Publication number: 20240309013
Abstract: The invention provides crystalline forms of 2?-(7,7-dimethyl-1?H,7H-spiro[furo[3,4-b]pyridine-5,4?-piperidin]-1?-yl)-1,3-dihydro-4?H-spiro[indene-2,5?-[1,3]oxazol]-4?-one, and a process for converting Form A to Form B for use in medicaments for treatment of anxiety, depression, irritability, impaired social interactions and psychomotor coordination, and other indications. The invention further provides processes to manufacture 2?-(7,7-dimethyl-1?H,7H-spiro[furo[3,4-b]pyridine-5,4?-piperidin]-1?-yl)-1,3-dihydro-4?H-spiro[indene-2,5?-[1,3]oxazol]-4?-one. Also disclosed are compounds useful as intermediates in the methods of the invention.
Type:
Application
Filed:
May 16, 2024
Publication date:
September 19, 2024
Applicant:
Hoffmann-La Roche Inc.
Inventors:
Jean-Michel ADAM, Stephan BACHMANN, Raphael BIGLER, Pascal DOTT, Serena Maria FANTASIA, Katja GROSSE-SENDER, Philippe JAMES, Paul SPURR, Juergen THUN, Sandro TONAZZI, Paolo TOSATTI