7, 8, 9, or 10, optionally further comprising a VL domain having the sequence 5 according to any one of SEQ ID NOs. 2, 4, 6, 11, 12, 13, 14, 15, 16, 17, or 18.
    Type: Application
    Filed: October 10, 2014
    Publication date: September 15, 2016
    Inventors: Philip Wilson Howard, Patricius Hendrikus Cornelis Van Berkel
  • PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES
    Publication number: 20160263242
    Abstract: Conjugates of specific PBD dimers with an antibody that that binds to CD19, the antibody comprising a VH domain having the sequence according to any one of SEQ ID NOs. 1, 2, 3, 4, 5 or 6, optionally further comprising a VL domain having the sequence according to any one of SEQ ID NOs. 7, 8, 9, 10, 11 or 12.
    Type: Application
    Filed: October 10, 2014
    Publication date: September 15, 2016
    Inventors: Philip Wilson Howard, Patricius Hendrikus Cornelis Van Berkel
  • PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES
    Publication number: 20160256561
    Abstract: Conjugates of specific PBD dimers with an antibody that that binds to HER2, the antibody comprising a VH domain having the sequence according to SEQ ID NO. 1.
    Type: Application
    Filed: October 10, 2014
    Publication date: September 8, 2016
    Inventors: Philip Wilson Howard, Patricius Hendrikus Cornelis Van Berkel
  • PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF
    Publication number: 20160250344
    Abstract: A compound which is selected from A: and salts and solvates thereof.
    Type: Application
    Filed: October 10, 2014
    Publication date: September 1, 2016
    Inventors: Philip Wilson Howard, Arnaud Tiberghien, Thais Cailleau