Patents by Inventor Philippe Barthelemy

Philippe Barthelemy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200181607
    Abstract: The present invention relates to tetramolecular parallel G-quadruplex-forming oligonucleotides. If G-quadruplexes are of prime importance in biology, their use is hampered by the propensity of G4-prone DNA molecules, in particular G4-prone DNA molecules of long size, to adopt many different G4 topological conformations or other alternative foldings. By introducing a lipid modification at the end of the oligonucleotide, the inventors succeeded in obtaining long tetramolecular parallel G-quadruplexes (tpG4). The present invention thus concerns an oligonucleotide modified by substitution at the 5? or the 3? end by a lipid moiety, wherein said oligonucleotide comprises a nucleic acid sequence of at least 10 nucleotides, said nucleic acid sequence including a series of at least 4 consecutive guanine residues located in the middle of said sequence.
    Type: Application
    Filed: June 1, 2018
    Publication date: June 11, 2020
    Inventors: Philippe BARTHELEMY, Arnaud GISSOT, Brune VIALET
  • Patent number: 10633409
    Abstract: The invention relates to bola-amphiphilic compounds and their uses for biomedical application. The invention particularly relates to the use of bola-amphiphilic compounds for providing low molecular weight gels (LMWG), useful, in particular, as culture media for animal or human cells, or as biocompatible material for biomedical applications.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: April 28, 2020
    Assignees: UNIVERSITE DE BORDEAUX, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Philippe Barthelemy, Michael Ramin, Laurent Latxague, Ananda Appavoo, Olivier Chassande, Camille Ehret
  • Patent number: 10633408
    Abstract: The invention relates to new nucleoside-lipid compounds with pH-sensitive dialkylorthoester chains, to the process for their preparation and to their uses, in particular their use for transportation or vectorization of at least one therapeutic agent.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: April 28, 2020
    Assignees: UNIVERSITE DE BORDEAUX, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Philippe Barthelemy, Khalid Oumzil
  • Publication number: 20190233460
    Abstract: The invention relates to bola-amphiphilic compounds and their uses for biomedical application. The invention particularly relates to the use of bola-amphiphilic compounds for providing low molecular weight gels (LMWG), useful, in particular, as culture media for animal or human cells, or as biocompatible material for biomedical applications.
    Type: Application
    Filed: January 18, 2019
    Publication date: August 1, 2019
    Inventors: Philippe BARTHELEMY, Michael RAMIN, Laurent LATXAGUE, Ananda APPAVOO, Olivier CHASSANDE, Camille EHRET
  • Patent number: 10343934
    Abstract: The present invention relates to the use of a supramolecular system in order to remove particles from a liquid medium containing same. According to the invention, the supramolecular system includes at least one molecule having a low molecular weight and/or an organic compound from living organisms, preferably from jellyfish, said compound being selected from among collagen, a polysaccharide, a proteoglycan or a mixture of two of said organic compounds, and said molecule having a low molecular weight and formula (I) as defined herein. The invention also relates to a method for removing particles from a liquid medium containing same. The invention is particularly suitable for use in water decontamination and biotechnology.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: July 9, 2019
    Assignee: UNIVERSITE DE BORDEAUX
    Inventors: Philippe Barthelemy, Alain Thiery, Amit Patwa
  • Patent number: 10227372
    Abstract: The invention relates to bola-amphiphilic compounds and their uses for biomedical application. The invention particularly relates to the use of bola-amphiphilic compounds for providing low molecular weight gels (LMWG), useful, in particular, as culture media for animal or human cells, or as biocompatible material for biomedical applications.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: March 12, 2019
    Assignees: UNIVERSITE DE BORDEAUX, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Philippe Barthelemy, Michael Ramin, Laurent Latxague, Ananda Appavoo, Olivier Chassande, Camille Ehret
  • Publication number: 20180118775
    Abstract: The invention relates to new nucleoside-lipid compounds with pH-sensitive dialkylorthoester chains, to the process for their preparation and to their uses, in particular their use for transportation or vectorization of at least one therapeutic agent.
    Type: Application
    Filed: May 19, 2016
    Publication date: May 3, 2018
    Inventors: Philippe BARTHELEMY, Khalid OUMZIL
  • Publication number: 20180116972
    Abstract: The invention relates to non-polymeric lipid-based nanocarrier compositions loaded with metal nanoparticles and at least one therapeutic agent, useful agents for transportation, vectorization, cellular delivery cellular targeting or cellular localization of at least one therapeutic agent.
    Type: Application
    Filed: April 20, 2016
    Publication date: May 3, 2018
    Inventors: Philippe BARTHELEMY, Khalid OUMZIL, Gisèle CLOFENT-SANCHE, Marie-Josée JACOBIN-VALAT, Jeanny LAROCHE-TRAINEAU, Stéphane MORNET, Karen GAUDIN, Abdelmajid NOUBHANI, Xavier-Fran?ois SANTARELLI
  • Publication number: 20170240583
    Abstract: The invention relates to bola-amphiphilic compounds and their uses for biomedical application. The invention particularly relates to the use of bola-amphiphilic compounds for providing low molecular weight gels (LMWG), useful, in particular, as culture media for animal or human cells, or as biocompatible material for biomedical applications.
    Type: Application
    Filed: October 6, 2015
    Publication date: August 24, 2017
    Inventors: Philippe BARTHELEMY, Michael RAMIN, Laurent LATXAGUE, Ananda APPAVOO, Olivier CHASSANDE, Camille EHRET
  • Patent number: 9707250
    Abstract: The present invention concerns an oligonucleotide modified by substitution at the 3? or the 5? end by a moiety comprising at least three saturated or unsaturated, linear or branched hydrocarbon chains comprising from 2 to 30 carbon atoms, and the use therefore as a medicament, in particular for use for treating cancer.
    Type: Grant
    Filed: June 5, 2014
    Date of Patent: July 18, 2017
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITÉ DE BORDEAUX, Université d' Aix-Marseille, Institut Jean Paoli & Irene Calmettes, Centre Régional de Lutte Contre le Cancer, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)
    Inventors: Philippe Barthelemy, Khalid Oumzil, Arnaud Gissot, Palma Rocchi, Julie Acunzo
  • Patent number: 9701962
    Abstract: The present invention concerns an oligonucleotide modified by substitution at the 3? or the 5? end by a moiety comprising at least one ketal functional group, wherein the ketal carbon of said ketal functional group bears two saturated or unsaturated, linear or branched, hydrocarbon chains comprising from 1 to 22 carbon atoms, and the use therefore as a medicament, in particular for use for treating cancer.
    Type: Grant
    Filed: June 5, 2014
    Date of Patent: July 11, 2017
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE DE BORDEAUX, UNIVERSITE D 'AIX-MARSEILLE, INSTITUT JEAN PAOLI & IRENE CALMETTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Philippe Barthelemy, Khalid Oumzil, Palma Rocchi, Julie Acunzo
  • Patent number: 9533049
    Abstract: The invention relates to a method for preparing nanoparticles based on functional amphiphilic molecules or macromolecules, optionally in the presence of at least one colipide, enabling the encapsulation of therapeutic agents, especially anti-tumoral agents, and the use thereof for the transport and vectorization of therapeutic agents, especially anti-tumoral agents.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: January 3, 2017
    Assignees: UNIVERSITE D'AIX-MARSEILLE, UNIVERSITE DE BORDEAUX, UNIVERSITÉ DE BOURGOGNE
    Inventors: Philippe Barthelemy, Michel Camplo, Nathalie Campins, Bruno Chauffert, Florence Bouyer
  • Publication number: 20160113957
    Abstract: The present invention concerns an oligonucleotide modified by substitution at the 3? or the 5? end by a moiety comprising at least three saturated or unsaturated, linear or branched hydrocarbon chains comprising from 2 to 30 carbon atoms, and the use therefore as a medicament, in particular for use for treating cancer.
    Type: Application
    Filed: June 5, 2014
    Publication date: April 28, 2016
    Inventors: Philippe BARTHELEMY, Khalid OUMZIL, Arnaud GISSOT, Palma ROCCHI, Julie ACUNZO
  • Publication number: 20160108398
    Abstract: The present invention concerns an oligonucleotide modified by substitution at the 3? or the 5? end by a moiety comprising at least one ketal functional group, wherein the ketal carbon of said ketal functional group bears two saturated or unsaturated, linear or branched, hydrocarbon chains comprising from 1 to 22 carbon atoms, and the use therefore as a medicament, in particular for use for treating cancer.
    Type: Application
    Filed: June 5, 2014
    Publication date: April 21, 2016
    Inventors: Philippe Barthelemy, Khalid Oumzil, Palma Rocchi, Julie Acunzo
  • Patent number: 9050268
    Abstract: The invention relates to novel functional amphiphilic molecule or macromolecule formulations with multiple compartments for transporting or targeting at least one therapeutic agent, in particular an antitumor agent, as well as to a method for preparing such formulations and to the use thereof.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: June 9, 2015
    Assignees: UNIVERSITE d'AIX-MARSEILLE, UNIVERSITE DE BORDEAUX
    Inventors: Philippe Barthelemy, Salim Khiati, Michel Camplo
  • Publication number: 20150076062
    Abstract: The present invention relates to the use of a supramolecular system in order to remove particles from a liquid medium containing same. According to the invention, the supramolecular system includes at least one molecule having a low molecular weight and/or an organic compound from living organisms, preferably from jellyfish, said compound being selected from among collagen, a polysaccharide, a proteoglycan or a mixture of two of said organic compounds, and said molecule having a low molecular weight and formula (I) as defined herein. The invention also relates to a method for removing particles from a liquid medium containing same. The invention is particularly suitable for use in water decontamination and biotechnology.
    Type: Application
    Filed: January 25, 2013
    Publication date: March 19, 2015
    Inventors: Philippe Barthelemy, Alain Thiery, Amit Patwa
  • Publication number: 20140308343
    Abstract: The invention relates to a method for preparing nanoparticles based on functional amphiphilic molecules or macromolecules, optionally in the presence of at least one colipide, enabling the encapsulation of therapeutic agents, especially anti-tumoral agents, and the use thereof for the transport and vectorization of therapeutic agents, especially anti-tumoral agents.
    Type: Application
    Filed: March 13, 2014
    Publication date: October 16, 2014
    Applicants: UNIVERSITE VICTOR SEGALEN BORDEAUX 2, UNIVERSITE DE LA MEDITERRANEE, UNIVERSITE DE BOURGOGNE
    Inventors: Philippe BARTHELEMY, Michel CAMPLO, Nathalie CAMPINS, Bruno CHAUFFERT, Florence BOUYER
  • Publication number: 20120070505
    Abstract: The invention relates to novel functional amphiphilic molecule or macromolecule formulations with multiple compartments for transporting or targeting at least one therapeutic agent, in particular an antitumor agent, as well as to a method for preparing such formulations and to the use thereof.
    Type: Application
    Filed: May 28, 2010
    Publication date: March 22, 2012
    Applicants: UNIVERSITE DE LA MEDITERRANEE, UNIVERSITE BORDEAUX SEGALEN
    Inventors: Philippe Barthelemy, Salim Khiati, Michel Camplo
  • Publication number: 20110059180
    Abstract: The invention relates to a method for preparing nanoparticles based on functional amphiphilic molecules or macromolecules, optionally in the presence of at least one colipide, enabling the encapsulation of therapeutic agents, especially anti-tumoral agents, and the use thereof for the transport and vectorisation of therapeutic agents, especially anti-tumoral agents.
    Type: Application
    Filed: November 28, 2008
    Publication date: March 10, 2011
    Inventors: Philippe Barthelemy, Michel Camplo, Nathalie Campins, Bruno Chauffert, Florence Bouyer
  • Patent number: 7507859
    Abstract: The present invention describes a synthetic non-viral vector composition for gene therapy and the use of such compositions for in vitro, ex vivo and/or in vivo transfer of genetic material. The invention proposes a pharmaceutical composition containing 1) a non-cationic amphiphilic molecule or macromolecule and its use for delivery of nucleic acids or 2) a cationic amphiphilic molecule or macromolecule that transforms from a cationic entity to an anionic, neutral, or zwitterionic entity by a chemical, photochemical, or biological reaction and its use for delivery of nucleic acids. Moreover this invention describes the use of these non-viral vector compositions in conjunction with a surface to mediate the delivery of nucleic acids. An additional embodiment is the formation of a hydrogel with these compositions and the use of this hydrogel for the delivery of genetic material. A further embodiment of this invention is the use of a change in ionic strength for the delivery of genetic material.
    Type: Grant
    Filed: June 16, 2004
    Date of Patent: March 24, 2009
    Assignee: Fifth Base LLC
    Inventors: Mark W. Grinstaff, Philippe Barthelemy, Carla Prata, Louis Moreau