Patents by Inventor Philipp Johannes Keller
Philipp Johannes Keller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230003987Abstract: An optical microscope apparatus includes: a sample interrogation system configured to probe a sample location; and a light collection system configured to collect light output from a sample due to being probed by the sample interrogation system. The light collection system includes: a mirror positioned along an imaging axis that passes through the sample location; and an optical lens system including a plurality of optical lenses arranged along the imaging axis, at least one of the lenses being a multiplet optical lens.Type: ApplicationFiled: June 17, 2020Publication date: January 5, 2023Inventors: Philipp Johannes Keller, Daniel Arthur Flickinger, Benquan Wang
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Publication number: 20220236550Abstract: A sample is imaged using light-sheet imaging. The light-sheet imaging includes generating light, forming one or more light sheets from the light at one or more positions within the sample along respective illumination directions that are parallel with an illumination axis, and recording images of fluorescence emitted along a detection direction from the sample due to the optical interaction between the one or more light sheets and the sample. One or more properties relating to the light-sheet imaging are measured; the one or more measured properties are analyzed; and one or more operating parameters associated with the light-sheet imaging are adjusted based on the analysis of the one or more measured properties.Type: ApplicationFiled: April 1, 2022Publication date: July 28, 2022Inventors: Philipp Johannes Keller, Raghav Kumar Chhetri, Loïc Alain Royer
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Patent number: 11320640Abstract: A sample is imaged using light-sheet imaging. The light-sheet imaging includes generating light, forming one or more light sheets from the light at one or more positions within the sample along respective illumination directions that are parallel with an illumination axis, and recording images of fluorescence emitted along a detection direction from the sample due to the optical interaction between the one or more light sheets and the sample. One or more properties relating to the light-sheet imaging are measured; the one or more measured properties are analyzed; and one or more operating parameters associated with the light-sheet imaging are adjusted based on the analysis of the one or more measured properties.Type: GrantFiled: June 23, 2017Date of Patent: May 3, 2022Assignee: Howard Hughes Medical InstituteInventors: Philipp Johannes Keller, Raghav Kumar Chhetri, Loïc Alain Royer
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Patent number: 10739266Abstract: A live biological specimen is imaged by generating a plurality of light sheets; directing the plurality of light sheets along an illumination axis through the biological specimen such that the light sheets spatially and temporally overlap within the biological specimen along an image plane, and optically interact with the biological specimen within the image plane; and recording, at each of a plurality of views, images of the fluorescence emitted along a detection axis from the biological specimen due to the optical interaction between the light sheets and the biological specimen. The temporal overlap is within a time shift that is less than a resolution time that corresponds to a spatial resolution limit of the microscope.Type: GrantFiled: February 28, 2018Date of Patent: August 11, 2020Assignee: Howard Hughes Medical InstituteInventor: Philipp Johannes Keller
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Patent number: 10539772Abstract: A method of imaging a live biological specimen includes generating one or more first light sheets; directing the generated one or more first light sheets along respective paths that are parallel with a first illumination axis such that the one or more first light sheets optically interact with at least a portion of the biological specimen in a first image plane; recording, at each of a plurality of first views, images of fluorescence emitted along a first detection axis; generating one or more second light sheets; directing the generated one or more second light sheets along respective paths that are parallel with a second illumination axis such that the one or more second light sheets optically interact with at least a portion of the biological specimen in a second image plane, and recording, at each of a plurality of second views, images of fluorescence emitted along a second detection axis.Type: GrantFiled: October 8, 2014Date of Patent: January 21, 2020Assignee: Howard Hughes Medical InstituteInventors: Philipp Johannes Keller, Raghav Kumar Chhetri
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Patent number: 10386302Abstract: A live biological specimen is imaged by generating a plurality of light sheets; directing the plurality of light sheets along an illumination axis through the biological specimen such that the light sheets spatially and temporally overlap within the biological specimen along an image plane, and optically interact with the biological specimen within the image plane; and recording, at each of a plurality of views, images of the fluorescence emitted along a detection axis from the biological specimen due to the optical interaction between the light sheets and the biological specimen. The temporal overlap is within a time shift that is less than a resolution time that corresponds to a spatial resolution limit of the microscope.Type: GrantFiled: February 10, 2016Date of Patent: August 20, 2019Assignee: Howard Hughes Medical InstituteInventor: Philipp Johannes Keller
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Publication number: 20190219811Abstract: A sample is imaged using light-sheet imaging. The light-sheet imaging includes generating light, forming one or more light sheets from the light at one or more positions within the sample along respective illumination directions that are parallel with an illumination axis, and recording images of fluorescence emitted along a detection direction from the sample due to the optical interaction between the one or more light sheets and the sample. One or more properties relating to the light-sheet imaging are measured; the one or more measured properties are analyzed; and one or more operating parameters associated with the light-sheet imaging are adjusted based on the analysis of the one or more measured properties.Type: ApplicationFiled: June 23, 2017Publication date: July 18, 2019Applicant: Howard Hughes Medical InstituteInventors: Philipp Johannes KELLER, Raghav Kumar CHHETRI, Loïc Alain ROYER
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Publication number: 20180188179Abstract: A live biological specimen is imaged by generating a plurality of light sheets; directing the plurality of light sheets along an illumination axis through the biological specimen such that the light sheets spatially and temporally overlap within the biological specimen along an image plane, and optically interact with the biological specimen within the image plane; and recording, at each of a plurality of views, images of the fluorescence emitted along a detection axis from the biological specimen due to the optical interaction between the light sheets and the biological specimen. The temporal overlap is within a time shift that is less than a resolution time that corresponds to a spatial resolution limit of the microscope.Type: ApplicationFiled: February 28, 2018Publication date: July 5, 2018Inventor: Philipp Johannes Keller
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Patent number: 9404869Abstract: A live biological specimen is imaged by generating a plurality of light sheets; directing the plurality of light sheets along an illumination axis through the biological specimen such that the light sheets spatially and temporally overlap within the biological specimen along an image plane, and optically interact with the biological specimen within the image plane; and recording, at each of a plurality of views, images of the fluorescence emitted along a detection axis from the biological specimen due to the optical interaction between the light sheets and the biological specimen. The temporal overlap is within a time shift that is less than a resolution time that corresponds to a spatial resolution limit of the microscope.Type: GrantFiled: October 9, 2013Date of Patent: August 2, 2016Assignee: Howard Hughes Medical InstituteInventor: Philipp Johannes Keller
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Publication number: 20160161410Abstract: A live biological specimen is imaged by generating a plurality of light sheets; directing the plurality of light sheets along an illumination axis through the biological specimen such that the light sheets spatially and temporally overlap within the biological specimen along an image plane, and optically interact with the biological specimen within the image plane; and recording, at each of a plurality of views, images of the fluorescence emitted along a detection axis from the biological specimen due to the optical interaction between the light sheets and the biological specimen. The temporal overlap is within a time shift that is less than a resolution time that corresponds to a spatial resolution limit of the microscope.Type: ApplicationFiled: February 10, 2016Publication date: June 9, 2016Inventor: Philipp Johannes Keller
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Publication number: 20150098126Abstract: A method of imaging a live biological specimen includes generating one or more first light sheets; directing the generated one or more first light sheets along respective paths that are parallel with a first illumination axis such that the one or more first light sheets optically interact with at least a portion of the biological specimen in a first image plane; recording, at each of a plurality of first views, images of fluorescence emitted along a first detection axis; generating one or more second light sheets; directing the generated one or more second light sheets along respective paths that are parallel with a second illumination axis such that the one or more second light sheets optically interact with at least a portion of the biological specimen in a second image plane, and recording, at each of a plurality of second views, images of fluorescence emitted along a second detection axis.Type: ApplicationFiled: October 8, 2014Publication date: April 9, 2015Inventors: Philipp Johannes Keller, Raghav Kumar Chhetri
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Publication number: 20140099659Abstract: A live biological specimen is imaged by generating a plurality of light sheets; directing the plurality of light sheets along an illumination axis through the biological specimen such that the light sheets spatially and temporally overlap within the biological specimen along an image plane, and optically interact with the biological specimen within the image plane; and recording, at each of a plurality of views, images of the fluorescence emitted along a detection axis from the biological specimen due to the optical interaction between the light sheets and the biological specimen. The temporal overlap is within a time shift that is less than a resolution time that corresponds to a spatial resolution limit of the microscope.Type: ApplicationFiled: October 9, 2013Publication date: April 10, 2014Inventor: Philipp Johannes Keller