Patents by Inventor Philippa Radcliffe

Philippa Radcliffe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9738907
    Abstract: Provided is a multicistronic retroviral vector genome having a first nucleic acid sequence upstream of at least one internal regulatory element, such that the level of genomic RNA available for packaging in the absence of rev, or a functional equivalent thereof, is increased.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: August 22, 2017
    Assignee: Oxford BioMedica (UK) Limited
    Inventors: Philippa Radcliffe, James E. Miskin, Fraser J. Wilkes, Kyriacos A. Mitrophanous, Susan M. Kingsman
  • Publication number: 20090007284
    Abstract: A method of producing a transgenic cell comprising introducing into a cell a non-primate lentiviral expression vector comprising a nucleotide of interest (NOI). Also described is a method of producing a transgenic cell comprising introducing into a cell a lentiviral expression vector comprising a NOI capable of generating an antisense oligonucleotide, a ribozyme, an siRNA, a short hairpin RNA, a micro-RNA or a group 1 intron. Also described is a viral vector comprising a first nucleotide sequence, wherein said first nucleotide sequence comprises: (a) a second nucleotide sequence comprising an aptazyme; and (b) a third nucleotide sequence capable of generating a polynucleotide; wherein (a) and (b) are operably linked and wherein the aptazyme is activatable to cleave a transcript of the first nucleotide sequence such that said polynucleotide is generated.
    Type: Application
    Filed: January 14, 2008
    Publication date: January 1, 2009
    Inventors: Philippa Radcliffe, Kyriacos Mitrophanous, Michael Themis
  • Publication number: 20060281180
    Abstract: Provided is a lentiviral vector capable of delivering a nucleotide of interest (NOI) to a desired target site and wherein the NOI encodes the Factor VIII and the Factor VIII is expressed following delivery of the NOI to the desired target site.
    Type: Application
    Filed: April 25, 2006
    Publication date: December 14, 2006
    Inventors: Philippa Radcliffe, Fraser Wilkes, Susan Kingsman, Kyriacos Mitrophanous
  • Publication number: 20050106559
    Abstract: Provided is a multicistronic retroviral vector genome having a first nucleic acid sequence upstream of at least one internal regulatory element, such that the level of genomic RNA available for packaging in the absence of rev, or a functional equivalent thereof, is increased.
    Type: Application
    Filed: May 7, 2004
    Publication date: May 19, 2005
    Inventors: Philippa Radcliffe, James Miskin, Fraser Wilkes, Kyriacos Mitrophanous, Susan Kingsman
  • Publication number: 20040040052
    Abstract: A method of producing a transgenic cell comprising introducing into a cell a non-primate lentiviral expression vector comprising a nucleotide of interest (NOI). Also described is a method of producing a transgenic cell comprising introducing into a cell a lentiviral expression vector comprising a NOI capable of generating an antisense oligonucleotide, a ribozyme, an siRNA, a short hairpin RNA, a micro-RNA or a group 1 intron. Also described is a viral vector comprising a first nucleotide sequence, wherein said first nucleotide sequence comprises: (a) a second nucleotide sequence comprising an aptazyme; and (b) a third nucleotide sequence capable of generating a polynucleotide; wherein (a) and (b) are operably linked and wherein the aptazyme is activatable to cleave a transcript of the first nucleotide sequence such that said polynucleotide is generated.
    Type: Application
    Filed: April 24, 2003
    Publication date: February 26, 2004
    Applicant: Oxford BioMedica (UK) Limited
    Inventors: Philippa Radcliffe, Kyriacos Mitrophanous, Michael Themis
  • Publication number: 20030121062
    Abstract: A method of producing a transgenic cell comprising introducing into a cell a non-primate lentiviral expression vector comprising a nucleotide of interest (NOI).
    Type: Application
    Filed: February 26, 2002
    Publication date: June 26, 2003
    Applicant: Oxford BioMedica (UK) Limited
    Inventors: Philippa Radcliffe, Kyriacos Mitrophanous, Michael Themis