Patents by Inventor Philippe Bastiaens

Philippe Bastiaens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzene disulfonamide for the treatment of cancer
    Patent number: 10913710
    Abstract: The present invention relates to novel substituted benzene disulfonamides, as well as pharmaceutical compositions containing at least one of these substituted benzene disulfonamides together with at least one pharmaceutically acceptable carrier, excipient and/or diluent. Said substituted benzene disulfonamides are binding to the prenyl binding pocket of PDE6? and therefore, are useful for the prophylaxis and treatment of cancer by inhibition of the binding of PDE6? to farnesylated Ras proteins and thereby, inhibition of oncogenic Ras signaling in cells.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: February 9, 2021
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V
    Inventors: Herbert Waldmann, Pablo Antonio Martin-Gago, Sandip Murarka, Christian Klein, Philippe Bastiaens, Alfred Wittinghofer, Eyad Kalawy Fansa
  • BENZENE DISULFONAMIDE FOR THE TREATMENT OF CANCER
    Publication number: 20190359563
    Abstract: The present invention relates to novel substituted benzene disulfonamides, as well as pharmaceutical compositions containing at least one of these substituted benzene disulfonamides together with at least one pharmaceutically acceptable carrier, excipient and/or diluent. Said substituted benzene disulfonamides are binding to the prenyl binding pocket of PDE6? and therefore, are useful for the prophylaxis and treatment of cancer by inhibition of the binding of PDE6? to farnesylated Ras proteins and thereby, inhibition of oncogenic Ras signaling in cells.
    Type: Application
    Filed: January 11, 2018
    Publication date: November 28, 2019
    Inventors: Herbert Waldmann, Pablo Antonio Martin-Gago, Sandip Murarka, Christian Klein, Philippe Bastiaens, Alfred Wittinghofer
  • METHODS, KITS AND MEANS FOR DETERMINING INTRACELLULAR INTERACTIONS
    Publication number: 20150064713
    Abstract: Methods, kits and systems for determining whether a reaction occurs between a chimeric transmembrane receptor and an intracellular interaction partner thereof within a cell.
    Type: Application
    Filed: September 3, 2013
    Publication date: March 5, 2015
    Inventors: Philippe Bastiaens, Stephanie Reisewitz, Giuseppe Arrabito, Leif Dehmelt, Silke Gandor, Hendrik Schroeder, Christof M. Niemeyer
  • DEVICE AND METHOD FOR PRESSURIZED CRYOPRESERVATION OF A BIOLOGICAL SAMPLE
    Publication number: 20140260346
    Abstract: A cryopreservation device (100) which is arranged for cryopreservation of a biological sample (1) comprises a pressure vessel (10) with a vessel wall (11) and an internal space (12) which is arranged to receive the biological sample (1), wherein the pressure vessel (10) is equipped with an actuating device (20) for cooling by lowering the temperature and raising the pressure in the pressure vessel (10) and configured for the cryopreservation of the biological sample (1). Said actuating device (20) is connected to the vessel wall (11) and comprises at least one pressure setting element (21-23, 31) and at least one of at least one cooling element (34) and at least one heat conducting element (35-38), wherein the actuating device (20) is configured for a time-dependent and/or location-dependent setting of the temperature and of the pressure in the pressure vessel (10).
    Type: Application
    Filed: October 10, 2012
    Publication date: September 18, 2014
    Applicants: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V., Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Guenter R. Fuhr, Heiko Zimmermann, Frank Stracke, Markus Grabenbauer, Jan Huebinger, Philippe Bastiaens, Frank Wehner