Patents by Inventor Philipp Lehr

Philipp Lehr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3,4-dihydro-benzo[e][1,3]oxazin-2-ones
    Patent number: 7795251
    Abstract: The present invention relates 3,4-dihydro-benzo[e][1,3]oxazin-2-ones which are substituted at the nitrogen atom by unsubstituted or substituted (C1-8)alkyl, (C3-8)cycloalkyl, (C3-8)cycloalkyl(C1-4)alkyl, (C6-18)aryl or (C6-18)aryl(C1-4)alkyl and their use as pharmaceuticals.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: September 14, 2010
    Assignee: Novartis AG
    Inventors: Andreas Billich, Hubert Gstach, Philipp Lehr
  • N-arylsulfonyl-2,3-dihydro-1H-indoles and the use thereof as CCR9 inhibitors
    Patent number: 7781481
    Abstract: N-(benzenesulphonyl)-2,3-dihydro-1H-indols, wherein the indol is substituted by cyano, carboxy or alkylcarbonyloxy and their use as therapeutical agents.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: August 24, 2010
    Assignee: Novartis AG
    Inventors: Jose M. Carballido Herrera, Herbert Jaksche, Philipp Lehr, Gudrun Werner, Anthony Winiski
  • Inhibitors of CCR9 activity
    Patent number: 7759390
    Abstract: Compounds of formula I, wherein one of R1 and R2 is thienyl which is substituted by halogen and the other of R1 and R2 is substituted phenyl, wherein the substituents are as defined in the claims, with the proviso that the phenyl group is substituted by at least a cyano, carboxy or (C1-4)alkyloxycarbonyl group, are inhibitors of CCR9 activity and useful for therapeutic treatment.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: July 20, 2010
    Assignee: Novartis AG
    Inventors: Jose M. Carballido Herrera, Herbert Jaksche, Philipp Lehr, Gudrun Werner, Anthony Winiski
  • Pharmaceutically Active Benzensulphonyl-Indols
    Publication number: 20100075963
    Abstract: 1-Benzenesulfonyl-1H-indoles, processes for their production and their use as pharmaceuticals, e.g. in the treatment of disorders which are mediated by CCR9, such as e.g. inflammatory bowel disease.
    Type: Application
    Filed: February 4, 2008
    Publication date: March 25, 2010
    Applicant: NOVARTIS AG
    Inventors: Philipp Lehr, Anthony Winiski
  • Piperidine-4-acrylamides
    Publication number: 20100048633
    Abstract: A compound of formula (I), wherein substituents are as given above, useful in the treatment of a disease mediated by the action of CCR3.
    Type: Application
    Filed: January 29, 2008
    Publication date: February 25, 2010
    Inventors: Philipp Lehr, Klaus Weigand, Anny-Odile Colson
  • 3,4-DIHYDRO-BENZO[E][1,3]OXAZIN-2-ONES
    Publication number: 20090156588
    Abstract: The present invention relates 3,4-dihydro-benzo[e][1,3]oxazin-2-ones which are substituted at the nitrogen atom by unsubstituted or substituted (C1-8)alkyl, (C3-8)cycloalkyl, (C3-8)cycloalkyl(C1-4)alkyl, (C6-18)aryl or (C6-18)aryl(C1-4)alkyl and their use as pharmaceuticals.
    Type: Application
    Filed: April 13, 2006
    Publication date: June 18, 2009
    Inventors: Andreas Billich, Hubert Gstach, Philipp Lehr
  • Piperazinyl-or piperidinylamine-sulfamic acid amides as inhibitors of steroid sulfatase
    Publication number: 20090042899
    Abstract: Piperazinyl- or piperidinylamine-sulfamic acid amides and their use for the manufacture of a medicament in diseases mediated by the action of steroid sulfatase.
    Type: Application
    Filed: September 16, 2008
    Publication date: February 12, 2009
    Inventor: Philipp Lehr
  • Acylsulfonamides as inhibitors of steroid sulfatase
    Patent number: 7482462
    Abstract: A compound of formula wherein R1 is haloalkyl, alkenyl, phenyl, thienyl, pyridine, benzthiazolyl, chromanyl (1,2-dihydrobenzopyranyl) or (C6-18)aryl, and R1 or R2 independently of each other are substituted (C4-8)cycloalkyl, a substituted bridged cycloalkyl system, substituted piperidine, substituted tetrahydropyridine, or a substituted bridged heterocyclic system, useful as a pharmaceutical.
    Type: Grant
    Filed: October 4, 2002
    Date of Patent: January 27, 2009
    Inventors: Amarylla Horvath, Philipp Lehr, Peter Nussbaumer, Erwin Paul Schreiner
  • Inhibitors of Ccr9 Activity
    Publication number: 20080312313
    Abstract: A compound of formula (I), wherein the residues have various meanings, useful as pharmaceuticals.
    Type: Application
    Filed: December 22, 2006
    Publication date: December 18, 2008
    Inventors: Jose M. Carballido Herrera, Herbert Jaksche, Philipp Lehr, Gudrun Werner, Anthony Winiski
  • Modulators of Chemokine Receptor Activity
    Publication number: 20080306067
    Abstract: A compound of formula (I), wherein substituents are as given above, useful in the treatment of a disease mediated by the action of CCR3, in particular inflammatory or obstructive airway diseases.
    Type: Application
    Filed: October 23, 2006
    Publication date: December 11, 2008
    Inventors: Klaus Weigand, Thomas Ullrich, Kate Hoeganauer, Philipp Lehr, Rohan Beckwith
  • Inhibitors of Ccr9 Activity
    Publication number: 20080300295
    Abstract: Compounds of formula I, wherein one of R1 and R2 is thienyl which is substituted by halogen and the other of R1 and R2 is substituted phenyl, wherein the substituents are as defined in the claims, with the proviso that the phenyl group is substituted by at least a cyano, carboxy or (C1-4)alkyloxycarbonyl group, are inhibitors of CCR9 activity and useful for therapeutic treatment.
    Type: Application
    Filed: December 22, 2006
    Publication date: December 4, 2008
    Inventors: Jose M. Carballido Herrera, Herbert Jaksche, Philipp Lehr, Gudrun Werner, Anthony Winiski
  • Inhibitors of Ccr9 Activity
    Publication number: 20080275114
    Abstract: Compounds of formula (I), in which R1 and R2 are independently a substituted phenyl group, where the substituents are as defined in the claims and with the proviso that at least one of the substituents is a cyano, carboxy or (C1-4)alkoxycarbonyl group, are inhibitors of CCR9 activity useful for therapeutic treatment, particularly of irritable bowel disease.
    Type: Application
    Filed: December 22, 2006
    Publication date: November 6, 2008
    Inventors: Jose M. Carballido Herrera, Herbert Jaksche, Philipp Lehr, Gudrun Werner, Anthony Winiski
  • Inhibitors of Ccr9 Activity
    Publication number: 20080269312
    Abstract: N-(benzenesulphonyl)-2,3-dihydro-1H-indols, wherein the indol is substituted by cyano, carboxy or alkylcarbonyloxy and their use as therapeutical agents.
    Type: Application
    Filed: December 12, 2006
    Publication date: October 30, 2008
    Inventors: Jose M. Carballido Herrera, Herbert Jaksche, Philipp Lehr, Gudrun Werner, Anthony Winiski
  • Piperazinyl-or piperidinylamine-sulfamic acid amides as inhibitors of steroid sulfatase
    Patent number: 7439362
    Abstract: Piperazinyl- or piperidinylamine-sulfamic acid amides and their use for the manufacture of a medicament in diseases mediated by the action of steriod sulfatase.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: October 21, 2008
    Assignee: Novartis AG
    Inventor: Philipp Lehr
  • Use of Fused Imidazole Derivatives to Mediate Ccr3 Related Conditions
    Publication number: 20080207718
    Abstract: The use of compound of formula I in the preparation of a medicament, e.g. for the treatment of condition mediated by CCR3.
    Type: Application
    Filed: August 31, 2006
    Publication date: August 28, 2008
    Inventors: Rohan Beckwith, Kate Hoegenauer, Jeremy Lee Jenkins, Philipp Lehr, Thomas Ullrich, Klaus Weigand
  • MIF-inhibitors
    Patent number: 7378416
    Abstract: 3,4-dihydro-benzo[e][1,3]oxazin-2-ones which are substituted at the nitrogen atom by unsubstituted or substituted (C3-8)cycloalkyl, (C1-4)alkyl(C3-8)cycloalkyl, (C6-18)aryl or (C6-18)aryl(C1-4)alkyl and their use as pharmaceuticals.
    Type: Grant
    Filed: October 19, 2005
    Date of Patent: May 27, 2008
    Inventors: Andreas Billich, Philipp Lehr, Hubert Gstach
  • MIF-INHIBITORS
    Publication number: 20070219189
    Abstract: 3,4-dihydro-benzo[e][1,3]oxazin-2-ones which are substituted at the nitrogen atom by unsubstituted or substituted (C3-8)cycloalkyl, (C1-4)alkyl(C3-8)cycloalkyl, (C6-18)aryl or (C6-18)aryl(C1-4)alkyl and their use as pharmaceuticals.
    Type: Application
    Filed: October 19, 2005
    Publication date: September 20, 2007
    Inventors: Andreas Billich, Philipp Lehr, Hubert Gstach
  • Piperazinyl-or piperidinylamine-sulfamic acid amides as inhibitors of steroid sulfatase
    Publication number: 20060052393
    Abstract: Piperazinyl- or piperidinylamine-sulfamic acid amides and their use for the manufacture of a medicament in diseases mediated by the action of steriod sulfatase.
    Type: Application
    Filed: March 27, 2003
    Publication date: March 9, 2006
    Inventor: Philipp Lehr
  • Acylsulfonamides as inhibitors of steroid sulfatase
    Publication number: 20050059712
    Abstract: A compound of formula wherein R1 is haloalkyl, alkenyl, phenyl, thienyl, pyridine, benzthiazolyl, chromanyl (1,2-dihydrobenzopyranyl) or (C6-18)aryl, and R1 or R2 independently of each other are substituted (C4-8)cycloalkyl, a substituted bridged cycloalkyl system, substituted piperidine, substituted tetrahydropyridine, or a substituted bridged heterocyclic system, useful as a pharmaceutical.
    Type: Application
    Filed: October 4, 2002
    Publication date: March 17, 2005
    Inventors: Amarylla Horvath, Philipp Lehr, Peter Nussbaumer, Erwin Schreiner
  • 2,4-diamino-3-hydroxycarboxylic acid derivatives
    Patent number: 5538997
    Abstract: The invention relates to compounds of formula I ##STR1## wherein the substituents have various significances. They can be prepared by conventional methods, e.g. coupling, substitution, deprotection or protection reactions.They possess interesting pharmacological properties and are thus indicated for use in the treatment of retroviral infections, particularly as HIV proteinase inhibitors.
    Type: Grant
    Filed: January 3, 1994
    Date of Patent: July 23, 1996
    Assignee: Sandoz Ltd.
    Inventors: Andreas Billich, Brigitte Charpiot, Peter Ettmayer, Hubert Gstach, Philipp Lehr, Dieter Scholz