Abstract: A process is provided for recovering a first polyunsaturated fatty acid (PUFA) from a feed mixture including at least one additional fatty acid (e.g., a second fatty acid (FA)). The process optionally comprises: performing a main step of chromatographic separation using an aqueous organic eluent and collecting a first stream of eluent enriched in the first PUFA and a second stream of eluent enriched in the second FA; subjecting the second stream of eluent to a partial concentration step to obtain a concentrated portion including the second FA, and a depleted portion comprising eluent, but depleted of the second FA. The process also includes: at least partially recycling the depleted portion for use in the main step of chromatographic separation.

Abstract: A process is provided for recovering a first polyunsaturated fatty acid (PUFA) from a feed mixture including at least one additional fatty acid (e.g., a second fatty acid (FA)). The process optionally comprises: performing a main step of chromatographic separation using an aqueous organic eluent and collecting a first stream of eluent enriched in the first PUFA and a second stream of eluent enriched in the second FA; subjecting the second stream of eluent to a partial concentration step to obtain a concentrated portion including the second FA, and a depleted portion comprising eluent, but depleted of the second FA. The process also includes: at least partially recycling the depleted portion for use in the main step of chromatographic separation.

Abstract: A process is provided for recovering a first polyunsaturated fatty acid (PUFA) from a feed mixture including at least one additional fatty acid (e.g., a second fatty acid (FA)). The process optionally comprises: performing a main step of chromatographic separation using an aqueous organic eluent and collecting a first stream of eluent enriched in the first PUFA and a second stream of eluent enriched in the second FA; subjecting the second stream of eluent to a concentration step to obtain a concentrated portion including the second FA, and a depleted portion comprising eluent, but depleted of the second FA. The water-to-organic ratio of the depleted portion is lower than the water-to-organic ratio of the second stream of eluent. The process also includes: at least partially recycling the depleted portion for use in the main step of chromatographic separation.

Abstract: The invention relates to a cotyloid component of a hip prosthesis, said cotyloid component being hollow and in the form of a cup whose outer part has a thread allowing it to be fixed in the iliac bone, said thread being a discontinuous self-cutting double thread (20, 21), and said cotyloid component having a flattened upper pole (1), a coating that promotes osseointegration on its outer face (10), and a concave, substantially hemispherical and polished inner surface (11), characterized in that: (a) the pitch of the threads (20, 21) decreases from the upper pole (1) towards the equatorial periphery (3) of the cotyloid component, (b) the thicknesses of the threads (20, 21) increase from the upper pole (1) of the cotyloid component towards its periphery (3), (c) the crest of the threads (20, 21) is sharp towards the pole (1) of the cotyloid component and rounded or substantially trapezoidal towards the equatorial periphery (3) of the cotyloid component.

Abstract: The invention relates to a cotyloid component of a hip prosthesis, said cotyloid component being hollow and in the form of a cup whose outer part has a thread allowing it to be fixed in the iliac bone, said thread being a discontinuous self-cutting double thread (20, 21), and said cotyloid component having a flattened upper pole (1), a coating that promotes osseointegration on its outer face (10), and a concave, substantially hemispherical and polished inner surface (11), characterized in that: (a) the pitch of the threads (20, 21) decreases from the upper pole (1) towards the equatorial periphery (3) of the cotyloid component, (b) the thicknesses of the threads (20, 21) increase from the upper pole (1) of the cotyloid component towards its periphery (3), (c) the crest of the threads (20, 21) is sharp towards the pole (1) of the cotyloid component and rounded or substantially trapezoidal towards the equatorial periphery (3) of the cotyloid component.

Abstract: The present invention relates to a process for preparing optically pure (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol and pharmaceutically acceptable salts and solvates from a mixture of (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol and (?)-(2R,3R)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol. The process utilizes continuous chromatography, including techniques like Multi Column Chromatography (MCC), VARICOL, and Cyclojet.

Abstract: The invention concerns a method for multiple-column chromatographic spearation producing at least two fractions, comprsing the following steps: in output of the extract, zone 1, or the raffinate zone, zone III: (i) drawing at least part of the output flow of said zone; (ii) concentrationg said part; and (iii) re-injecting at least partly said concentrated part. The invention also concerns a device for implementing said method.

Abstract: A process for separating at least one component of a mixture in a set of closed-loop chromatographic columns is described, whereby the loop comprises at least one feedstock injection point, a raffinate draw-off point, an eluant injection point, and an extract draw-off point, in which a determination is made between an injection point and a draw-off point or vice-versa a chromatographic zone, and at the end of a given period of time, all of the injection and draw-off points are shifted by one column or column section in a given direction that is defined relative to that of the flow of a main fluid that circulates through the loop. During the period, the shifting of different injection and draw-off points of a column or column section is done at different times in such a way that the lengths of the zones that are defined by said different points are variable. The process is useful for the seperation particularly of stereoisumers for pharmaceuticals.