Patents by Inventor Philip Wilson

Philip Wilson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeted pyrrolobenzodiazapine conjugates
    Patent number: 10561739
    Abstract: Provided are Conjugate comprising PBDs conjugated to a targeting agent and methods of using such PBDs.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: February 18, 2020
    Assignees: SEATTLE GENETICS INC., MEDIMMUNE LIMITED
    Inventors: Philip Wilson Howard, Scott Jeffrey, Patrick Burke, Peter Senter
  • Pyrrolobenzodiazepine conjugates and their use for the treatment of cancer
    Patent number: 10543279
    Abstract: A conjugate of formula (I): L-(DL)p, wherein L is a Ligand unit, D is a Drug Linker unit of formula (II), wherein p is an integer of from 1 to 20.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: January 28, 2020
    Assignee: MEDIMMUNE LIMITED
    Inventors: Philip Wilson Howard, Thais Cailleau
  • Display screen mount
    Patent number: 10543791
    Abstract: A display screen mount mounts a display screen (6) to the rear of a seat (1). The mount includes a guide which defines a guide path to guide the display screen support (7) from a stowed position to a deployed position. The guide path also allows for adjustment of the viewing angle in the deployed position. The guide path has a linear portion (105) along which the display screen support (7) is guided into a deployed position in which the screen is visible to the user and a non-linear portion (106) which allows different viewing angles of the display screen (6) to be adopted in the deployed position.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: January 28, 2020
    Assignee: Bentley Motors Limtied
    Inventors: David Alan Rook, Philip Wilson
  • Peptidomimetic compounds and antibody-drug conjugates thereof
    Patent number: 10533058
    Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, pharmaceutical compositions containing them, and to their use in therapy for the prevention treatment of cancer.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: January 14, 2020
    Assignees: Genentech Inc., Medimmune Limited
    Inventors: John Flygare, Janet Gunzner-Toste, Thomas Pillow, Brian Safina, Vishal Verma, Binqing Wei, Guiling Zhao, Leanna Staben, Philip Wilson Howard, Luke Masterson
  • PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF
    Publication number: 20190388554
    Abstract: A compound which is either A: or B: and salts and solvates thereof, as well as their conjugates with a cell-binding agent.
    Type: Application
    Filed: May 14, 2019
    Publication date: December 26, 2019
    Inventor: Philip Wilson HOWARD
  • Anti-DLL3 antibody drug conjugates for treating cancer
    Patent number: 10478509
    Abstract: Provided are novel antibody drug conjugates (ADCs), and methods of using such ADCs to treat proliferative disorders.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: November 19, 2019
    Assignees: ABBVIE STEMCENTRX LLC, MEDIMMUNE LIMITED
    Inventors: Michael Torgov, Philip Wilson Howard
  • TARGETED PYRROLOBENZODIAZAPINE CONJUGATES
    Publication number: 20190336614
    Abstract: Provided are Conjugate comprising PBDs conjugated to a targeting agent and methods of using such PBDs.
    Type: Application
    Filed: April 11, 2019
    Publication date: November 7, 2019
    Inventors: Philip Wilson Howard, Scott Jeffrey, Patrick Burke, Peter Senter
  • PYRROLOBENZODIAZEPINE CONJUGATES
    Publication number: 20190307890
    Abstract: A conjugate of formula (I):L-(DL)p, wherein L is a Ligand unit, D is a Drug Linker unit of formula IIa, IIb or IIc, wherein p is an integer of from 1 to 20.
    Type: Application
    Filed: November 17, 2017
    Publication date: October 10, 2019
    Inventors: Philip Wilson HOWARD, Thais CAILLEAU
  • Pyrrolobenzodiazepines and conjugates thereof
    Patent number: 10420777
    Abstract: A conjugate comprising a PBD dimer linked from the tether joining the two PBD units, wherein the linker is of formula (A1):(Formula (A1)) wherein RN1 is selected from H and C1-4 alkyl; L is a linker connected to a cell binding agent; CBA is the cell binding agent; n is an integer selected in the range of 0 to 48; Q is: (Formula (Q)), where Qx is such that Q is an amino-acid residue, a dipeptide residue or a tripeptide residue.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: September 24, 2019
    Inventors: Philip Wilson Howard, Stephen John Gregson, Jean-Noel Levy
  • PYRROLOBENZODIAZEPINE CONJUGATES
    Publication number: 20190282705
    Abstract: A compound of formula (I): (I) and its conjugates.
    Type: Application
    Filed: October 13, 2017
    Publication date: September 19, 2019
    Inventors: Philip Wilson HOWARD, Stephen John GREGSON
  • Pyrrolobenzodiazepines
    Patent number: 10392393
    Abstract: A compound with the formula I, wherein R2 is of formula II, where A is a C5-7 aryl group, X is selected from the group consisting of: OH, SH, CO2H, COH, N?C?O, NHNH2, CONHNH2, (III), (IV), and NHRN, wherein RN is selected from H and C1-4 alkyl, and either: (i) Q1 is a single bond, and Q2 is selected from a single bond and —Z—(CH2)n—, where Z is selected from a single bond, O, S and NH and n is from 1 to 3; or (ii) Q1 is —CH?CH—, and Q2 is a single bond; and its conjugates.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: August 27, 2019
    Assignee: Medimmune Limited
    Inventors: Philip Wilson Howard, Thaïs Cailleau
  • Pyrrolobenzodiazepines and conjugates thereof
    Patent number: 10335497
    Abstract: A compound which is either A: or B: and salts and solvates thereof, as well as their conjugates with a cell-binding agent.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: July 2, 2019
    Assignee: MEDIMMUNE LIMITED
    Inventor: Philip Wilson Howard
  • Pyrrolobenzodiazepines and targeted conjugates
    Patent number: 10328084
    Abstract: A compound, or a pharmaceutically acceptable salt or solvate thereof, or conjugates thereof, selected from the group consisting of: wherein: (a) R10 is H, and R11 is OH, ORA, where RA is saturated C1-4 alkyl; (b) R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or (c) R10 is H and R11 is SOzM, where z is 2 or 3 and M is a monovalent pharmaceutically acceptable cation, or both M together are a divalent pharmaceutically acceptable cation.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: June 25, 2019
    Assignees: SEATTLE GENETICS, INC., MEDIMMUNE LIMITED
    Inventors: Scott Jeffrey, Patrick Burke, Philip Wilson Howard
  • Pyrrolobenzodiazepines and targeted conjugates
    Patent number: 10329352
    Abstract: This invention relates to pyrrolobenzodiazepines (PBDs), in particular pyrrolobenzodiazepine dimers having a C2-C3 double bond and an aryl group at the C2 position in each monomer unit, and their inclusion in targeted conjugates. The differing substituent groups may offer advantages in the preparation and use of the compounds, particularly in their biological properties and the synthesis of conjugates, and the biological properties of these conjugates.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: June 25, 2019
    Assignees: SEATTLE GENETICS, INC., MEDIMMUNE LIMITED
    Inventors: Scott Jeffrey, Patrick Burke, Philip Wilson Howard
  • END SHIELD FOR USE IN AN ELECTRIC MACHINE AND METHOD OF FORMING THE SAME
    Publication number: 20190157939
    Abstract: An end shield for an electric machine having a rotational axis includes a plate portion, a circumferential bearing retainer extending axially from the plate portion, and an inner hub coupled to the plate portion and spaced radially inward from the bearing retainer to define a circular groove therebetween. The end shield also includes a pair of boundary walls extending between the bearing retainer and the inner hub across the circular groove such that the pair of boundary walls separate the circular groove into a first chamber and a second chamber. The first chamber is configured to receive a supply of grease therein.
    Type: Application
    Filed: November 21, 2017
    Publication date: May 23, 2019
    Inventor: PHILIP A. WILSON, JR.
  • PYRROLOBENZODIAZEPINE CONJUGATES AND THEIR USE FOR THE TREATMENT OF CANCER
    Publication number: 20190134205
    Abstract: A conjugate of formula (I): L-(DL)p, wherein L is a Ligand unit, D is a Drug Linker unit of formula (II), wherein p is an integer of from 1 to 20.
    Type: Application
    Filed: April 28, 2017
    Publication date: May 9, 2019
    Inventors: Philip Wilson HOWARD, Thais CAILLEAU
  • PYRROLOBENZODIAZEPINE CONJUGATES
    Publication number: 20190125893
    Abstract: A conjugate of formula (I): L-(DL)p (I) wherein L is a Ligand unit, D is a Drug Linker unit of formula (II) wherein p is an integer of from 1 to 20.
    Type: Application
    Filed: February 10, 2017
    Publication date: May 2, 2019
    Inventors: Philip Wilson Howard, Luke Masterson
  • PYRROLOBENZODIAZEPINES
    Publication number: 20190055254
    Abstract: A compound with the formula I, wherein R2 is of formula II, where A is a C5-7 aryl group, X is selected from the group consisting of: OH, SH, CO2H, COH, N?C?O, NHNH2, CONHNH2, (III), (IV), and NHRN, wherein RN is selected from H and C1-4 alkyl, and either: (i) Q1 is a single bond, and Q2 is selected from a single bond and —Z—(CH2)n—, where Z is selected from a single bond, O, S and NH and n is from 1 to 3; or (ii) Q1 is —CH?CH—, and Q2 is a single bond; and its conjugates.
    Type: Application
    Filed: January 26, 2017
    Publication date: February 21, 2019
    Inventors: Philip Wilson HOWARD, Thaïs CAILLEAU
  • Pyrrolobenzodiazepines and conjugates thereof
    Patent number: 10188746
    Abstract: A conjugate of formula (A): Wherein Y is selected from formulae A1 and A2: Z1 is a C1-3 alkylene group; Z2 is a C1-3 alkylene group; Q is: where QX is such that Q is an amino-acid residue, a dipeptide residue or a tripeptide residue; L is a linker connected to a cell binding agent; CBA is the cell binding agent; and n is an integer between 0 and 48.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: January 29, 2019
    Assignee: MEDIMMUNE LIMITED
    Inventor: Philip Wilson Howard
  • NOVEL ANTIBODY CONJUGATES AND USES THEREOF
    Publication number: 20180318441
    Abstract: Provided are novel antibody drug conjugates (ADCs), and methods of using such ADCs to treat proliferative disorders.
    Type: Application
    Filed: April 5, 2018
    Publication date: November 8, 2018
    Applicants: ABBVIE STEMCENTRX LLC, MEDIMMUNE LIMITED
    Inventors: Michael TORGOV, Philip Wilson HOWARD