Abstract: A method for cleaning a spraying circuit, in particular of paint, and for treating the chemical effluents generated includes a first rinsing of the paint circuit using a predetermined first volume of treated effluent, a second rinsing of the paint circuit using a predetermined second volume of ecosolvent and a third rinsing of the paint circuit using a predetermined third volume of treated effluent, so as to save on the consumption of water from the network by recycling the treated effluent to clean and rinse the paint circuit.

Abstract: Techniques are disclosed for designing a supply chain distribution network. A network design tool may be configured to facilitates strategic decision making for a producer/distributor of a commodity products (e.g., molecular gas mixtures stored in cylinders) by incorporating transportation costs (i.e., operational decisions) into the strategic decision making process. Further, the network design tool may also integrate investment decision costs, which are usually considered ‘tactical decisions’, into the strategic decision process (e.g., which filling tools are assigned to which plant/hub location). The network design tool implements different algorithm approaches allowing a user to obtain optimal, near-optimal, and approximate solutions.

Abstract: A method for cleaning a spraying circuit, in particular of paint, and for treating the chemical effluents generated includes a first rinsing of the paint circuit using a predetermined first volume of treated effluent, a second rinsing of the paint circuit using a predetermined second volume of ecosolvent and a third rinsing of the paint circuit using a predetermined third volume of treated effluent, so as to save on the consumption of water from the network by recycling the treated effluent to clean and rinse the paint circuit.

Abstract: Techniques are disclosed for generating a delivery schedule for distributing commodity products to a group of customers grouped by clusters. For example, a distributor/producer of refined gasses distributed via cylinders may create a proposed delivery schedule limiting the days at which product is delivered to different customers. A delivery planning application may include a clustering module a set of input data to generate a set of clusters representing groups of customers, e.g., using a Greedy Algorithm optimized using a Tabu search. Once the clusters are generated, a planning module may be used to affect trucks (or other delivery vehicles) to clusters. A truck affected to a given cluster by the delivery planning application is then scheduled to deliver cylinders to that cluster. The delivery schedule may provide a reusable two-week plan for servicing a group of customers in a supply chain network.

Abstract: Techniques are disclosed for designing a supply chain distribution network. A network design tool may be configured to facilitates strategic decision making for a producer/distributor of a commodity products (e.g., molecular gas mixtures stored in cylinders) by incorporating transportation costs (i.e., operational decisions) into the strategic decision making process. Further, the network design tool may also integrate investment decision costs, which are usually considered ‘tactical decisions’, into the strategic decision process (e.g., which filling tools are assigned to which plant/hub location). The network design tool implements different algorithm approaches allowing a user to obtain optimal, near-optimal, and approximate solutions.

Abstract: The invention concerns the use of at least an antidiabetic selected among compounds stimulation insulin secretion, glucosidase inhibitors, thiazolidine-diones, insulin, agents enhancing insulin sensitivity, the glucagon-like peptide-1 (GLP-1), PPAR&agr;/&ggr; agonists, meglitinide and aP2 inhibitors for making a medicine with cicatrizing effect.

Abstract: A pharmaceutical composition comprising: (i) metformin, optionally in the form one of its pharmaceutically acceptable salts; (ii) a fibrate selected from fenofibrate and bezafibrate; and optionally one or more pharmaceutically acceptable excipients, is suitable for use in the treatment of non-insulin-dependent diabetes.

Abstract: Substituted six-membered benzo-fused heterocycles of the formula (I) ##STR1## in which: X=0, NH, S.fwdarw.(O).sub.n (n=0 or 2);R.sub.1 is phenyl, phenyl substituted by methoxy, hydroxy, chlorine, fluorine, diethylaminoethoxy, phenoxy, 2-methyl-4-thiazolyl, 2-amino-4-thiazolyl, phenyl, amino, nitro, terbutyl, carboxymethyl, acetamido, dimethyltriazenyl, benzoyl, hexyl, undecyl, trifluoromethyl, carbamoyl; or R.sub.1 is trifluoromethyl, pyridyl-2,pyridyl-4;R.sub.2 is H, methoxy, hydroxy; orR.sub.1 and R.sub.2 are --CH.dbd.CH--CH.dbd.CH--;R.sub.3 and R.sub.4 are methoxy, hydroxy, fluorine or form a fused benzene ring;CR.sub.5 R.sub.6 R.sub.7 is carboxymethyl, --CH.sub.2 --PO.sub.3 H,--CH.sub.2 --PO(oET).sub.2, 4-methylpiperazinyl, aminomethyl,3-4-5-trimethoxyphenylaminomethyl, acetyl, bromoacetyl, hydroxyethyl, acetoxyethyl, mercaptomethyl, acetylthiomethyl, methoxy-carbopnylthiomethyl, --CH--CONH.sub.2, ##STR2## substituted thiazolyl, subsituted furanone, imidazo(1,2-a)pyridinyl, indolizinyl, or R.sub.4 and R.

Abstract: The invention concerns [oxo-4-4H-[1]-benzopyran-8-yl]-alcanoic acids and their derivatives, their manufacture, represented by the formula. ##STR1## where AR is hydrogen, a phenyl radical which may or may not be substituted thenyl, furyl, naphthyl, a lower alkyl, cycloalkyl, aralkyl radical; B is a linear or branched lower alkyl radical, either saturated or ethylinically unsaturated; R.sub.1 is hydrogen or a phenyl radical; X is hydrogen or a lower alkyl or alkoxy radical and n=1, as well as salts, esters, aminoesters and amides.Compounds and their derivatives may be used as medicines, in particular in the control of tumors.

Abstract: The invention concerns: (oxo-4-4H-(1)-benzopyran-8-yl) alkanoic acids and their derivatives, their manufacture, represented by the formula: ##STR1## where Ar is hydrogen, a phenyl radical which may or may not be substituted, thenyl, furyl, naphthyl, a lower alkyl, cycloalkyl, aralkyl radical; B is a linear or branched lower alkyl radical, either saturated or ethylinically unsaturated; R.sub.1 is hydrogen or a phenyl radical; X is hydrogen or a lower alkyl or alkoxy radical and n=1, as well as salts, esters, aminoesters and amides.Compounds and their derivatives may be used as medicines, in particular in the control of tumors.

Abstract: Novel 3-substituted-4-aminoalkoxy-5,6-condensed ring-2-pyranones are disclosed as having utility as pharmacologically active compounds, in particular vasodilatory, hypotensive, anti-ischemic and anti-tussive activity. The compounds may be 3-phenyl-4-morpholinoalkoxy-coumarins. Administration may be by the oral or parenteral route. Intermediates useful in the production of these compounds are also disclosed.

Abstract: Substituted hexahydro benzopyrano [3,2-c] pyridines, useful as antidepressants, have the formula ##STR1## where R is hydrogen or a saturated or unsaturated, linear or branched, lower alkyl, or an aralkyl, acyl, dialkylaminoalkyl, carbonylalkyl, alkoxycarbonyl, haloalkoxycarbonyl or aryl radical; R.sub.1 is hydrogen, halogen, or lower alkoxy; R.sub.2 is hydrogen or halogen; R.sub.3 is hydrogen, halogen, lower alkyl, alkoxy nitro or amino, or forms naphthalene with R.sub.4 and the benzene ring; R.sub.4 is hydrogen, a halogen, or forms naphthalene with R.sub.3 and the benzene ring; R.sub.5 is hydrogen, lower alkyl, or aralkyl.

Abstract: Propionic acids and their functional derivatives having anti-inflammatory and analgesic properties correspond to the formula ##STR1## in which X is selected from phenyl, halophenyl, polyhalophenyl, lower alkylphenyl, trihalomethylphenyl, aryloxyphenyl, furyl and thienyl and R is selected from hydrogen, lower alkyl, lower omega-hydroxyalkyl, morpholinoethyl and lower dialkylaminoalkyl.

Abstract: Propionic acids and their functional derivatives having anti-inflammatory and analgesic properties correspond to the formula ##STR1## in which X is selected from phenyl, halophenyl, polyhalophenyl, lower alkylphenyl, trihalomethylphenyl, aryloxyphenyl, furyl and thienyl and R is selected from hydrogen, lower alkyl, lower omega-hydroxyalkyl, morpholinoethyl and lower dialkylaminoalkyl.

Abstract: The compound .alpha.-[6-(2-phenyl)-chromonyl]-acetic acid has choleretic and anti-inflammatory activity and is of use in the treatment of hepatic conditions.