Abstract: An amplifier arrangement can provide a varying electrode voltage to an ion optical device. The amplifier arrangement comprises: a high-speed amplifier, configured to receive an input to the amplifier arrangement and provide a low voltage output; and a low-speed controllable voltage source, arranged to float on the low voltage output and configured to provide a high voltage output of the amplifier arrangement. The high voltage output of the amplifier arrangement is fed back for control of the high-speed amplifier. The amplifier arrangement beneficially forms part of a power supply for supplying the varying electrode voltage, for example as part of an ion analytical system.

Abstract: A Time of Flight (TOF) mass analyser comprises an ion source, a detector, an electrode, and a resistive divider comprising first and second resistors. The ion source and the detector define an ion flight path from the ion source to the detector. The electrode is arranged along the ion flight path and receives an output voltage. Thermal expansion produces a first mass shift/Kelvin of detected ions. The resistive divider is thermally coupled to the TOF mass analyser to receive an input voltage and output an output voltage to the electrode. The first and second resistors have respective first and second temperature coefficients that provide a voltage shift/Kelvin to the output voltage to the electrode producing a second mass shift/Kelvin of detected ions, compensating for the first mass shift/Kelvin.

Abstract: A voltage supply for a mass analyser is provided. The voltage supply comprises a voltage source, a first voltage output, a second voltage output, and a voltage divider network. The first voltage output is configured to provide a first voltage to a first electrode of the mass analyser, wherein the first electrode of the mass analyser has a first mass shift per volt perturbation. The second voltage output is configured to provide a second voltage to a second electrode of the mass analyser, wherein the second electrode of the mass analyser has a second mass shift per volt perturbation. The second mass shift per volt perturbation opposes the first mass shift per volt perturbation. The voltage divider network comprises a first resistor and a second resistor.

Abstract: A dual analyser mass spectrometer obtains MS1/MS2 scans of positive and negative ions by: operating an ion source and processing region at a first polarity; performing, by a first mass analyser (FMA) at the first polarity, MS1 or MS2 scan(s); switching polarity of the FMA to a second polarity; performing, by a second mass analyser (SMA) at the first polarity, MS1 or MS2 scan(s), wherein at least part of the MS1 or MS2 scan(s) performed by the SMA is performed while the FMA is switching polarity. Alternatively, the FMA may be operated at a first polarity and the SMA at a second polarity opposite to the first, and after initiating at least one MS1 scan and/or MS2 scan by the FMA, switching the polarity of the source and ion processing region to a second polarity and performing at least one MS1 scan and/or MS2 scan with the SMA.

Abstract: There is described a multi-reflection time-of-flight (MR-ToF) mass analyser for a mass spectrometer, comprising a first and second mirror electrodes respectively configured to operate at a first polarity and at a second polarity. The mass analyser is configured for polarity switching and further comprises: a first regulator coupled to one or more first HV switches and configured to provide an electric potential to the first mirror electrode; and one or more second regulators each coupled to one or more second HV switches, each of the one or more second regulators configured to provide an electric potential to a respective second mirror electrode. The first and second HV switches are configured to swap the polarity supplied to the first regulator and the one or more second regulators.

Abstract: A voltage supply for a mass analyser is provided. The voltage supply comprises a voltage source, a first voltage output, a second voltage output, and a voltage divider network. The first voltage output is configured to provide a first voltage to a first electrode of the mass analyser, wherein the first electrode of the mass analyser has a first mass shift per volt perturbation. The second voltage output is configured to provide a second voltage to a second electrode of the mass analyser, wherein the second electrode of the mass analyser has a second mass shift per volt perturbation. The second mass shift per volt perturbation opposes the first mass shift per volt perturbation. The voltage divider network comprises a first resistor and a second resistor. The first resistor is configured to define the first voltage, the first resistor having a first temperature coefficient. The second resistor is configured to define the second voltage, the second resistor having a second temperature coefficient.

Abstract: A voltage supply for a mass analyser is provided. The voltage supply comprises a voltage source, a first voltage output, a second voltage output, and a voltage divider network. The first voltage output is configured to provide a first voltage to a first electrode of the mass analyser, wherein the first electrode of the mass analyser has a first mass shift per volt perturbation. The second voltage output is configured to provide a second voltage to a second electrode of the mass analyser, wherein the second electrode of the mass analyser has a second mass shift per volt perturbation. The second mass shift per volt perturbation opposes the first mass shift per volt perturbation. The voltage divider network comprises a first resistor and a second resistor.

Abstract: A Time of Flight (TOF) mass analyser comprises an ion source, a detector, an electrode, and a resistive divider comprising first and second resistors. The ion source and the detector define an ion flight path from the ion source to the detector. The electrode is arranged along the ion flight path and receives an output voltage. Thermal expansion produces a first mass shift/Kelvin of detected ions. The resistive divider is thermally coupled to the TOF mass analyser to receive an input voltage and output an output voltage to the electrode. The first and second resistors have respective first and second temperature coefficients that provide a voltage shift/Kelvin to the output voltage to the electrode producing a second mass shift/Kelvin of detected ions, compensating for the first mass shift/Kelvin.

Abstract: A voltage supply and a method for calibrating the voltage supply are provided. The voltage supply is for providing a reference voltage to supply a voltage to at least one electrode. The voltage supply comprises: an ultra-stable DC voltage source, an accurate DC voltage source, a tuning unit, a comparator, and a control unit. An ultra-stable voltage is applied to the tuning unit, which is provided based on a supplied voltage of the ultra-stable DC voltage source. The tuning unit provides an output voltage. A voltage based on the output voltage of the tuning unit is compared by the comparator with an accurate voltage. The accurate voltage is provided based on a supplied voltage of the accurate DC voltage source.

Abstract: A voltage supply for a mass analyser is provided. The voltage supply comprises a voltage source, a first voltage output, a second voltage output, and a voltage divider network. The first voltage output is configured to provide a first voltage to a first electrode of the mass analyser, wherein the first electrode of the mass analyser has a first mass shift per volt perturbation. The second voltage output is configured to provide a second voltage to a second electrode of the mass analyser, wherein the second electrode of the mass analyser has a second mass shift per volt perturbation. The second mass shift per volt perturbation opposes the first mass shift per volt perturbation. The voltage divider network comprises a first resistor and a second resistor. The first resistor is configured to define the first voltage, the first resistor having a first temperature coefficient. The second resistor is configured to define the second voltage, the second resistor having a second temperature coefficient.

Abstract: A voltage supply and a method for calibrating the voltage supply are provided. The voltage supply is for providing a reference voltage to supply a voltage to at least one electrode. The voltage supply comprises: an ultra-stable DC voltage source, an accurate DC voltage source, a tuning unit, a comparator, and a control unit. An ultra-stable voltage is applied to the tuning unit, which is provided based on a supplied voltage of the ultra-stable DC voltage source. The tuning unit provides an output voltage. A voltage based on the output voltage of the tuning unit is compared by the comparator with an accurate voltage. The accurate voltage is provided based on a supplied voltage of the accurate DC voltage source.

Abstract: A gas analyzing device including at least one ion mobility spectrometer is provided. The gas analyzing device also includes an energy supply device interacting with a reaction chamber of the ion mobility spectrometer which is designed to manipulate the density of free reactant ions in the reaction chamber by supplying energy. A method for analyzing gas by means of a gas analyzing device according to the ion mobility spectrometry is also provided.

Abstract: The invention relates to a gas analyzing device (1) which comprises at least one ion mobility spectrometer (2). Said gas analyzing device (1) also comprises an energy supply device (50) interacting with a reaction chamber (5) of the ion mobility spectrometer (2) which is designed to manipulate the density of free reactant ions in the reaction chamber (5) by supplying energy. The invention also relates to a method for analyzing gas by means of a gas analyzing device according to the ion mobility spectrometry.