Patents by Inventor Philipp KUHN
Philipp KUHN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20250082835Abstract: The invention relates to a blood treatment device configured to dephosphorylate extracellular adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and/or lipopolysaccharide (LPS) in the blood of a patient in need thereof in an extracorporeal blood circuit, wherein the device comprises a matrix having alkaline phosphatase (AP) immobilized thereon. The invention further relates to an extracorporeal blood circuit comprising a blood treatment device of the invention and to the blood treatment device for use as a medicament or to methods of treating an infection, preferably a blood or systemic infection, such as sepsis, and/or for the treatment of sepsis-associated acute kidney injury (AKI).Type: ApplicationFiled: November 26, 2024Publication date: March 13, 2025Inventors: Jan SWARTJES, Markus STORR, Martin REMPFER, Isabelle LITZINGER, Stefanie VOTTELER, Philipp KUHN
-
Patent number: 12215156Abstract: Disclosed herein are polypeptides, and methods of making and using such polypeptides, that comprise a bispecific antibody construct covalently linked to an extended recombinant polypeptide comprising a barcode fragment releasable from said polypeptide upon digestion by a protease, and a Release Segment that can be proteolytically cleaved wherein said cleavage releases the bispecific antibody construct from the extended recombinant polypeptide.Type: GrantFiled: October 25, 2023Date of Patent: February 4, 2025Assignee: Amunix Pharmaceuticals, Inc.Inventors: Volker Schellenberger, Eric Johansen, Angela Henkensiefken, Darragh Maccann, James McClory, Philipp Kuhn, Andre Frenzel, Bryan Irving, Mika Derynck
-
Publication number: 20250025614Abstract: A peritoneal dialysis (“PD”) system (10) including a PD machine (20); a patient line (50) extending from the PD machine (20); and a filter set (100) in fluid communication with the patient line (50), the filter set (100) including a filter body (110, 150, 190) housing first and second filter membranes (112a, 112b, such as a sterilizing grade or bacteria reduction filter membranes), the filter body (110, 150, 190) configured to be placed in different arrangements such that fresh PD fluid (i) flows through the first filter membrane (112a) and then through the second filter membrane (112b) or (ii) splits and flows through first and second filter membranes (112a, 112b) in parallel.Type: ApplicationFiled: November 21, 2022Publication date: January 23, 2025Inventors: Philipp KÜHN, Ralf FLIEG, Rainer BLICKLE, Steffen WAGNER
-
Publication number: 20250018101Abstract: A peritoneal dialysis (“PD”) system (10) includes a PD machine (20); a patient line (50) extending from the PD machine (20); and a filter set (100) in fluid communication with the patient line (50), the filter set (100) including a filter membrane (120, e.g., a sterilizing grade filter membrane or a bacteria reduction filter membrane) positioned and arranged such that fresh PD fluid flows through the filter membrane (120) into a filtered fluid compartment (106f), wherein the filtered fluid compartment (106f) includes an outlet (1060) to a port (106p), and wherein the port (106p) is in fluid communication with a circumferential used PD fluid channel (106c) positioned and arranged to carry used PD fluid around the filter membrane (120) without contacting the filter membrane (120). A method for priming filter set (100) is also disclosed.Type: ApplicationFiled: November 21, 2022Publication date: January 16, 2025Inventors: Steffen WAGNER, Ralf FLIEG, Philipp KÜHN, Christof BECK, Rainer BLICKLE, Bernd KRAUSE
-
Patent number: 12186472Abstract: The invention relates to a blood treatment device configured to dephosphorylate extracellular adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and/or lipopolysaccharide (LPS) in the blood of a patient in need thereof in an extracorporeal blood circuit, wherein the device comprises a matrix having alkaline phosphatase (AP) immobilized thereon. The invention further relates to an extracorporeal blood circuit comprising a blood treatment device of the invention and to the blood treatment device for use as a medicament or to methods of treating an infection, preferably a blood or systemic infection, such as sepsis, and/or for the treatment of sepsis-associated acute kidney injury (AKI).Type: GrantFiled: March 6, 2020Date of Patent: January 7, 2025Assignee: GAMBRO LUNDIA ABInventors: Jan Swartjes, Markus Storr, Martin Rempfer, Isabelle Litzinger, Stefanie Votteler, Philipp Kuhn
-
Publication number: 20250002576Abstract: Disclosed herein are antibodies and antibody fragments capable of binding to claudin 18.2.Type: ApplicationFiled: October 25, 2022Publication date: January 2, 2025Inventors: Philipp Kuhn, André Frenzel
-
Publication number: 20240400696Abstract: Provided herein are, inter alia, antibody binding domains for cluster of differentiation 3 T cell receptor (CD3), antibody binding domains for epidermal growth factor receptor (EGFR), cleavable linker sequences, and protease-activatable bispecific fusion proteins such as protease-activatable T cell engagers, as well as uses and methods of treatment.Type: ApplicationFiled: April 16, 2024Publication date: December 5, 2024Inventors: Viktoriya Dubrovskaya, Eric Johansen, Sina Khorsand, Lucas Liu, Volker Schellenberger, Milton To, Tracy Young, André Frenzel, Philipp Kuhn
-
Publication number: 20240076378Abstract: Disclosed herein are polypeptides, and methods of making and using such polypeptides, that comprise a bispecific antibody construct covalently linked to an extended recombinant polypeptide comprising a barcode fragment releasable from said polypeptide upon digestion by a protease, and a Release Segment that can be proteolytically cleaved wherein said cleavage releases the bispecific antibody construct from the extended recombinant polypeptide.Type: ApplicationFiled: October 25, 2023Publication date: March 7, 2024Inventors: Volker SCHELLENBERGER, Eric JOHANSEN, Angela HENKENSIEFKEN, Darragh MACCANN, James MCCLORY, Philipp KUHN, Andre FRENZEL, Bryan IRVING, Mika DERYNCK
-
Publication number: 20240059758Abstract: The present invention is related to antibodies and antigen-binding fragments of antibodies that specifically bind the SARS-CoV-2 glycoprotein S (spike) as well as diagnostic and therapeutic methods of using those antibodies.Type: ApplicationFiled: May 19, 2021Publication date: February 22, 2024Inventors: André Frenzel, Philipp Kuhn, Jonas Kügler, Michael Hust, Stefan Dübel, Doris Meier, Federico Bertoglio, Maren Schubert, Stephan Steinke, Marlies Becker, Viola Fühner, Maximilian Ruschig, Philip Alexander Heine, Kai-Thomas Schneider, Rico Ballmann, Susanne Zock-Emmenthal, Kristian Daniel Ralph Roth, Nora Langreder
-
Publication number: 20230322922Abstract: Disclosed herein are polypeptides, and methods of making and using such polypeptides, that comprise a bispecific antibody construct covalently linked to an extended recombinant polypeptide comprising a barcode fragment releasable from said polypeptide upon digestion by a protease, and a Release Segment that can be proteolytically cleaved wherein said cleavage releases the bispecific antibody construct from the extended recombinant polypeptide.Type: ApplicationFiled: December 10, 2022Publication date: October 12, 2023Inventors: Volker SCHELLENBERGER, Eric JOHANSEN, Angela HENKENSIEFKEN, Darragh MACCANN, James MCCLORY, Philipp KUHN, Andre FRENZEL, Milton TO, Michael FOX, Bryan IRVING, Mika DERYNCK
-
Publication number: 20220241484Abstract: The invention relates to a blood treatment device configured to dephosphorylate extracellular adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and/or lipopolysaccharide (LPS) in the blood of a patient in need thereof in an extracorporeal blood circuit, wherein the device comprises a matrix having alkaline phosphatase (AP) immobilized thereon. The invention further relates to an extracorporeal blood circuit comprising a blood treatment device of the invention and to the blood treatment device for use as a medicament or to methods of treating an infection, preferably a blood or systemic infection, such as sepsis, and/or for the treatment of sepsis-associated acute kidney injury (AKI).Type: ApplicationFiled: March 6, 2020Publication date: August 4, 2022Inventors: Jan SWARTJES, Markus STORR, Martin REMPFER, Isabelle LITZINGER, Stefanie VOTTELER, Philipp KUHN
-
Publication number: 20210061908Abstract: The invention is based on the surprising finding of antibodies that bind to IGSF11 (VSIG3) can also inhibit the interaction between IGSF11 and IGSF11 receptors such as VSIR(VISTA), the inhibition of such interaction can sensitise tumour cells to anti-tumour immune responses. In particular, the invention provides products, compositions and methods for treating diseases using modulators of IGSF11, especially antigen binding proteins targeting IGSF11, including those being inhibitors of IGSF11-interaction with VSIR. Also provided are methods of sensitising cells involved with a proliferative disorder against the cytotoxic effect of cell-mediated immune responses, and/or to kill such cells and/or methods for treating proliferative diseases, using an IGSF11 inhibitor such as an IGSF11-binding antibody, as well as certain related aspects including detection, diagnostic and screening methods.Type: ApplicationFiled: January 7, 2019Publication date: March 4, 2021Inventors: Philipp BECKHOVE, Tillmann MICHELS, Ayse Nur MENEVSE, Anchana RATHINASAMY, Valentina VOLPIN, Nisit KHANDELWAL, Stefanie URLINGER, Jonas ZANTOW, Andre FRENZEL, Philipp KUHN, Sabrina GENSSLER
-
Publication number: 20210054077Abstract: This disclosure relates to compositions having an antibody binding fragment that specifically binds to CD3 or an epitope thereof. Some embodiments include compositions and antibody binding fragments with increased stability. Bispecific fusion proteins including such antibody-binding fragments are also disclosed.Type: ApplicationFiled: August 19, 2020Publication date: February 25, 2021Inventors: Volker Schellenberger, Philipp Kuhn, André Frenzel, Darragh MacCann, James McClory
-
Patent number: 10705252Abstract: A Paleo Event Table creator tool box is described which is induced and/or allows a user to spatially join a selected area of interest of the earth crust to one selected tectonic plate in a tectonic plate model, which selected tectonic plate has an overlap with the area of interest, and to sample a paleogeographic dataset relevant to the area of interest for a series of paleogeographic time steps. A graphical user interface is induced and/or allows the user to create a Paleo Event Table that displays the sampled paleogeographic dataset. The Paleo Event Table creator tool box is used for paleogeographic reconstruction of the earth crust in the area of interest and identifying information relevant for the area of interest.Type: GrantFiled: March 4, 2016Date of Patent: July 7, 2020Assignee: SHELL OIL COMPANYInventors: Philipp Kuhn, Malcolm Ross, Cornelis Wilhelmus Maria Van Oosterhout
-
Patent number: 10639142Abstract: A multicomponent intraocular lens implantable in an optical system of a human eye, comprising: a base component and a front component, the front component comprising an attachment tab which extends from a circumferential side of the optical portion of the front component and engages the flange for attaching the front component to the base component, wherein the attachment tab of the front component comprises a resilient projection that protrudes away from the optical portion beyond the flange, wherein a portion of the resilient projection is located at a non-overlapping position with respect to the haptic of the base component in a circumferential direction around the optical portions, wherein the portion of the resilient projection has a back surface which is located backwards from a front surface of the haptic of the base component in the thickness direction of the base component.Type: GrantFiled: July 5, 2017Date of Patent: May 5, 2020Assignee: INFINITEVISION OPTICSInventors: Ted Werblin, Philippe Kuhn
-
Publication number: 20180052253Abstract: A Paleo Event Table creator tool box is described which is induced and/or allows a user to spatially join a selected area of interest of the earth crust to one selected tectonic plate in a tectonic plate model, which selected tectonic plate has an overlap with the area of interest, and to sample a paleogeographic dataset relevant to the area of interest for a series of paleogeographic time steps. A graphical user interface is induced and/or allows the user to create a Paleo Event Table that displays the sampled paleogeographic dataset. The Paleo Event Table creator tool box is used for paleogeographic reconstruction of the earth crust in the area of interest and identifying information relevant for the area of interest.Type: ApplicationFiled: March 4, 2016Publication date: February 22, 2018Inventors: Philipp KUHN, Malcolm ROSS, Cornelis Wilhelmus Maria VAN OOSTERHOUT
-
Publication number: 20170296331Abstract: A multicomponent intraocular lens implantable in an optical system of a human eye, comprising: a base component and a front component, the front component comprising an attachment tab which extends from a circumferential side of the optical portion of the front component and engages the flange for attaching the front component to the base component, wherein the attachment tab of the front component comprises a resilient projection that protrudes away from the optical portion beyond the flange, wherein a portion of the resilient projection is located at a non-overlapping position with respect to the haptic of the base component in a circumferential direction around the optical portions, wherein the portion of the resilient projection has a back surface which is located backwards from a front surface of the haptic of the base component in the thickness direction of the base component.Type: ApplicationFiled: July 5, 2017Publication date: October 19, 2017Inventors: Ted WERBLIN, Philippe KUHN