Abstract: The metal organic framework (MOF) MIL-100 (Al) can be produced in a process in which aluminum nitrate and trimesic acid are brought to react with one another in an alcohol/water mixture under the action of NH3 and/or an NH3-releasing compound under mild conditions.

Abstract: The present invention relates to the field of oncolytic viruses and in particular to a recombinant rhabdovirus, such as vesicular stomatitis virus encoding in its genome for a CD80 extracellular domain Fc-fusion protein. The invention is further directed to the use of the recombinant virus in the treatment of cancer, and also to methods for producing such viruses.

Abstract: A power semiconductor module. The power semiconductor module includes a circuit carrier and at least one semiconductor switch, in particular a semiconductor switch half-bridge, connected to the circuit carrier. The circuit carrier includes an electrically insulating layer, in particular a ceramic layer, and two electrically conductive layers which are separated from one another by an insulating region, in particular an insulating trench, and are both connected to the electrically insulating layer. The electrically conductive layers are both electrically connected to a switching path connection of the semiconductor switch. The power semiconductor module includes at least one metal shaped body, which is connected to the electrically conductive layer and configured to melt when the predetermined temperature is exceeded, to overcome the insulating region, and to connect the electrically conductive layers separated from one another by the insulating region electrically, in particular low-ohmically.

Abstract: The present invention relates to the field of oncolytic viruses and in particular to a recombinant rhabdovirus, such as vesicular stomatitis virus encoding in its genome for a CD80 extracellular domain Fc-fusion protein. The invention is further directed to the use of the recombinant virus in the treatment of cancer, and also to methods for producing such viruses.

Abstract: A switch cabinet arrangement having at least one housing and at least one electrochemical energy storage accommodated therein and an extinguishing system, wherein at least one gas-permeable membrane is arranged in each case on at least two outer walls of the at least one housing, diametrically opposite one another, via which a gas atmosphere in the interior of the at least one housing is fluidically connected to a gas atmosphere in the surroundings of the at least one housing.

Abstract: This invention relates to IL-12 Fc fusion proteins and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of cancer.

Abstract: A cascade arrangement and to a semiconductor module. The cascode arrangement includes: a substrate, a JFET, a MOSFET, and at least one sensor system. A drain terminal of the MOSFET is electrically connected to a source terminal of the JFET and a source terminal of the MOSFET is electrically connected to a gate terminal of the JFET. A first semiconductor layer in which the MOSFET is formed and a second semiconductor layer in which the JFET is formed, are situated stacked on top of one another via a connecting material. Both an electrical and a thermal coupling between the JFET and the MOSFET are implemented via the connecting material. The stacked semiconductor layers are situated on the substrate. The first semiconductor layer includes a first subarea in which the MOSFET is formed and at least one second subarea in which the at least one sensor system is formed.

Abstract: The present invention relates to the field of oncolytic viruses and in particular to a recombinant rhabdovirus, such as vesicular stomatitis virus encoding in its genome for a CCL21 protein. The invention is further directed to the use of the recombinant virus in the treatment of cancer, and also to methods for producing such viruses.

Abstract: A drive train has a hydrodynamic retarder including a rotating bladed rotor and bladed stator, forming a working chamber for hydrodynamic transmission of power from rotor to stator, a power input feeding drive power to the retarder, and a synchronized separating clutch connected between power input and rotor. The clutch has two clutch halves, friction elements contacting each other and mechanical blocking elements. The friction elements equalize rotational speed between clutch halves, and the blocking elements form-lockingly connect the clutch halves. The clutch has an actuator displaceable along a displacement travel, over a first distance bringing the friction elements into mutual contact, and a second distance adjoining the first distance to synchronize the friction elements and rotational speed for locking with the blocking elements. At least one displacement sensor directly or indirectly detects displacement travel by the actuator and/or position of the actuator on the displacement travel.

Abstract: A polymer having a backbone chain, wherein the backbone chain includes linear amide linkages and nitrogen-atom-containing heteromonocyclic moieties, wherein the backbone chain is free of peptide linkages or wherein the backbone chain has a proportion of peptide linkages of maximum 30%, based on a total number of the linear amide linkages of the backbone chain, and wherein the nitrogen-atom-containing heteromonocyclic moieties have a proportion of 5% by weight to 25% by weight, based on the total weight of the polymer, is provided. A product or article and the use of the polymer for manufacturing or producing the product or article are further provided.

Abstract: The present invention relates to the field of oncolytic viruses and in particular to a recombinant rhabdovirus, such as vesicular stomatitis virus encoding in its genome for a CCL21 protein. The invention is further directed to the use of the recombinant virus in the treatment of cancer, and also to methods for producing such viruses.

Abstract: The present disclosure relates to an injection device for administering of a dose of a medicament. The injection device includes a housing that configured to accommodates a cartridge filled with the medicament, a first component movable relative to the housing along the longitudinal direction between an initial position and a trigger position for dispensing of the dose of the medicament, a second component rotatable relative to the housing for at least one of setting of the dose or dispensing of the dose, a cavity provided in or formed by at least one of the first component and the second component, the cavity been sized to accommodate an electronic detector, and at least a first gasket fastened to one of the housing, the first component and the second component and configured to seal the cavity against ingress of impurities at least while the first component is in the initial position.

Abstract: An autonomous mobile outdoor ground treatment robot includes an at least upper-side outer contour and a display screen device. The at least upper-side outer contour includes a contour face in a plan view of the outdoor ground treatment robot. The display screen device comprises a display screen face. The size of the display screen face in plan view of the outdoor ground treatment robot is at least 5% of a size of the contour face.

Abstract: The present disclosure relates to a medicament delivery device comprising: a reservoir for medicament; a dispensing mechanism operable to dispense medicament from the reservoir, the dispensing mechanism comprising a sleeve configured to rotate during the dispensing of medicament and having a plurality of formations at an end of the sleeve; and a dosage measurement system comprising at least one mechanically actuated sensor configured such that, in use, rotation of the sleeve causes successive formations to engage the sensor such that the sensor detects rotation of the sleeve and a processor configured to determine a dosage dispensed from the medicament reservoir based on the detected rotation of the sleeve.

Abstract: A solenoid valve, for controlling a brake pressure of a wheel brake of a slip-regulatable hydraulic brake system for a motor vehicle, includes a valve element, valve insert, valve seat, spring device, electromagnetic actuator, and armature. The valve element is longitudinally movably positioned at least partially in the valve insert, positioned between the armature and the valve seat, and configured to interact with the valve seat. The spring device, in an assembled position, has a force component acting on the valve element in an opening direction with respect to the valve seat. The electromagnetic actuator is configured to act on the valve element in a closing direction with respect to the valve seat. The valve element has a contact surface operatively connecting the valve element and armature, and configured such that a central axis of the valve element and the contact surface form a non-rectangular intersection angle.

Abstract: A drive train has a hydrodynamic retarder including a rotating bladed rotor and bladed stator, forming a working chamber for hydrodynamic transmission of power from rotor to stator, a power input feeding drive power to the retarder, and a synchronized separating clutch connected between power input and rotor. The clutch has two clutch halves, friction elements contacting each other and mechanical blocking elements. The friction elements equalize rotational speed between clutch halves, and the blocking elements form-lockingly connect the clutch halves. The clutch has an actuator displaceable along a displacement travel, over a first distance bringing the friction elements into mutual contact, and a second distance adjoining the first distance to synchronize the friction elements and rotational speed for locking with the blocking elements. At least one displacement sensor directly or indirectly detects displacement travel by the actuator and/or position of the actuator on the displacement travel.

Abstract: The disclosure is directed to a cutting blade for a cutter head and includes a base body having a fastening arrangement for fastening the cutting blade to a cutter head as well as a blade edge. The base body and the blade edge are made of a biodegradable natural substance. Alternatively, the base body is made of a non-biodegradable plastic and the blade edge is made at least in part of a biodegradable material.

Abstract: The present invention relates to the field of oncolytic viruses and in particular to a recombinant rhabdovirus, such as vesicular stomatitis virus encoding in its genome for a CD80 extracellular domain Fc-fusion protein. The invention is further directed to the use of the recombinant virus in the treatment of cancer, and also to methods for producing such viruses.

Abstract: The metal organic framework (MOF) MIL-100(Al) can be produced in a process in which aluminum nitrate and trimesic acid are brought to react with one another in an alcohol/water mixture under the action of NH3 and/or an NH3-releasing compound under mild conditions.

Abstract: A chair, such as a conference or office chair, includes a seat support; a backrest support; a storage member formed as a force storage element; and a transmission coupling the seat support with the backrest support which allows a pivoting of the backrest support and the seat support between an upright position and a backwardly pivoted position according to a predetermined sequence of movements. The force storage element is coupled with the seat support and the backrest support such that the predetermined sequence of movements is facilitated and the storage member provides a force restoring in the upright position and wherein the flexibly elastic storage member forms in conjunction at least with a first articulated rotation point of the transmission a kinematic chain.