Abstract: The disclosure provides tangential flow depth filtration (TFDF) systems which exhibit improved filter fluxes and process capacities and reduced fouling characteristics. The TFDF systems of the disclosure optionally utilize tubular depth filters (TDF). Methods are provided which include the passage of a non-laminar flow through at least a portion of a length of a TDF in a TFDF system.

Abstract: The present invention relates to hollow fiber tangential flow depth filtration media adapted for perfusion bioprocessing, and related TFDF filtration units, bioprocessing systems, and methods, including methods for perfusion cell culture. The hollow fiber elements of the present invention combine a relatively thin porous wall with a relatively low porosity to provide filtration media resistant to fouling during perfusion culture.

Abstract: The invention provides tangential flow filtration systems and methods for capture and harvest of a biologic product, and related compositions.

Abstract: The disclosure provides tangential flow depth filtration (TFDF) systems which exhibit improved filter fluxes and process capacities and reduced fouling characteristics. The TFDF systems of the disclosure optionally utilize tubular depth filters (TDF). Methods are provided which include the passage of a non-laminar flow through at least a portion of a length of a TDF in a TFDF system.

Abstract: The disclosure provides tangential flow depth filtration (TFDF) systems which exhibit improved filter fluxes and process capacities and reduced fouling characteristics. The TFDF systems of the disclosure optionally utilize tubular depth filters (TDF). Methods are provided which include the passage of a non-laminar flow through at least a portion of a length of a TDF in a TFDF system.

Abstract: A micro alternating tangential flow (microATF) perfusion filter includes a hollow cylinder having a proximal end and a distal end. The proximal end is connected in series to a permeate chamber, followed by a retentate chamber. The proximal end either (i) terminates in or at the permeate chamber, or (ii) terminates in or at the retentate chamber. The portion of the proximal end within the permeate chamber, in a case of (ii), possesses at least one opening allowing fluid communication between an inside of the hollow cylinder and the permeate chamber. The microATF perfusion filter further includes an inlet, positioned over the retentate chamber, for communication with a source of positive or negative pressure, and an outlet, positioned in a wall of the permeate chamber, which can be connected to a check valve, which, in turn, can be connected to a hydrophobic fluid vent filter.

Abstract: This disclosure relates to the use of a hydrophobic hollow fiber filter for the filtration of cell cultures and other biological perfusions, due to its resistance to fouling, as well as the ability to filter solutions with a high solid content. A hydrophobic hollow fiber filter may be used within a filter housing in conjunction with a process vessel and a traditional separation system. When the system is used with alternating tangential flow or tangential flow filtration, the hydrophobic hollow fiber filter results in more effective filtration of the filtrate, leading to greater concentration of the retentate, even in solution containing high levels of solids.

Abstract: A filter screening tool, system, and method allowing high throughput screening of filters (such as hollow fiber filters), such as for use in bioprocessing workflows. Feed material may be fed through different filter modules to assess, measure, analyze, determine, evaluate, teste, compare, screen, etc., properties or characteristics, etc., of filters within the filter modules. Each filter module may house a different type (e.g., material or configuration) of filter so that different filters may be compared and screened, such as for a selected use.

Abstract: The present disclosure relates to hollow fiber tangential flow filter units, including hollow fiber tangential flow depth filter units, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.

Abstract: A micro alternating tangential flow (microATF) perfusion filter includes a hollow cylinder having a proximal end and a distal end. The proximal end is connected in series to a permeate chamber, followed by a retentate chamber. The proximal end either (i) terminates in or at the permeate chamber, or (ii) terminates in or at the retentate chamber. The portion of the proximal end within the permeate chamber, in a case of (ii), possesses at least one opening allowing fluid communication between an inside of the hollow cylinder and the permeate chamber. The microATF perfusion filter further includes an inlet, positioned over the retentate chamber, for communication with a source of positive or negative pressure, and an outlet, positioned in a wall of the permeate chamber, which can be connected to a check valve, which, in turn, can be connected to a hydrophobic fluid vent filter.

Abstract: Devices, systems, and methods for continually degassing/venting a feedstream within a filtration system. The filtration system may include a filter device utilizing hollow fiber filters to filter the feedstream. Additional venting hollow fiber filters vent gas from the filtration system to outside the filtration system. The venting hollow fiber filters may have ends which expose the interior lumens thereof to outside the filter unit to vent gases which pass through the walls of the hollow fiber filters. Degassed permeate thus flows through the filtering hollow fiber filters.

Abstract: A micro alternating tangential flow (microATF) perfusion filter includes a hollow cylinder having a proximal end and a distal end. The proximal end is connected in series to a permeate chamber, followed by a retentate chamber. The proximal end either (i) terminates in or at the permeate chamber, or (ii) terminates in or at the retentate chamber. The portion of the proximal end within the permeate chamber, in a case of (ii), possesses at least one opening allowing fluid communication between an inside of the hollow cylinder and the permeate chamber. The microATF perfusion filter further includes an inlet, positioned over the retentate chamber, for communication with a source of positive or negative pressure, and an outlet, positioned in a wall of the permeate chamber, which can be connected to a check valve, which, in turn, can be connected to a hydrophobic fluid vent filter.

Abstract: The disclosure provides tangential flow depth filtration (TFDF) systems which exhibit improved filter fluxes and process capacities and reduced fouling characteristics. The TFDF systems of the disclosure optionally utilize tubular depth filters (TDF). Methods are provided which include the passage of a non-laminar flow through at least a portion of a length of a TDF in a TFDF system.

Abstract: The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing applications, systems employing such filters, and methods of filtration using the same.

Abstract: This disclosure relates to the use of a hydrophobic hollow fiber filter for the filtration of cell cultures and other biological perfusions, due to its resistance to fouling, as well as the ability to filter solutions with a high solid content. A hydrophobic hollow fiber filter may be used within a filter housing in conjunction with a process vessel and a traditional separation system. When the system is used with alternating tangential flow or tangential flow filtration, the hydrophobic hollow fiber filter results in more effective filtration of the filtrate, leading to greater concentration of the retentate, even in solution containing high levels of solids.

Abstract: Media enhanced mobile payments enable a user to make payments and payment requests that include additional media. The user may transmit a text-based message that may be used to update an account associated with a recipient. Additional media, such as a personalized voice recording, may be acquired by a host from the user, and may be associated with the text-based message. The additional media may be transmitted to the recipient identified in the text-based message. In some aspects, the text-based message may be a short messaging service (SMS) text message. Further aspects may include the host connecting to the user via a telephone call to record the personalized voice recording.

Abstract: Embodiments relate to location determination of computing devices. An example system includes a processor configurable to identify, from a first device, a second device transmitting wireless signals to the first device. The processor is configurable to determine, from the first device, a signal level of the wireless signals received by the first device from the second device. The processor is configurable to identify, from the first device, a third device transmitting wireless signals to the second device. The processor is configurable to determine, from the first device, a signal level of the wireless signals received by the second device from the third device. The processor is configurable to derive a location status of the first device based on the identification of the second and third devices and the signal levels of the wireless signals received by the first and second devices from the second and third devices, respectively.

Abstract: Embodiments relate generally to determining a location of a computing device. An example system may include a processor. The processor may be configurable to receive a current state of the computing device. The current state may be a charging or non-charging state. The charging state may be a state in which an energy source of the computing device is connected to and/or being charged by an external energy source. The non-charging state may be one in which the energy source is not connected to and/or not being charged by the external energy source. The processor may be configurable to receive information pertaining to wireless signals of a WLAN. The information may include an identification of a first transmitting device. The processor may also be configurable to derive a location status of the computing device based on the current state of the computing device and identification of the first transmitting device.

Abstract: Embodiments relate to methods, systems, and devices for managing voice communications of computing devices. The method may include receiving a first user identification and first specified time period for enabling voice communications on a first computing device for the first user identification. The method may include associating a first unique identifier with the first computing device and first user identification. The method may include configuring the first computing device to receive incoming voice communications directed to the first unique identifier. The method may include receiving a second user identification and second specified time period for enabling voice communications on the first computing device for the second user identification. The method may include associating a second unique identifier with the first computing device and second user identification.

Abstract: Embodiments relate to location determination of computing devices. An example system includes a processor configurable to identify, from a first device, a second device transmitting wireless signals to the first device. The processor is configurable to determine, from the first device, a transmission time of the wireless signals received by the first device from the second device. The processor is configurable to identify, from the first device, a third device transmitting wireless signals to the second device. The processor is configurable to determine, from the first device, a transmission time of the wireless signals received by the second device from the third device. The processor is configurable to derive a location status of the first device based on the identification of the second and third devices and the transmission times of the wireless signals received by the first and second devices from the second and third devices, respectively.