Patents by Inventor Philippe Bey

Philippe Bey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDES WITH ENHANCED STABILITY AND THEIR USE IN METHODS FOR TREATING DISEASES
    Publication number: 20160137714
    Abstract: The invention provides peptides that are useful for treating or preventing, or preventing the progression of a disorder associated with aberrant TDF polypeptide or TDFRP compound target molecule expression or activity, for example a kidney disease or disorder, in a subject. The invention also provides methods of treating a subject having a disorder associated with aberrant TDF polypeptide or TDFRP compound target molecule expression or activity, such as a kidney disease or disorder, comprising administering to the subject an effective amount of the peptides of the invention.
    Type: Application
    Filed: November 12, 2015
    Publication date: May 19, 2016
    Inventors: Peter C. KECK, Philippe BEY, Roger LEGER, Paul DROGARIS
  • TDF-RELATED COMPOUNDS AND ANALOGS THEREOF, ANALOGS AND BIOACTIVE FRAGMENTS
    Publication number: 20150126451
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Application
    Filed: November 5, 2014
    Publication date: May 7, 2015
    Inventors: William D. Carlson, Peter C. Keck, Michael Sworin, Dattatreyamurty Bosukonda, Kellie Watson, Philippe Bey, Romesh Subramanian
  • TDF-related compounds and analogs thereof, analogs and bioactive fragments
    Patent number: 8911953
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: December 16, 2014
    Assignee: Thrasos Innovation, Inc.
    Inventors: William D. Carlson, Peter C. Keck, Dattatreyamurty Bosukonda, Philippe Bey
  • TDF-RELATED COMPOUNDS AND ANALOGS THEREOF, ANALOGS AND BIOACTIVE FRAGMENTS
    Publication number: 20130231294
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Application
    Filed: September 20, 2012
    Publication date: September 5, 2013
    Inventors: William D Carlson, Peter C. Keck, Michael Sworin, Dattatreyamurty Bosukonda, Kellie Watson, Philippe Bey, Romesh Subramanian
  • TDF-related compounds and analogs thereof, analogs and bioactive fragments
    Patent number: 8299212
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Grant
    Filed: September 20, 2006
    Date of Patent: October 30, 2012
    Assignee: Thrasos Therapeutics, Inc.
    Inventors: William D. Carlson, Peter C. Keck, Dattatreymurty Bosukonda, Philippe Bey
  • TDF-RELATED COMPOUNDS AND ANALOGS THEREOF, ANALOGS AND BIOACTIVE FRAGMENTS
    Publication number: 20100209467
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Application
    Filed: September 20, 2006
    Publication date: August 19, 2010
    Applicant: Thrasos Therapeutics , Inc.
    Inventors: William D. Carlson, Peter C. Keck, Michael Sworin, Dattatreymurty Bosukonda, Kellie Watson, Philippe Bey, Romesh Subramanian
  • Peptidase inhibitors
    Patent number: 5736520
    Abstract: This invention relates to analogs of peptidase substrates in which the nitrogen atom of the scissile amide group of the substrate peptide has been replaced by H, an aldehyde, a substituted carbonyl or a substituted malonyl moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.
    Type: Grant
    Filed: May 4, 1995
    Date of Patent: April 7, 1998
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Philippe Bey, Michael R. Angelastro, Shujaath Mehdi
  • Method of controlling tumor growth rate
    Patent number: 5614557
    Abstract: .alpha.-Fluoromethyl- or .alpha.-difluoromethylornithine, and certain derivatives thereof, can be used alone or in combination with cytotoxic agents for the treatment of neoplastic diseases.
    Type: Grant
    Filed: March 14, 1995
    Date of Patent: March 25, 1997
    Assignee: Marion Merrell et Compagnie C/O Merrell Pharmaceuticals Inc.
    Inventors: Philippe Bey, Michel Jung
  • Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
    Patent number: 5527795
    Abstract: The present invention relates to certain novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and of ACE.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: June 18, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Philippe Bey, Alan M. Warshawsky, Douglas W. Beight, Shujaath Mehdi, Eugene L. Giroux, Timothy P. Burkholder, Edward D. Daugs, John F. French
  • Inhibitors of Cathepsin G and elastase for preventing connective tissue degradation
    Patent number: 5510333
    Abstract: Novel compounds which are chemically linked inhibitors of the proteases Elastase and Cathepsin G prevent connective tissue degradation associated with neutrophil induced inflammatory disease.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: April 23, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Michael R. Angelastro, Philippe Bey, Niall S. Doherty, Michael J. Janusz, Shujaath Mehdi, Norton P. Peet
  • Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE
    Patent number: 5491143
    Abstract: The present invention relates to certain novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and of ACE.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: February 13, 1996
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Philippe Bey, Alan M. Warshawsky, Douglas W. Beight, Shujaath Mehdi, Eugene L. Giroux, Timothy P. Burkholder, Edward D. Daugs, John F. French
  • Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
    Patent number: 5430145
    Abstract: The present invention relates to certain novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and of ACE.
    Type: Grant
    Filed: November 9, 1993
    Date of Patent: July 4, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Philippe Bey, Alan M. Warshawsky, Douglas W. Beight, Shujaath Mehdi, Eugene L. Giroux, Timothy P. Burkholder, Edward D. Daugs, John F. French
  • Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
    Patent number: 5286726
    Abstract: This invention relates to certain conjugates of folates and antifolates with difluoroglutamic acid which are useful in the treatment of patients suffering from certain neoplastic diseases including leukemia, melanomas, carcinomas, sarcomas and mixed neoplasias.
    Type: Grant
    Filed: April 12, 1990
    Date of Patent: February 15, 1994
    Assignees: The Regents of the University of Michigan, Health Research, Inc., Merrell Dow Pharmaceuticals Inc.
    Inventors: Philippe Bey, James K. Coward, John J. McGuire
  • Inhibitors of lysyl oxidase
    Patent number: 5252608
    Abstract: This invention relates to certain inhibitors of lysyl oxidase and their use in the treatment of diseases and conditions associated with the abnormal deposition of collagen.
    Type: Grant
    Filed: June 10, 1992
    Date of Patent: October 12, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Michael G. Palfreyman, Philippe Bey, Ian A. McDonald
  • Method of inhibiting protozoal growth
    Patent number: 5196450
    Abstract: This invention relates to the use of .alpha.- halomethyl, .alpha.-acetylenic or .alpha.-allenic derivatives of arginine and agmatine, or their dehydro analogs, in the treatment of Chagas disease and Coccidiosis.
    Type: Grant
    Filed: September 30, 1991
    Date of Patent: March 23, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert Sjoerdsma, Peter P. McCann, Philippe Bey, Patrick J. Casara
  • Inhibitors of lysyl oxidase
    Patent number: 5182297
    Abstract: This invention relates to certain inhibitors of lysyl oxidase and their use in the treatment of diseases and conditions associated with the abnormal deposition of collagen.
    Type: Grant
    Filed: March 6, 1991
    Date of Patent: January 26, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Michael G. Palfreyman, Philippe Bey, Ian A. McDonald
  • Inhibitors of lysyl oxidase
    Patent number: 5120764
    Abstract: This invention relates to certain inhibitors of lysyl oxidase and their use in the treatment of diseases and conditions associated with the abnormal deposition of collagen.
    Type: Grant
    Filed: November 1, 1988
    Date of Patent: June 9, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: James R. McCarthy, Charlotte L. Barney, Donald P. Matthews, Philippe Bey
  • Cyclopropyl squalene derivatives and their use as inhibitors of cholesterol synthesis
    Patent number: 5102915
    Abstract: The present invention relates to a group of compounds which are novel squalene derivatives containing the cyclopropyloxy functionality and which act to inhibit the synthesis of cholesterol in mammals and in fungi.
    Type: Grant
    Filed: June 28, 1991
    Date of Patent: April 7, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Michael R. Angelastro, Norton P. Peet, Philippe Bey
  • Novel A-nor-steroid-3-carboxylic acid derivatives
    Patent number: 5100917
    Abstract: The present invention relates to novel A-nor-steroid-3-carboxylic acid derivatives and to their use as inhibitors of mammalian 5.alpha.-reductase.
    Type: Grant
    Filed: September 11, 1990
    Date of Patent: March 31, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Philippe Bey, Thomas R. Blohm
  • Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
    Patent number: 5066828
    Abstract: This invention relates to certain conjugates of folates and antifolates with difluoroglutamic acid which are useful in the treatment of patients suffering from certain neoplastic diseases including leukemia, melanomas, carcinomas, sarcomas and mixed neoplasias.
    Type: Grant
    Filed: April 12, 1990
    Date of Patent: November 19, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Philippe Bey, H. Michael Kolb