Patents by Inventor Philippe AFONSO

Philippe AFONSO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In vitro blood-brain barrier model
    Patent number: 10591466
    Abstract: The invention is in the domain of delivery of molecules to brain cells across the blood-brain barrier. The invention relates to a novel polypeptide-based carrier that allows the efficient delivery of an effector peptide, to neuron cells across the blood-brain barrier, and to methods for the production and testing of such carrier, including a model for testing the capacity of such molecule to cross the blood-brain barrier and/or the toxicity of molecules on the blood brain barrier and/or the capacity of molecules that have crossed to target human brain cells (e/g. neurons, astrocytes and microglial cells).
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: March 17, 2020
    Assignees: INSTITUT PASTEUR, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Christophe Prehaud, Monique Lafon, Pierre-Emmanuel Ceccaldi, Philippe Afonso, Pierre Lafaye
  • NEW IN VITRO BLOOD-BRAIN BARRIER MODEL
    Publication number: 20170241988
    Abstract: The invention is in the domain of delivery of molecules to brain cells across the blood-brain barrier. The invention relates to a novel polypeptide-based carrier that allows the efficient delivery of an effector peptide, to neuron cells across the blood-brain barrier, and to methods for the production and testing of such carrier, including a model for testing the capacity of such molecule to cross the blood-brain barrier and/or the toxicity of molecules on the blood brain barrier and/or the capacity of molecules that have crossed to target human brain cells (e/g. neurons, astrocytes and microglial cells).
    Type: Application
    Filed: September 9, 2015
    Publication date: August 24, 2017
    Inventors: Christophe PREHAUD, Monique LAFON, Pierre-Emmanuel CECCALDI, Philippe AFONSO, Pierre LAFAYE