Patents by Inventor Philipp Ellinger
Philipp Ellinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240124572Abstract: The present invention is related to agents capable of binding to and inhibiting or antagonizing the action of IL-11 and/or or IL-11RA for the treatment and/or prevention of abnormal uterine bleeding, which comprises heavy menstrual bleeding, prolonged bleeding, altered bleeding pattern, dysmenorrhea, as well as of the underlying diseases leiomyoma and endometriosis and the use of the agent to inhibit menstruation. Furthermore, the invention provides novel IL-11 antibodies.Type: ApplicationFiled: February 24, 2022Publication date: April 18, 2024Inventors: Maik Stefan Wilhelm OBENDORF, Frank SACHER, Jörg MÜLLER, Ralf LESCHE, Christian VOTSMEIER, Stephan MÄRSCH, Jan TEBBE, Philipp ELLINGER, Patrick Michael SMITH, Jenny FITTING, Katharina FILARSKY, Mathias GEHRMANN, Marcus KARLSTETTER, Ernst WEBER, Mark TRAUTWEIN
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Publication number: 20230250178Abstract: The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-cynomolgus, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human, cynomolgus and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells.Type: ApplicationFiled: June 25, 2021Publication date: August 10, 2023Inventors: Sandra BERNDT, Katharina FILARSKY, Philipp ELLINGER, Beatrix STELTE-LUDWIG, Sabine HOFF, Helge ROIDER, Ernst WEBER, Mark TRAUTWEIN, Christian VOTSMEIER, Nikolaus PAWLOWSKI, Uwe GRITZAN, Pascale BUCHMANN, Christian BERTLING, Oliver VON AHSEN, Wiebke Maria NADLER, Su-Yi TSENG, Pedro PAZ, Phaik Lyn OH, Patrick JONES, Matyas GORJANACZ
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Publication number: 20220389096Abstract: The present disclosure relates to an isolated antibody or antigen-binding fragment thereof that binds to human Sema3A. The isolated antibody or antigen-binding fragment according to the present disclosure i) binds to human Sema3A of the sequence of SEQ ID NO: 600 with a dissociation constant (KD)?50 nM, ?20 nM, ?10 nM, ?1 nM, or ?0.1 nM; ii) cross-reacts with mouse, cynomolgus, rat, pig and/or dog Sema3A, particularly wherein said isolated antibody or antigen-binding fragment thereof binds to mouse, cynomolgus, rat, pig and/or dog Sema3A with a dissociation constant (KD)?50 nM, ?20 nM, ?10 nM, ?1 nM, or ?0.1 nM; iii) binds to human Sema3A of the sequence of SEQ ID NO: 600 with a binding activity as measured by surface plasmon resonance (SPR) of ?60%, ?70%, ?80%, or ?90%; iv) inhibits the activity of human Sema3A of the sequence of SEQ ID NO: 600 in an in vitro mesangial cell migration assay with an EC50 of ?10 nM, ?5 nM, ?2.Type: ApplicationFiled: March 28, 2022Publication date: December 8, 2022Inventors: Dorian SCHÖNFELD, Karoline DRÖBNER, Ernst WEBER, Katharina FILARSKY, Philipp ELLINGER, Fionnuala Mary MCALEESE ESER, Ingo FLAMME, Winfried WUNDERLICH, Antje SCHMIDT, Yalda SEDAGHAT, Kenneth YOUNG
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Patent number: 11104895Abstract: Described herein are methods and means for reliably releasing maternal and/or paternal DNA from single seeds without substantially affecting the subsequent germination of the seeds. The methods are particularly suited for genome analysis of small grain cereals, including wheat. The methods may include enzymatic treatments for improved DNA recovery.Type: GrantFiled: March 29, 2017Date of Patent: August 31, 2021Assignee: BASF SEInventors: Kristof Van der Meeren, Rainhard Koch, Philipp Ellinger, Nina Jansen, Stephen Rae, Martin Clausen
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Patent number: 10976573Abstract: A computer-implemented method for providing a lens shape for an ophthalmic lens is disclosed. Further, there is provided a method for angular smoothing of a surface determined by carrier lines radially outwards of a prescription zone bordered by a first boundary line. In addition, there is provided an ophthalmic lens, in particular, a spectacle lens. Moreover, a method for minimizing the difference in thickness between two ophthalmic lenses for the same spectacles is provided. A computer program product and a machine-readable storage medium are provided as well.Type: GrantFiled: May 3, 2019Date of Patent: April 13, 2021Assignee: Carl Zeiss Vision International GmbHInventors: Ray Steven Spratt, Philipp Ellinger, Helmut Wietschorke, Angela Nolan, Saulius Varnas
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Patent number: 10875140Abstract: A manufacturing method for manufacturing a spectacle lens is disclosed. The method includes: obtaining prescription data descriptive of an ophthalmic prescription of a user in the plus prescription range; obtaining frame data descriptive of a perimeter of a spectacle frame in which the lens is to be mounted; providing a lens blank having a convex front surface and a back surface; determining a final cutting surface to be machined on the back surface of the lens blank in a final cutting phase; and determining an intermediate cutting surface to be machined on the back surface of the lens blank in an initial cutting phase. Further, it is provided that the intermediate cutting surface is different from the final cutting surface; and the final cutting surface comprises a prescription zone in which the final cutting surface together with the front surface fulfills the ophthalmic prescription of the user.Type: GrantFiled: May 26, 2020Date of Patent: December 29, 2020Assignee: Carl Zeiss Vision International GmbHInventors: Ray Steven Spratt, Angela Nolan, Philipp Ellinger, Michael Gall
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Patent number: 10782541Abstract: The current invention is directed to a computer-implemented method for providing a lens shape for an ophthalmic lens. Further, there is provided a method for angular smoothing of a surface determined by carrier lines radially outwards of a prescription zone bordered by a first boundary line. Further, there is provided an ophthalmic lens, in particular a spectacle lens. Further, a method for minimizing the difference in thickness between two ophthalmic lenses for the same spectacles. A computer program product and a machine readable storage medium are provided as well.Type: GrantFiled: February 29, 2016Date of Patent: September 22, 2020Assignee: Carl Zeiss Vision International GmbHInventors: Ray Steven Spratt, Philipp Ellinger, Helmut Wietschorke, Angela Nolan, Saulius Varnas
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Patent number: 10775641Abstract: A computer-implemented method for providing a lens shape for an ophthalmic lens is disclosed. Further, there is provided a method for angular smoothing of a surface determined by carrier lines radially outwards of a prescription zone bordered by a first boundary line. In addition, there is provided an ophthalmic lens, in particular, a spectacle lens. Moreover, a method for minimizing the difference in thickness between two ophthalmic lenses for the same spectacles is provided. A computer program product and a machine-readable storage medium are provided as well.Type: GrantFiled: May 22, 2018Date of Patent: September 15, 2020Assignee: Carl Zeiss Vision International GmbHInventors: Ray Steven Spratt, Philipp Ellinger, Helmut Wietschorke, Angela Nolan, Saulius Varnas
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Patent number: 10775642Abstract: A computer-implemented method for providing a lens shape for an ophthalmic lens is disclosed. Further, there is provided a method for angular smoothing of a surface determined by carrier lines radially outwards of a prescription zone bordered by a first boundary line. In addition, there is provided an ophthalmic lens, in particular, a spectacle lens. Moreover, a method for minimizing the difference in thickness between two ophthalmic lenses for the same spectacles is provided. A computer program product and a machine-readable storage medium are provided as well.Type: GrantFiled: May 25, 2018Date of Patent: September 15, 2020Assignee: Carl Zeiss Vision International GmbHInventors: Ray Steven Spratt, Philipp Ellinger, Helmut Wietschorke, Angela Nolan, Saulius Varnas
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Publication number: 20200282507Abstract: A manufacturing method for manufacturing a spectacle lens is disclosed. The method includes: obtaining prescription data descriptive of an ophthalmic prescription of a user in the plus prescription range; obtaining frame data descriptive of a perimeter of a spectacle frame in which the lens is to be mounted; providing a lens blank having a convex front surface and a back surface; determining a final cutting surface to be machined on the back surface of the lens blank in a final cutting phase; and determining an intermediate cutting surface to be machined on the back surface of the lens blank in an initial cutting phase. Further, it is provided that the intermediate cutting surface is different from the final cutting surface; and the final cutting surface comprises a prescription zone in which the final cutting surface together with the front surface fulfills the ophthalmic prescription of the user.Type: ApplicationFiled: May 26, 2020Publication date: September 10, 2020Inventors: Ray Steven Spratt, Angela Nolan, Philipp Ellinger, Michael Gall
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Publication number: 20190258082Abstract: A computer-implemented method for providing a lens shape for an ophthalmic lens is disclosed. Further, there is provided a method for angular smoothing of a surface determined by carrier lines radially outwards of a prescription zone bordered by a first boundary line. In addition, there is provided an ophthalmic lens, in particular, a spectacle lens. Moreover, a method for minimizing the difference in thickness between two ophthalmic lenses for the same spectacles is provided. A computer program product and a machine-readable storage medium are provided as well.Type: ApplicationFiled: May 3, 2019Publication date: August 22, 2019Inventors: Ray Steven Spratt, Philipp Ellinger, Helmut Wietschorke, Angela Nolan, Saulius Varnas
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Publication number: 20190144847Abstract: Described herein are methods and means for reliably releasing maternal and/or paternal DNA from single seeds without substantially affecting the subsequent germination of the seeds. The methods are particularly suited for genome analysis of small grain cereals, including wheat. The methods may include enzymatic treatments for improved DNA recovery.Type: ApplicationFiled: March 29, 2017Publication date: May 16, 2019Inventors: Kristof Van der Meeren, Rainhard Koch, Philipp Ellinger, Nina Jansen, Stephen Rae, Martin Clausen
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Publication number: 20180275423Abstract: A computer-implemented method for providing a lens shape for an ophthalmic lens is disclosed. Further, there is provided a method for angular smoothing of a surface determined by carrier lines radially outwards of a prescription zone bordered by a first boundary line. In addition, there is provided an ophthalmic lens, in particular, a spectacle lens. Moreover, a method for minimizing the difference in thickness between two ophthalmic lenses for the same spectacles is provided. A computer program product and a machine-readable storage medium are provided as well.Type: ApplicationFiled: May 25, 2018Publication date: September 27, 2018Inventors: Ray Steven Spratt, Philipp Ellinger, Helmut Wietschorke, Angela Nolan, Saulius Varnas
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Publication number: 20180267330Abstract: A computer-implemented method for providing a lens shape for an ophthalmic lens is disclosed. Further, there is provided a method for angular smoothing of a surface determined by carrier lines radially outwards of a prescription zone bordered by a first boundary line. In addition, there is provided an ophthalmic lens, in particular, a spectacle lens. Moreover, a method for minimizing the difference in thickness between two ophthalmic lenses for the same spectacles is provided. A computer program product and a machine-readable storage medium are provided as well.Type: ApplicationFiled: May 22, 2018Publication date: September 20, 2018Inventors: Ray Steven Spratt, Philipp Ellinger, Helmut Wietschorke, Angela Nolan, Saulius Varnas
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Patent number: 9864212Abstract: The current invention is directed to a method, in particular a computer-implemented method, for providing a modified lens design for an uncut lens blank, in particular through the use of a non-transitory computer readable medium. Further, a method, in particular a computer-implemented method, for reducing a thickness of an original lens design of an uncut lens blank, in particular through the use of a non-transitory computer readable medium, is provided. Furthermore, a method for manufacturing an uncut lens blank and an uncut lens blank are provided.Type: GrantFiled: May 21, 2015Date of Patent: January 9, 2018Assignees: Carl Zeiss Vision International GmbH, Carl Zeiss Vision Inc.Inventors: Ray Steven Spratt, Timo Kratzer, Philipp Ellinger
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Publication number: 20170146818Abstract: The current invention is directed to a computer-implemented method for providing a lens shape for an ophthalmic lens. Further, there is provided a method for angular smoothing of a surface determined by carrier lines radially outwards of a prescription zone bordered by a first boundary line. Further, there is provided an ophthalmic lens, in particular a spectacle lens. Further, a method for minimizing the difference in thickness between two ophthalmic lenses for the same spectacles. A computer program product and a machine readable storage medium are provided as well.Type: ApplicationFiled: February 29, 2016Publication date: May 25, 2017Inventors: Ray Steven Spratt, Philipp Ellinger, Helmut Wietschorke, Angela Nolan, Saulius Varnas
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Publication number: 20150338680Abstract: The current invention is directed to a method, in particular a computer-implemented method, for providing a modified lens design for an uncut lens blank, in particular through the use of a non-transitory computer readable medium. Further, a method, in particular a computer-implemented method, for reducing a thickness of an original lens design of an uncut lens blank, in particular through the use of a non-transitory computer readable medium, is provided. Furthermore, a method for manufacturing an uncut lens blank and an uncut lens blank are provided.Type: ApplicationFiled: May 21, 2015Publication date: November 26, 2015Inventors: Ray Steven Spratt, Timo Kratzer, Philipp Ellinger
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Patent number: 8434025Abstract: A method of designing and/or selecting a progressive addition lens design for a wearer is disclosed. In an embodiment, the method includes displaying a graphical representation of an initial progressive addition lens design including design parameters having design values. A user interface is provided including, for each of one or more of the design parameters, a control that is adjustable over a range of levels, each level in the range being associated with a corresponding value of the respective design parameter. A control is adjusted to select a level and the selection is processed so as to substantially simultaneously update the displayed graphical representation in accordance with the selected level to provide a modified progressive lens design. A system for designing and/or selecting a progressive addition lens design for a wearer is also disclosed.Type: GrantFiled: November 15, 2006Date of Patent: April 30, 2013Assignee: Carl Zeiss Vision Australia Holdings LimitedInventors: Scott Warren Fisher, Saulius Raymond Varnas, Philipp Ellinger, Michael Alan Morris, Ray Steven Spratt, Timo Kratzer
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Publication number: 20080282183Abstract: A method of designing and/or selecting a progressive addition lens design for a wearer is disclosed. In an embodiment, the method includes displaying a graphical representation of an initial progressive addition lens design including design parameters having design values. A user interface is provided including, for each of one or more of the design parameters, a control that is adjustable over a range of levels, each level in the range being associated with a corresponding value of the respective design parameter. A control is adjusted to select a level and the selection is processed so as to substantially simultaneously update the displayed graphical representation in accordance with the selected level to provide a modified progressive lens design. A system for designing and/or selecting a progressive addition lens design for a wearer is also disclosed.Type: ApplicationFiled: November 15, 2006Publication date: November 13, 2008Applicant: CARL ZEISS VISION AUSTRALIA HOLDINGS LIMITEDInventors: Scott Warren Fisher, Saulius Raymond Varnas, Philipp Ellinger, Michael Alan Morris, Ray Steven Spratt, Timo Kratzer