Abstract: Identification of small organic molecules capable of stimulating aerobic glycolysis and cone survival would lead to the conception of new therapies of the retinal degenerative diseases. Now the inventors identified Geralexin, an acetogenin, extracted from Uvaria chamae a medicinal plant and showed that the molecule can stimulate aerobic glycolysis and cone survival. Geralexin would be suitable for the treatment of retinal degenerative diseases in particular for Age-Related Macular Degeneration (AMD) by preventing cone outer segment shortening and maintaining central vision.

Abstract: A method of determining diffusion coefficient of one or more components in a polydisperse sample is provided. The method comprising the steps of: introducing an auxiliary fluid flow into a fractionation channel; introducing the polydisperse sample comprising one or more components into the fractionation channel; allowing the sample and the auxiliary fluid to create a combined flow; fractionating the combined flow into two or more fractions by diffusive sizing; subsequently separating two or more components from each fraction by creating a distribution of the components within a separation channel; detecting a characteristic of each the two or more components in each fraction; and comparing the characteristic of each component in each fraction in order to determine the diffusion coefficient of each of the one or more components in the polydisperse sample.

Abstract: The invention relates to a jewelry item (10) comprising:—at least one cable (12) arranged to form a support mesh (14),—a plurality of decorative elements (16) threaded on said at least one cable (12) and shaped to structure the support mesh (14) according to a predetermined three-dimensional profile. The invention also relates to a jewelry assembly comprising at least two jewelry items (10) according to any one of the preceding claims and means for securing the support meshes together.

Abstract: This invention relates to compounds that are inhibitors of NGAL activity, and applications thereof.

Abstract: A wake-up circuit and method are provided for detecting and preventing false positive wake-up events in an electronic device in a sleep mode. Methodology entails producing first, second, and third sensor signals at successive first, second, and third instants in time in response to a physical stimulus detected by a sensor of the wake-up circuit. The first sensor signal is selected to be a reference value. A first difference value is determined between the second sensor signal land the reference value, a second difference value is determined between the third sensor signal and the reference value, and communication of a wake-up signal to the electronic device is prevented when at least one of the first and second difference values fails to exceed a threshold value.

Abstract: The present invention relates to an inhibitor of miR-671-5p for use in a method of preventing or treating fibrosis. Further, the present invention encompasses a kit comprising said inhibitor of miR-671-5p. The present invention also relates to an in vitro method for identifying a compound for preventing or treating fibrosis.

Abstract: The invention relates to a jewelry item (10) comprising:—at least one cable (12) arranged to form a support mesh (14),—a plurality of decorative elements (16) threaded on said at least one cable (12) and shaped to structure the support mesh (14) according to a predetermined three-dimensional profile. The invention also relates to a jewelry assembly comprising at least two jewelry items (10) according to any one of the preceding claims and means for securing the support meshes together.

Abstract: The present invention relates to the cosmetic or pharmaceutical use for a composition comprising a salicylic or nicotinic acid derivative inhibiting chemokines, for preventing or treating chronic internal and/or external inflammatory conditions.

Abstract: A wake-up circuit and method are provided for detecting and preventing false positive wake-up events in an electronic device in a sleep mode. Methodology entails producing first, second, and third sensor signals at successive first, second, and third instants in time in response to a physical stimulus detected by a sensor of the wake-up circuit. The first sensor signal is selected to be a reference value. A first difference value is determined between the second sensor signal and the reference value, a second difference value is determined between the third sensor signal and the reference value, and communication of a wake-up signal to the electronic device is prevented when at least one of the first and second difference values fails to exceed a threshold value.

Abstract: Gas supply device, comprising a frame equipped with a base and accommodating a plurality of pressurised fluid cylinders connected to a fluidic circuit comprising a first connection end connected to the cylinders and a second end comprising at least one fluidic connection intended to be connected removably to an extraction or filling element for the cylinders, the frame comprising on one of its faces at least one opening giving access to at least one connection of the circuit, the frame also comprising at least one attachment element provided to cooperate with a lifting device.

Abstract: The present invention relates to an inhibitor of miR-671-5p for use in a method of preventing or treating fibrosis. Further, the present invention encompasses a kit comprising said inhibitor of miR-671-5p. The present invention also relates to an in vitro method for identifying a compound for preventing or treating fibrosis.

Abstract: A device for supplying pressurized fluid including a pressurized fluid cylinder, at least one first tap connected to the pressurized fluid cylinder, the tap including an internal fluid circuit including an isolation valve, the device including an electronic apparatus for the wireless remote communication of data via electromagnetic waves, the electronic communication apparatus including a communication element designed to communicate wirelessly using at least one of the following frequency-modulation and/or phase-modulation low-consumption and long-range communication technologies: LoRa communication technology, communication technology from Sigfox, where the device includes a protective cap mounted on the cylinder in order to protect the first tap and a second tap connected detachably to the first tap, and the electronic communication apparatus being situated either on the cylinder, on the cap, on the first tap, or on the second tap.

Abstract: The invention relates to a device for providing pressurized fluid. The device includes a first functional assembly including a pressurized fluid bottle having an opening having attached therein a first tap including an inner fluid circuit including an insulating valve. The device includes a second functional assembly forming a physical entity separate from the first assembly. The second assembly includes a second tap having an inner fluid circuit. The first tap and the second tap include respective coupling members forming a removable rapid connection system. The device includes in the first assembly at least one electronic data storage communication unit that is removably, wirelessly queryable via electromagnetic waves and in that the second assembly includes at least one electronic communication unit for removably, wirelessly reading, via electromagnetic waves, data from the electronic member of the first assembly.

Abstract: A method for voltage regulation includes reducing a power consumption of a voltage regulator during an IDLE phase, by disabling a feedback loop configured to regulate an internal voltage to a multiple of a reference voltage in response to the voltage regulator receiving a digital signal from a digital circuit. The internal voltage is proportional to an external voltage supplied to the digital circuit. A regulated accuracy of the external voltage is increased during a MEASUREMENT phase by enabling the feedback loop in response to the voltage regulator receiving the digital signal from the digital circuit.

Abstract: A method for voltage regulation includes reducing a power consumption of a voltage regulator during an IDLE phase, by disabling a feedback loop configured to regulate an internal voltage to a multiple of a reference voltage in response to the voltage regulator receiving a digital signal from a digital circuit. The internal voltage is proportional to an external voltage supplied to the digital circuit. A regulated accuracy of the external voltage is increased during a MEASUREMENT phase by enabling the feedback loop in response to the voltage regulator receiving the digital signal from the digital circuit.

Abstract: A differential-logic logic circuit chained with another differential-logic circuit comprises a first logic cell composed of back-gate transistors, the first cell having a first input for receiving a first input signal and having an output for delivering a first output signal, and a second logic cell complementary to the first cell, composed of back-gate transistors, the second cell having as many inputs as the first cell, each input able to receive an input signal complementary to the respective input signal of the first cell, the second cell having an output for delivering a second output signal complementary to the first output signal of the first cell. The first output signal of the first cell is applied to the back gate of each transistor of the second cell, and the second output signal of the second cell is applied to the back gate of each transistor of the first cell.

Abstract: A device for supplying pressurized fluid including a pressurized fluid cylinder, at least one first tap connected to the pressurized fluid cylinder, the tap including an internal fluid circuit including an isolation valve, the device including an electronic apparatus for the wireless remote communication of data via electromagnetic waves, the electronic communication apparatus including a communication element designed to communicate wirelessly using at least one of the following frequency-modulation and/or phase-modulation low-consumption and long-range communication technologies: LoRa communication technology, communication technology from Sigfox, where the device includes a protective cap mounted on the cylinder in order to protect the first tap and a second tap connected detachably to the first tap, and the electronic communication apparatus being situated either on the cylinder, on the cap, on the first tap, or on the second tap.

Abstract: Gas supply device, comprising a frame equipped with a base and accommodating a plurality of pressurised fluid cylinders connected to a fluidic circuit comprising a first connection end connected to the cylinders and a second end comprising at least one fluidic connection intended to be connected removably to an extraction or filling element for the cylinders, the frame comprising on one of its faces at least one opening giving access to at least one connection of the circuit, the frame also comprising at least one attachment element provided to cooperate with a lifting device.

Abstract: The present invention relates to the cosmetic or pharmaceutical use for a composition comprising a salicylic or nicotinic acid derivative inhibiting chemokines, for preventing or treating chronic internal and/or external inflammatory conditions.

Abstract: An electric field sensor includes sense and reference cells. The sense cell produces a resistance that varies relative to an intensity of an electric field, and the reference cell produces a resistance that is invariable relative to the intensity of the electric field. An output signal indicative of the intensity of the electric field is determined using the difference between the resistances. A system includes an electric field source that outputs a digital test program as an electric field signal. The system further includes the electric field sensor formed with IC dies on a wafer. The electric field sensor receives the electric field signal. The received electric field signal is converted to the test program, and the test program is stored in memory on the wafer. The electric field source does not physically contact the dies, but can flood an entire surface of the wafer with the electric field signal.