Patents by Inventor Philippe Bulet

Philippe Bulet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7723468
    Abstract: The invention refers to small peptides with low hemolytic activity, presenting similar antiparasitic, antifungal and antibacterial activities. More specifically, it refers to a peptide called gomesin, with 18 amino acid residues, configured as a hairpin structure consisting of two anti-parallel beta-folded sheets joined by a beta turn, containing four invariable residues of cysteine forming two disulphide bridges, configurable as a cyclic chain with open or closed ends.
    Type: Grant
    Filed: May 10, 2006
    Date of Patent: May 25, 2010
    Assignee: De Sao Paulo Universida de
    Inventors: Sirlei Daffre, Pedro Ismael Da Silva, Jr., Philippe Bulet
  • Patent number: 7462360
    Abstract: The invention belongs to the field of biologically active peptides specifically stimulating antiviral, antimicrobial and antitumor activity of the human and animal immune system.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: December 9, 2008
    Assignee: Entopharm Co., Ltd.
    Inventors: Soo In Kim, Sergey Ivanovich Chernysh, German Petrovich Bekker, Natalia Borisovna Makhaldiani, Jules Hoffman, Philippe Bulet
  • Patent number: 7384911
    Abstract: An isolated peptide including an amino acid sequence of formula (II): wherein Xaa is Ser-Phe-Gly-Leu, Xab is Arg-Leu-Arg-Arg-Gly-Phe, Xac is Ala-Xac2-Gly-Arg, Xad is Arg-Phe-Pro-Ser-Ile-Pro-Ile-Gly-Arg, Xae is Ser-Arg-Phe-Val-Gln, and Xaf is Arg-Arg-Val-Trp, Xac2 is histidine or arginine, Ca1, Ca2, Ca3, Ca4, Ca5 and Ca6 are sulfur containing amino acids, wherein each of Ca1-Ca5, Ca2-Ca4 and Ca3-Ca6 are linked together by a sulfur bridge, and wherein the amino acid sequence has antimicrobial activity.
    Type: Grant
    Filed: December 30, 2004
    Date of Patent: June 10, 2008
    Assignee: Centre National de la Recherche Scientifique - CNRS
    Inventors: Philippe Bulet, CĂ©cile Thouzeau, Yvon LeMaho
  • Publication number: 20060276380
    Abstract: The invention refers to small peptides with low hemolytic activity, presenting similar antiparasitic, antifungal and antibacterial activities. More specifically, it refers to a peptide called gomesin, with 18 amino acid residues, configured as a hairpin structure consisting of two anti-parallel beta-folded sheets joined by a beta turn, containing four invariable residues of cysteine forming two disulphide bridges, configurable as a cyclic chain with open or closed ends.
    Type: Application
    Filed: May 10, 2006
    Publication date: December 7, 2006
    Inventors: Sirlei Daffre, Pedro De Silva Jr, Philippe Bulet
  • Publication number: 20050245437
    Abstract: A peptide comprising one or more intramolecular bonds corresponding to formula (I): Xaa-Ca1-Xab-Ca2-Xac-Ca3-Xad-Ca4-Xae-Ca5-Ca6-Xaf ??(I), having antimicrobial properties and compositions containing them, notably for the preservation of foodstuffs.
    Type: Application
    Filed: December 30, 2004
    Publication date: November 3, 2005
    Applicant: Centre National de la Recherche Scientifique - CNRS, a corporation of France
    Inventors: Philippe Bulet, Cecile Thouzeau, Yvon LeMaho
  • Patent number: 6916782
    Abstract: The invention concerns heliomicine, A DNA sequence coding for heliomicine, a vector containing it for transfroming a host organism and the transformation method. The invention concerns heliomicine as a medicine in particular for treating fungal infections. More particularly, it concerns the transformation of plant cells and plants, the heliomicine produced by the transformed plants ensuring their resistance to diseases, in particular diseases of fungal origin.
    Type: Grant
    Filed: April 12, 1999
    Date of Patent: July 12, 2005
    Assignee: Aventis Cropscience S.A.
    Inventors: Mireille Lamberty, Philippe Bulet, Gary Brookhart, Jules Hoffman
  • Publication number: 20040138137
    Abstract: The invention belongs to the field of biologically active peptides specifically stimulating antiviral, antimicrobial and antitumor activity of the human and animal immune system.
    Type: Application
    Filed: December 23, 2003
    Publication date: July 15, 2004
    Applicant: Entopharm Co., Ltd.
    Inventors: Soo In Kim, Sergey Ivanovich Chernysh, German Petrovich Bekker, Natalia Borisovna Makhaldiani, Jules Hoffman, Philippe Bulet
  • Publication number: 20040087771
    Abstract: The invention concerns novel antimicrobial peptides of the family of defensins, in particular antifungal, called termicines, polynucleotides encoding said peptides, vectors containing them for transforming a host organism and the method for transforming said organism. The invention also concerns transformed organisms, in particular yeast producing termicine, or plant cells and plants, the termicines produced by the transformed plats providing them with resistence to fungus-mediated diseases. The invention further concerns the use of termicines as medicine and pharmaceutical compositions containing them.
    Type: Application
    Filed: April 28, 2003
    Publication date: May 6, 2004
    Inventors: Mireille Lamberty, Philippe Bulet, Marie-Pascale Latorse, Jules Hoffmann
  • Patent number: 6692747
    Abstract: The invention belongs to the field of biologically active peptides specifically stimulating antiviral, antimicrobial and antitumor activity of the human and animal immune system.
    Type: Grant
    Filed: December 27, 2000
    Date of Patent: February 17, 2004
    Assignee: Entopharm Co., Ltd.
    Inventors: Soo In Kim, Sergey Ivanovich Chernysh, German Petrovich Bekker, Natalia Borisovna Makhaldiani, Jules Hoffman, Philippe Bulet
  • Patent number: 6642203
    Abstract: The invention concerns antimicrobial peptides obtained from penaeid prawns having the following characteristics: a molecular mass of about 5 to 7 kDa; a pHi not less than 9; an N-terminal portion comprising a region (A) of about 15 to 25 amino acids rich in proline; and a C-terminal portion comprising a region (B) of about 20 to 30 amino acids and containing 6 cysteine residues forming three intramolecular disulfide bonds. The invention also concerns the nucleic acid sequences coding for said peptides and enabling their production by genetic engineering.
    Type: Grant
    Filed: April 12, 2000
    Date of Patent: November 4, 2003
    Assignees: Institut Francais de Recherche pour l'Exploitation de la Mer, Centre National de la Recherche Scientifique
    Inventors: Delphine Destoumieux, Evelyne Bachere, Philippe Bulet
  • Publication number: 20020151679
    Abstract: The invention belongs to the field of biologically active peptides specifically stimulating antiviral, antimicrobial and antitumor activity of the human and animal immune system.
    Type: Application
    Filed: December 27, 2000
    Publication date: October 17, 2002
    Inventors: Soo In Kim, Sergey Ivanovich Chernysh, German Petrovich Bekker, Natalia Borisovna Makhaldiani, Jules Hoffman, Philippe Bulet
  • Patent number: 6331522
    Abstract: The present invention provides a peptide with antibacterial and antifungal properties, and compositions containing the peptide. Methods of making and using the antibacterial and antifungal peptide are also provided.
    Type: Grant
    Filed: March 13, 2000
    Date of Patent: December 18, 2001
    Assignee: Aventis CropScience SA
    Inventors: Philippe Bulet, Charles Hetru, Jules Hoffmann, Laurence Sabatier
  • Patent number: 6127336
    Abstract: The present invention provides a peptide with antibacterial and antifungal properties, and compositions containing the peptide. Methods of making and using the antibacterial and antifungal peptide are also provided.
    Type: Grant
    Filed: November 16, 1998
    Date of Patent: October 3, 2000
    Assignee: Rhone-Poulenc Agro
    Inventors: Philippe Bulet, Charles Hetru, Jules Hoffmann, Laurence Sabatier