Abstract: A clamping means system including a bearing device and clamping vices, which fit into the bearing device and respectively have on their base area machine coupling system and on their side faces and flanks a bearing receiving contour and a gripping receiving contour. The bearing receiving contour has the greatest play; the fit between the gripper and the gripper receiving contour is of moderate precision, while the precision of the machine coupling system is the greatest. The clear functional separation between the machine coupling system and the bearing receiving contour or gripper receiving contour allows a reliable low-cost system to be constructed. Furthermore, in the case of mixed partly automated systems, in which parts of the handling tasks are performed by the operator and other parts are performed by gripping robots, the handling is possible in an easy and intuitive way.

Abstract: Methods and devices are disclosed relating improved articular models, implant components, and related guide tools and procedures. In addition, methods and devices are disclosed relating articular models, implant components, and/or related guide tools and procedures that include one or more features derived from patient-data, for example, images of the patient's joint. The data can be used to create a model for analyzing a patient's joint and to devise and evaluate a course of corrective action. The data also can be used to create patient-adapted implant components and related tools and procedures.

Abstract: The present invention describes methods, devices and instruments for resurfacing or replacing facet joints, uncovertebral joints and costovertebral joints. The joints can be prepared by smoothing the articular surface on one side, by distracting the joint and by implant insertion. Implants can be stabilized against a first articular surface by creating a high level of conformance with said first articular surface, while smoothing the second articular surface with a surgical instrument with a smooth mating implant surface.

Abstract: Disclosed herein are methods, compositions and tools for repairing articular surfaces repair materials and for repairing an articular surface. The articular surface repairs are customizable or highly selectable by patient and geared toward providing optimal fit and function. The surgical tools are designed to be customizable or highly selectable by patient to increase the speed, accuracy and simplicity of performing total or partial arthroplasty.

Abstract: Improved systems, methods, and devices for performing joint arthroplasty, including patient-adapted implant components and tools, as well as intraoperative measurement and optimization of joint kinematics are disclosed herein.

Abstract: Disclosed herein are methods, compositions and tools for repairing articular surfaces repair materials and for repairing an articular surface. The articular surface repairs are customizable or highly selectable by patient and geared toward providing optimal fit and function. The surgical tools are designed to be customizable or highly selectable by patient to increase the speed, accuracy and simplicity of performing total or partial arthroplasty.

Abstract: An embossing device that serves for preparation of a combined form-fit and friction-fit clamping of a workpiece in a respective clamping chuck. The embossing device includes jaws having embossing teeth that are formed on insertion bodies. The insertion bodies include a penetration edge respectively with which they penetrate into the workpiece surface in order to create a depression with defined dimensions. For this a workpiece contact surface is formed on the insertion body, preferably in the proximity to the bar-like projection that stops the penetration process of the bar-like projection as soon as the workpiece contact surface gets in contact with the workpiece surface during the execution of the embossing process. Then the force required for movement of the jaw increases considerably from which a control device generates a switch-off signal for the operation device.

Abstract: A workpiece clamping device having a first base body on which a first clamping body is slidably supported in a clamping direction, as well as a second base body on which a second clamping body is slidably supported in the clamping direction. The two clamping bodies are in engagement with a threaded spindle. A contact surface is provided on each base body on the side that faces the other base body respectively. The contact surfaces are arranged with base body distance in the clamping direction. A centering body of the threaded spindle has centering surfaces that abut at one assigned contact surface respectively in order to position the threaded spindle in clamping direction without clearance as far as possible.

Abstract: A workpiece clamping device having at least one base body. A first clamping body and a second clamping body are movably supported on the at least one base body in a clamping direction. A threaded spindle extends along a spindle longitudinal axis. The spindle longitudinal axis is orientated in clamping direction. It has a first thread section for the first clamping body and a second thread section for the second clamping body. A first coupling body has a first counter thread portion and a second coupling body has a second counter thread portion. In a coupling position the counter thread portions are in engagement with the assigned thread section respectively. In a decoupling position the counter thread portion is disengaged from the assigned thread section. In this decoupling position a movement of the clamping bodies is possible without rotation of the threaded spindle.

Abstract: Provided is a Coriolis flow sensor assembly that includes a flow tube configured to provide a flow path through the flow tube. Further, the Coriolis flow sensor assembly includes a mechanical drive assembly configured to drive an oscillation of the flow tube while fluid is flowing via an oscillation surface. The Coriolis flow sensor assembly includes an interface fixedly coupled to the oscillation surface of the mechanical drive assembly and configured to receive the flow tube.

Abstract: Provided is a Coriolis flow sensor assembly that includes a fluid flow assembly, including a flow tube, wherein the fluid flow assembly is configured to provide a flow path through the flow tube. The flow tube has at least one region of increased stiffness, which may be a result of a structural support component coupled to the flow tube. In another embodiment, the increased stiffness is caused by integral properties of the flow tube.

Abstract: Methods and devices for correcting wear pattern defects in joints. The methods and devices described herein allow for the restoration of correcting abnormal biomechanical loading conditions in a joint brought on by wear pattern defects, and also can, in embodiments, permit correction of proper kinematic movement.

Abstract: In a first aspect, the present invention relates to new recombinant artificial polypeptides allowing cytoplasmic signaling in cells containing the same. In particular, the present invention relates to a system for transmitting signals containing a recombinant polypeptide containing a domain with a first binding partner selected from an artificial ligand and a receptor binding an artificial ligand, a transmembrane domain and a cytoplasmic signaling domain whereby the domain with the binding partner and the cytoplasmic signaling domain are a combination of domains not naturally occurring in an organism and the second binding partner for specific forming of the binding pair. In a further aspect, a nucleic acid molecule comprising a nucleic acid sequence encoding the polypeptide according to the present invention as well as a vector, cell, cell line or host cell containing said vector are provided.

Abstract: A method of preparing an interpositional implant suitable for a knee. The method includes determining a three-dimensional shape of a tibial surface of the knee. An implant is produced having a superior surface and an inferior surface, with the superior surface adapted to be positioned against a femoral condyle of the knee, and the inferior surface adapted to be positioned upon the tibial surface of the knee. The inferior surface conforms to the three-dimensional shape of the tibial surface. The implant may be inserted into the knee without making surgical cuts on the tibial surface. The tibial surface may include cartilage, or cartilage and bone.

Abstract: Disclosed herein are tools for repairing articular surfaces repair materials and for repairing an articular surface. The surgical tools are designed to be customizable or highly selectable by patient to increase the speed, accuracy and simplicity of performing total or partial arthroplasty.

Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.

Abstract: Methods and devices for correcting wear pattern defects in joints. The methods and devices described herein allow for the restoration of correcting abnormal biomechanical loading conditions in a joint brought on by wear pattern defects, and also can, in embodiments, permit correction of proper kinematic movement.

Abstract: A method of joint arthroplasty includes obtaining an image of at least a portion of the tibial plateau. An outer periphery of at least a portion of the tibial plateau is derived based, at least in part, on the image. An implant is provided for the tibial plateau, the implant having a periphery that includes an outer edge that substantially matches the derived outer periphery of the tibial plateau.

Abstract: This application relates to hip replacement systems and methods. Disclosed include patient-adapted (patient-specific or patient-engineered) hip replacement systems including patient-adapted implants and patient-adapted surgical instrumentation. Related methods of making and using the systems are also disclosed.

Abstract: A Coriolis flow meter for measuring one or more properties of a fluid is described herein which involves a modular configuration, and includes a fluid flow sub-system and a mechanical oscillator sub-system, both functionally separate, and are coupled in a closed loop arrangement, such that the flow conduit is not directly vibrated, and instead receives induced oscillations from the mechanical oscillator sub-system. The Coriolis flow meter is useful for high purity applications, as well as for the bioprocessing applications. Bioprocessing systems incorporating the Coriolis flow meter are also described herein. Method for measuring one or more properties of a fluid using the disclosed Coriolis flow meter are also described herein.