Patents by Inventor Philip Wuthrich

Philip Wuthrich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10478498
    Abstract: The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid protein formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions. The inventive methods can also yield a higher stability of a liquid protein formulation.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: November 19, 2019
    Assignee: REFORM BIOLOGICS, LLC
    Inventors: David S. Soane, Philip Wuthrich, Rosa Casado Portilla, Robert P. Mahoney, Mark Moody, Daniel G. Greene
  • Patent number: 10472943
    Abstract: The invention provides for modified proppants, comprising a proppant particle and a hydrogel coating, wherein the hydrogel coating localizes on the surface of the proppant particle to produce the modified proppant, methods of manufacturing such proppants and methods of use.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: November 12, 2019
    Assignee: SELF-SUSPENDING PROPPANT LLC
    Inventors: Robert P. Mahoney, David S. Soane, Marie K. Herring, Kevin P. Kincaid, Rosa Casado Portilla, Philip Wuthrich
  • Publication number: 20190275159
    Abstract: The invention encompasses therapeutic formulations comprising a protein active ingredient and a stabilizing excipient, methods of improving stability in a therapeutic formulation comprising a protein active ingredient by adding a stability-improving amount of a stabilizing excipient to the therapeutic formulation, and methods of reducing adverse infusion-related effects in a patient, comprising administering to a patient in need thereof a therapeutic formulation comprising a protein active ingredient and a stabilizing excipient.
    Type: Application
    Filed: March 15, 2019
    Publication date: September 12, 2019
    Inventors: David S. Soane, Robert P. Mahoney, Philip Wuthrich, Daniel G. Greene
  • Publication number: 20190262455
    Abstract: The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions.
    Type: Application
    Filed: February 25, 2019
    Publication date: August 29, 2019
    Inventors: David S. Soane, Philip Wuthrich, Rosa Casado Portilla, Robert P. Mahoney, Mark Moody
  • Patent number: 10279048
    Abstract: The invention encompasses therapeutic formulations comprising a protein active ingredient and a stabilizing excipient, methods of improving stability in a therapeutic formulation comprising a protein active ingredient by adding a stability-improving amount of a stabilizing excipient to the therapeutic formulation, and methods of reducing adverse infusion-related effects in a patient, comprising administering to a patient in need thereof a therapeutic formulation comprising a protein active ingredient and a stabilizing excipient.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: May 7, 2019
    Assignee: REFORM BIOLOGICS, LLC
    Inventors: David S. Soane, Robert P. Mahoney, Philip Wuthrich, Daniel G. Greene
  • Publication number: 20190054175
    Abstract: Disclosed herein are methods for improving a parameter of a protein-related process comprising providing a viscosity-reducing excipient compound selected from the group consisting of hindered amines, anionic aromatics, functionalized amino acids, oligopeptides, short-chain organic acids, and low molecular weight aliphatic polyacids, and adding a viscosity-reducing amount of the viscosity-reducing excipient compound to a carrier solution for the protein-related process, wherein the carrier solution contains a protein of interest, and carrier solutions comprising a liquid medium in which is dissolved a protein of interest, and a viscosity-reducing excipient, wherein the viscosity of the carrier solution has a lower viscosity that that of a control solution that is substantially similar to the carrier solution except for the presence of the viscosity-reducing excipient.
    Type: Application
    Filed: February 14, 2018
    Publication date: February 21, 2019
    Inventors: David S. Soane, Philip Wuthrich, Robert P. Mahoney, Mark Moody, Daniel G. Greene, Neil L. Schauer
  • Publication number: 20180194991
    Abstract: The invention provides for modified proppants, comprising a proppant particle and a hydrogel coating, wherein the hydrogel coating localizes on the surface of the proppant particle to produce the modified proppant, methods of manufacturing such proppants and methods of use.
    Type: Application
    Filed: October 2, 2017
    Publication date: July 12, 2018
    Inventors: Robert P. Mahoney, David S. Soane, Marie K. Herring, Kevin P. Kincaid, Rosa Casado Portilla, Philip Wuthrich
  • Patent number: 10016513
    Abstract: The invention encompasses therapeutic formulations comprising a protein active ingredient and a stabilizing excipient, methods of improving stability in a therapeutic formulation comprising a protein active ingredient by adding a stability-improving amount of a stabilizing excipient to the therapeutic formulation, and methods of reducing adverse infusion-related effects in a patient, comprising administering to a patient in need thereof a therapeutic formulation comprising a protein active ingredient and a stabilizing excipient.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: July 10, 2018
    Assignee: Reform Biologics, LLC
    Inventors: David S. Soane, Robert P. Mahoney, Philip Wuthrich, Daniel G. Greene
  • Patent number: 10012061
    Abstract: The invention provides formulations for facilitating the removal of oil from a surface using a chisel composition, wherein the chisel composition includes a polymer having one or more binding points with a high affinity for the surface, and one or more hydrophilic segments that form a hydrophilic coating on the surface, rendering the surface water-wet and thereby facilitating the removal of oil from the surface. The invention also provides for methods of use of such formulations.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: July 3, 2018
    Assignee: Soane Energy, LLC
    Inventors: David S. Soane, Rosa Casado Portilla, Robert P. Mahoney, Gangadhar Jogikalmath, Philip Wuthrich, Ian Slattery
  • Publication number: 20180044578
    Abstract: The invention provides for modified proppants, comprising a proppant particle and a hydrogel coating, wherein the hydrogel coating localizes on the surface of the proppant particle to produce the modified proppant, methods of manufacturing such proppants and methods of use.
    Type: Application
    Filed: October 2, 2017
    Publication date: February 15, 2018
    Inventors: Robert P. Mahoney, David S. Soane, Marie K. Herring, Kevin P. Kincaid, Rosa Casado Portilla, Philip Wuthrich
  • Publication number: 20180015169
    Abstract: The invention encompasses therapeutic formulations comprising a protein active ingredient and a stabilizing excipient, methods of improving stability in a therapeutic formulation comprising a protein active ingredient by adding a stability-improving amount of a stabilizing excipient to the therapeutic formulation, and methods of reducing adverse infusion-related effects in a patient, comprising administering to a patient in need thereof a therapeutic formulation comprising a protein active ingredient and a stabilizing excipient.
    Type: Application
    Filed: August 14, 2017
    Publication date: January 18, 2018
    Inventors: David S. Soane, Robert P. Mahoney, Philip Wuthrich, Daniel G. Greene
  • Publication number: 20180015168
    Abstract: The invention encompasses therapeutic formulations comprising a protein active ingredient and a stabilizing excipient, methods of improving stability in a therapeutic formulation comprising a protein active ingredient by adding a stability-improving amount of a stabilizing excipient to the therapeutic formulation, and methods of reducing adverse infusion-related effects in a patient, comprising administering to a patient in need thereof a therapeutic formulation comprising a protein active ingredient and a stabilizing excipient.
    Type: Application
    Filed: July 12, 2017
    Publication date: January 18, 2018
    Inventors: David S. Soane, Robert P. Mahoney, Philip Wuthrich, Daniel G. Greene
  • Patent number: 9867881
    Abstract: The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: January 16, 2018
    Assignee: Reform Biologics, LLC
    Inventors: David S. Soane, Philip Wuthrich, Rosa Casado Portilla, Robert P. Mahoney, Mark Moody
  • Publication number: 20170232103
    Abstract: The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid protein formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions. The inventive methods can also yield a higher stability of a liquid protein formulation.
    Type: Application
    Filed: October 21, 2016
    Publication date: August 17, 2017
    Inventors: David S. Soane, Philip Wuthrich, Rosa Casado Portilla, Robert P. Mahoney, Mark Moody, Daniel G. Greene
  • Publication number: 20170157256
    Abstract: The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions.
    Type: Application
    Filed: February 16, 2017
    Publication date: June 8, 2017
    Inventors: David S. Soane, Philip Wuthrich, Rosa Casado Portilla, Robert P. Mahoney, Mark Moody
  • Patent number: 9605051
    Abstract: The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: March 28, 2017
    Assignee: REFORM BIOLOGICS, LLC
    Inventors: David S. Soane, Philip Wuthrich, Rosa Casado Portilla, Robert P. Mahoney, Mark Moody
  • Publication number: 20160200966
    Abstract: The invention provides for modified proppants, comprising a proppant particle and a hydrogel coating, wherein the hydrogel coating localizes on the surface of the proppant particle to produce the modified proppant, methods of manufacturing such proppants and methods of use.
    Type: Application
    Filed: March 23, 2016
    Publication date: July 14, 2016
    Inventors: Robert P. Mahoney, David S. Soane, Marie K. Herring, Kevin P. Kincaid, Rosa Casado Portilla, Philip Wuthrich
  • Publication number: 20160096879
    Abstract: The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions.
    Type: Application
    Filed: December 11, 2015
    Publication date: April 7, 2016
    Inventors: David S. Soane, Philip Wuthrich, Rosa Casado Portilla, Robert P. Mahoney, Mark Moody
  • Patent number: 9297244
    Abstract: The invention provides for modified proppants, comprising a proppant particle and a hydrogel coating, wherein the hydrogel coating localizes on the surface of the proppant particle to produce the modified proppant, methods of manufacturing such proppants and methods of use.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 29, 2016
    Assignee: Self-Suspending Proppant LLC
    Inventors: Robert P. Mahoney, David S. Soane, Marie K. Herring, Kevin P. Kincaid, Rosa Casado Portilla, Philip Wuthrich
  • Publication number: 20160074515
    Abstract: The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions.
    Type: Application
    Filed: June 19, 2015
    Publication date: March 17, 2016
    Inventors: David S. Soane, Philip Wuthrich, Rosa Casado Portilla, Robert P. Mahoney, Mark Moody