Publication number: 20180180619
Abstract: The present invention relates to a method for diagnosing pancreatic cancer in a subject comprising the steps of: (a) determining in at least one sample of said subject the amounts of a group of diagnostic biomarkers comprising (i) at least one diagnostic amino acid, said diagnostic amino acid being proline, histidine or tryptophan, preferably, being proline; (ii) at least one diagnostic ceramide, said diagnostic ceramide being ceramide (d18:1,C24:0) or ceramide (d18:2,C24:0), preferably being ceramide (d18:1,C24:0); (iii) at least one diagnostic sphingomyelin, said diagnostic sphingomyelin being sphingomyelin (35:1), sphingomyelin (d17:1,C16:0), sphingomyelin (41:2) or sphingomyelin (d18:2,C17:0), preferably being sphingomyelin (35:1); and (iv) CA19-9; and (b) comparing said amounts of the diagnostic biomarkers with a reference, whereby pancreatic cancer is diagnosed.
Type:
Application
Filed:
June 24, 2016
Publication date:
June 28, 2018
Applicant:
METANOMICS HEALTH GMBH
Inventors:
Beate Kamlage, Regina Reszka, Philip Schatz, Martin Dostler, Susan Carvalho, Erik Peter, Philipp Mappes, Holger Kalthoff, Bodo Schniewind, Julia Mayerle, Marcus Lerch, Robert Gruetzmann, Christian Pilarsky