Abstract: A needle safety device includes a sleeve having proximal and distal portions separated by a radially-inwardly projecting ledge. A ring in the proximal portion is movable between a first position spaced from the ledge, and a second position adjacent to or abutting the ledge. A shield with at least one radially deformable tab receives the syringe and is movable in the sleeve between an initial position with the tab adjacent to or abutting the ledge, an injection position with the tab spaced from the ledge, and a protection position with the tab located distally from the ledge. The tab, during movement between initial and injection positions, deforms inwardly and traverses the inner surface of the ring, and during movement between injection and protection positions, translates with the ring from the first to the second position, and subsequently deforms inwardly and traverses the inner surface of the ring and the ledge.

Abstract: A needle safety device includes a sleeve having proximal and distal portions separated by a radially-inwardly projecting ledge. A ring in the proximal portion is movable between a first position spaced from the ledge, and a second position adjacent to or abutting the ledge. A shield with at least one radially deformable tab receives the syringe and is movable in the sleeve between an initial position with the tab adjacent to or abutting the ledge, an injection position with the tab spaced from the ledge, and a protection position with the tab located distally from the ledge. The tab, during movement between initial and injection positions, deforms inwardly and traverses the inner surface of the ring, and during movement between injection and protection positions, translates with the ring from the first to the second position, and subsequently deforms inwardly and traverses the inner surface of the ring and the ledge.

Abstract: A preventive and therapeutic drug for a neurodegenerative disease containing, as an active ingredient, a cyclohexenone long-chain alcohol compound represented by formula (1) wherein each of R1, R2, and R3 represents a hydrogen atom or a methyl group; and X represents a C10–C28 alkylene group or alkenylene group. Since the compound of the present invention exhibits excellent neurite-extension ability and an inhibition effect on disorders caused by mutation in an SOD gene, it is useful as the active ingredient of a preventive and therapeutic drug for neurodegenerative diseases, inter alia, amyotrophic lateral sclerosis, and as the active ingredient of an inhibitory drug for disorders caused by mutation in an SOD gene.